Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102506 - 102506
Published: Jan. 1, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215579 - 215579
Published: Nov. 28, 2023
Language: Английский
Citations
58
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608
Published: Jan. 1, 2024
Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy
Language: Английский
Citations
37
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 14, 2024
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.
Language: Английский
Citations
17
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2529 - 2552
Published: March 1, 2024
Abstract: The blood-brain barrier (BBB) and blood-tumor (BTB) pose substantial challenges to efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor prognosis. Nanoparticle-based combinational strategies have emerged as promising modalities overcome these barriers enhance penetration into the parenchyma. This review discusses various nanoparticle-based combinatorial approaches that combine nanoparticles cell-based delivery, viral focused ultrasound, magnetic field, intranasal permeability across BBB BTB. Cell-based involves using engineered cells carriers nanoparticles, taking advantage of their intrinsic migratory homing capabilities facilitate transport therapeutic payloads Viral uses vectors deliver genes or specific within GBM microenvironment. Focused coupled microbubbles can temporarily disrupt increase permeability. Magnetic field-guided exploits targeted under an external field. Intranasal offers minimally invasive avenue bypass agents directly via olfactory trigeminal pathways. By combining strategies, synergistic effects efficiency, improve efficacy, reduce off-target effects. Future research should focus on optimizing nanoparticle design, exploring new combination advancing preclinical clinical investigations promote translation therapies GBM. Keywords: glioblastoma, barrier, nanoparticle, strategy, ultrasound-wave,
Language: Английский
Citations
16
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)
Published: Jan. 16, 2025
Language: Английский
Citations
2
Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101005 - 101005
Published: Aug. 21, 2023
Multidrug resistance in pancreatic cancer poses a significant challenge clinical treatment. Bufalin (BA), compound found secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its application. Hence, present study aimed to develop cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) assess potential counter chemoresistance cancer.The toxicity CBAP was evaluated by electrocardiogram, body weight, distress score, nesting behavior mice. In addition, anticarcinoma activity underlying mechanism were investigated both vitro vivo.CBAP significantly mitigated BA-mediated acute enhanced sensitivity several drugs, such as gemcitabine, 5-fluorouracil, FOLFIRINOX. Mechanistically, directly bound nucleotide-binding oligomerization domain containing protein 2 (NOD2) inhibited expression nuclear factor kappa-light-chain-enhancer activated B cells. This inhibits ATP-binding cassette transporters, which are responsible for cells.Our findings indicate that NOD2. Combining with standard-of-care chemotherapeutics represents safe efficient strategy treatment cancer.
Language: Английский
Citations
30
Bioengineering & Translational Medicine, Journal Year: 2023, Volume and Issue: 8(5)
Published: June 7, 2023
Malignant tumors are one of the leading causes death which impose an increasingly heavy burden on all countries. Therefore, establishment research models that closely resemble original tumor characteristics is crucial to further understanding mechanisms malignant development, developing safer and more effective drugs, formulating personalized treatment plans. Recently, organoids have been widely used in owing their advantages including preserving structure, heterogeneity, cellular functions tumor, together with ease manipulation. This review describes history synergistic combination three-dimensional (3D) culture approaches for emerging technologies, tissue-engineered cell scaffolds, microfluidic devices, 3D bioprinting, rotating wall vessels, clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR-Cas9). Additionally, progress applications basic clinical organoid summarized. includes studies mechanism drug development screening, precision medicine, immunotherapy, simulation microenvironment. Finally, existing shortcomings possible future directions discussed.
Language: Английский
Citations
28
Small, Journal Year: 2023, Volume and Issue: 20(23)
Published: Dec. 27, 2023
Abstract Nanocatalytic‐based wound therapeutics present a promising strategy for generating reactive oxygen species (ROS) to antipathogen promote healing. However, the full clinical potential of these nanocatalysts is limited by their low reactivity, targeting ability, and poor biodegradability in microenvironment. Herein, bio‐organic nanozyme developed encapsulating FeZn‐based bimetallic organic framework (MOF) (MIL‐88B‐Fe/Zn) platelet membranes (PM@MIL‐88B‐Fe/Zn) antimicrobial activity during The introduction Zn MIL‐88B‐Fe/Zn modulates electronic structure Fe thus accelerating catalytic kinetics its peroxidase‐like catalytically generate powerful ROS. membrane coating MOF innovatively enhanced interaction between nanoparticles biological environment, further developing bacterial‐targeted therapy with excellent antibacterial against both gram‐positive gram‐negative bacteria. Furthermore, this markedly suppressed levels inflammatory cytokines promoted angiogenesis vivo effectively treat skin surface wounds accelerate PM@MIL‐88B‐Fe/Zn exhibited superior biodegradability, favourable metabolism non‐toxic accumulation, eliminating concerns regarding side effects from long‐term exposure. high features, nanoenzymes study provide useful insights into design synthesis nanocatalysts/nanozymes practical biomedical applications.
Language: Английский
Citations
26
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 707 - 707
Published: May 30, 2024
Mesenchymal stem cells (MSCs) have emerged as a promising approach for drug delivery strategies because of their unique properties. These include cell membrane-coated nanoparticles, cell-derived extracellular vesicles, immunomodulatory effects, cell-laden scaffolds, and scaffold-free sheets. MSCs offer advantages such low immunogenicity, homing ability, tumor tropism, making them ideal targeted systems. Stem vesicles gained attention immune properties tumor-homing abilities, presenting potential solution challenges. The relationship between MSC-based the self-renewal differentiation capabilities lies in engineered to serve effective carriers therapeutic agents while maintaining intrinsic exhibit potent immunosuppressive functions strategies. EVs immunogenicity strong tissue repair regeneration. Scaffold-free sheets represent cutting-edge regenerative medicine, offering versatile platform engineering regeneration across different medical specialties. shown great clinical applications medicine ability differentiate into various types, secrete bioactive factors, modulate responses. Researchers are exploring these innovative approaches enhance efficiency effectiveness treating diseases.
Language: Английский
Citations
13
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6857 - 6893
Published: July 1, 2024
Periodontitis is a disease of inflammation that affects the tissues supporting periodontium. It triggered by an immunological reaction gums to plaque, which leads destruction periodontal attachment structures. one most commonly recognized dental disorders in world and major factor loss adult teeth. Scaling root planing remain crucial for managing patients with persistent periodontitis. Nevertheless, exclusive reliance on mechanical interventions like surgery, extractions, planning insufficient halt progression In response problem bacterial resistance, some researchers are committed finding alternative therapies antibiotics. addition, scholars focus new materials provide powerful microenvironment tissue regeneration promote osteogenic repair. Nanoparticles possess distinct therapeutic qualities, including exceptional antibacterial, anti-inflammatory, antioxidant properties, immunomodulatory capacities, promotion bone ability, made them can be used treatment However, there many problems limit clinical translation nanoparticles, such as toxic accumulation cells, poor correlation between vitro vivo, animal-to-human transmissibility. this paper, we review present researches nanoparticles periodontitis from perspective three main categories: inorganic organic nanocomposites (including nanofibers, hydrogels, membranes). The aim comprehensive recent update nanoparticles-based conclusion section summarizes opportunities challenges design
Language: Английский
Citations
10