ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 5823 - 5840
Published: Aug. 15, 2024
Hydrogel
microfibers
are
hydrogel
materials
engineered
into
fiber
structures.
Techniques
such
as
wet
spinning,
microfluidic
and
3D
bioprinting
often
used
to
prepare
due
their
ability
precisely
control
the
size,
morphology,
structure
of
microfibers.
Microfibers
with
different
structural
morphologies
have
functions;
they
provide
a
flow-through
culture
environment
for
cells
improve
viability,
can
also
be
induce
differentiation
skeletal
muscle
cardiac
eventually
form
functional
organs
in
vitro
through
special
morphologies.
This
Review
introduces
recent
advances
microfluidics,
bioprinting,
spinning
preparation
microfibers,
focusing
on
fabrication
methods.
The
applications
tissue
engineering
highlighted
by
summarizing
contributions
biomimetic
blood
vessels,
vascularized
tissues,
bone,
heart,
pancreas,
kidney,
liver,
fat.
Furthermore,
fibers
repair
drug
screening
discussed.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 111 - 128
Published: Jan. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 24, 2023
Abstract
Functional
hydrogels
show
potential
application
in
repairing
spinal
cord
injury
(SCI)
due
to
their
unique
chemical,
physical,
and
biological
properties
functions.
In
this
comprehensive
review,
we
present
recent
advance
the
material
design,
functional
regulation,
SCI
repair
applications
of
bioactive
hydrogels.
Different
from
previously
released
reviews
on
three-dimensional
scaffolds
for
repair,
work
focuses
strategies
design
biologically
regulation
hydrogels,
specifically
aiming
how
these
significant
efforts
can
promoting
performance
SCI.
We
demonstrate
various
methods
techniques
fabrication
with
components
such
as
DNA,
proteins,
peptides,
biomass
polysaccharides,
biopolymers
obtain
including
cell
biocompatibility,
self-healing,
anti-bacterial
activity,
injectability,
bio-adhesion,
bio-degradation,
other
multi-functions
The
drugs/growth
factors,
polymers,
nanoparticles,
one-dimensional
materials,
two-dimensional
materials
highly
effective
treating
are
introduced
discussed
detail.
This
shows
new
viewpoints
ideas
synthesis
state-of-the-art
knowledges
science
nanotechnology,
will
bridge
connection
biomedicine,
further
inspire
clinical
biomedical
fields.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 9, 2024
Extensive
research
on
zeolitic
imidazolate
framework
(ZIF-8)
and
its
derivatives
has
highlighted
their
unique
properties
in
nanomedicine.
ZIF-8
exhibits
advantages
such
as
pH-responsive
dissolution,
easy
surface
functionalization,
efficient
drug
loading,
making
it
an
ideal
nanosystem
for
intelligent
delivery
phototherapy.
These
characteristics
have
sparked
significant
interest
potential
applications
tissue
regeneration,
particularly
bone,
skin,
nerve
regeneration.
This
review
provides
a
comprehensive
assessment
of
ZIF-8’s
feasibility
engineering,
encompassing
material
synthesis,
performance
testing,
the
development
multifunctional
nanosystems.
Furthermore,
latest
advancements
field,
well
limitations
future
prospects,
are
discussed.
Overall,
this
emphasizes
developments
engineering
highlights
nanoplatforms
effective
complex
repair.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(3), P. 032003 - 032003
Published: April 3, 2024
Abstract
Regenerative
healing
of
spinal
cord
injury
(SCI)
poses
an
ongoing
medical
challenge
by
causing
persistent
neurological
impairment
and
a
significant
socioeconomic
burden.
The
complexity
tissue
presents
hurdles
to
successful
regeneration
following
injury,
due
the
difficulty
forming
biomimetic
structure
that
faithfully
replicates
native
using
conventional
engineering
scaffolds.
3D
bioprinting
is
rapidly
evolving
technology
with
unmatched
potential
create
biological
tissues
complicated
hierarchical
composition.
With
addition
additives
such
as
cells
biomolecules,
can
fabricate
preclinical
implants,
or
organ-like
constructs,
in
vitro
models
through
precise
control
over
deposition
biomaterials
other
building
blocks.
This
review
highlights
characteristics
advantages
for
scaffold
fabrication
enable
SCI
repair,
including
bottom–up
manufacturing,
mechanical
customization,
spatial
heterogeneity.
also
critically
discusses
impact
various
parameters
on
efficacy
repair
bioprinted
scaffolds,
choice
printing
method,
shape,
biomaterials,
supplements
growth
factors.
High-quality
studies
are
required
accelerate
translation
into
clinical
practice
repair.
Meanwhile,
technological
advances
will
continue
improve
regenerative
capability
incorporation
nanoscale
particles
development
4D
printing.
