Cells,
Journal Year:
2023,
Volume and Issue:
12(19), P. 2350 - 2350
Published: Sept. 25, 2023
Silk
has
a
long
history
as
an
exclusive
textile,
but
also
suture
thread
in
medicine;
nowadays,
diverse
cell
carriers
are
manufactured
from
silk.
Its
advantages
manifold,
including
high
biocompatibility,
biomechanical
strength
and
processability
(approved
for
nearly
all
manufacturing
techniques).
Silk’s
limitations,
such
scarcity
batch
to
variations,
overcome
by
gene
technology,
which
allows
the
upscaled
production
of
recombinant
“designed”
silk
proteins.
For
processing
thin
fibroin
filaments,
sericin
component
is
generally
removed
(degumming).
In
contrast
many
synthetic
biomaterials,
superior
adherence
growth.
addition,
grafts
demonstrate
mechanical
performance
long-term
stability,
making
them
attractive
anterior
cruciate
ligament
(ACL)
tissue
engineering.
Looking
at
these
promising
properties,
this
review
focusses
on
responses
types
variants,
well
their
relevant
ACL
Meanwhile,
attracted
increasing
interest
been
proposed
bioactive
biomaterial
with
antimicrobial
properties.
But
so
far,
was
exclusively
used
experimental
engineering
approaches,
spider
seems
not
have
applied.
To
improve
bone
integration
grafts,
scaffolds
osteogenic
functionalization,
silk-based
tunnel
fillers
interference
screws
developed.
Nevertheless,
signaling
pathways
stimulated
components
remain
barely
elucidated,
need
be
considered
during
development
optimized
Micromachines,
Journal Year:
2023,
Volume and Issue:
14(9), P. 1786 - 1786
Published: Sept. 18, 2023
Exploring
bio-inspired
nanomaterials
(BINMs)
and
incorporating
them
into
micro/nanodevices
represent
a
significant
development
in
biomedical
applications.
Nanomaterials,
engineered
to
imitate
biological
structures
processes,
exhibit
distinctive
attributes
such
as
exceptional
biocompatibility,
multifunctionality,
unparalleled
versatility.
The
utilization
of
BINMs
demonstrates
potential
diverse
domains
micro/nanodevices,
encompassing
biosensors,
targeted
drug
delivery
systems,
advanced
tissue
engineering
constructs.
This
article
thoroughly
examines
the
various
BINMs,
including
those
originating
from
proteins,
DNA,
biomimetic
polymers.
Significant
attention
is
directed
toward
these
entities
subsequent
ramifications
that
arise.
review
explores
biomimicry’s
structure–function
correlations.
Synthesis
mosaics
include
bioprocesses,
biomolecules,
natural
structures.
These
nanomaterials’
interfaces
use
functionalization
geometric
adaptations,
transforming
delivery,
nanobiosensing,
organ-on-chip
cancer-on-chip
models,
wound
healing
dressing
mats,
antimicrobial
surfaces.
It
provides
an
in-depth
analysis
existing
challenges
proposes
prospective
strategies
improve
efficiency,
performance,
reliability
devices.
Furthermore,
this
study
offers
forward-thinking
viewpoint
highlighting
avenues
for
future
exploration
advancement.
objective
effectively
utilize
maximize
application
progression
thereby
propelling
rapidly
developing
field
its
promising
future.
Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 133 - 133
Published: March 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
35(5), P. 717 - 755
Published: Jan. 12, 2024
Corneal
diseases
are
a
major
cause
of
vision
loss
worldwide.
Traditional
methods
like
corneal
transplants
from
donors
effective
but
face
challenges
limited
donor
availability
and
the
risk
graft
rejection.
Therefore,
new
treatment
essential.
This
review
examines
growing
field
bioprinting
biofabrication
in
tissue
engineering.
We
begin
by
discussing
various
such
as
stereolithography,
inkjet,
extrusion
printing,
highlighting
their
strengths
weaknesses
for
eye-related
uses.
also
explore
how
biological
tissues
made
suitable
through
process
called
decellularization,
which
can
be
achieved
using
chemical,
physical,
or
methods.
The
then
looks
at
natural
materials,
known
bioinks,
used
bioprinting.
focus
on
materials
gelatin,
collagen,
fibrin,
chitin,
chitosan,
silk
fibroin,
alginate,
examining
mechanical
properties.
importance
hydrogel
scaffolds,
particularly
those
based
collagen
other
is
discussed
context
repairing
tissue.
Another
key
area
we
cover
use
stem
cells
regeneration.
pay
special
attention
to
limbal
epithelial
mesenchymal
stromal
cells,
roles
this
process.
concludes
with
an
overview
latest
advancements
bioprinting,
early
techniques
advanced
delivering
bioengineered
materials.
In
summary,
presents
current
state
future
potential
creating
functional
tissues,
developments
ongoing
view
towards
restoring
vision.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Abstract
Regenerative
biomedicine
has
emerged
as
a
forefront
area
in
medical
research,
heralding
new
era
of
therapeutic
strategies.
This
review
delineates
the
integration
2D
materials
(2DMs)
within
biomedical
engineering,
leveraging
their
superior
physicochemical
attributes
for
enhance
outcomes.
The
synergistic
interaction
between
biomacromolecules
and
2DMs
is
explored,
demonstrating
potential
to
mitigate
limitations
inherent
each
while
simultaneously
augmenting
beneficial
properties.
In
particular,
incorporating
into
hydrogels
highlights
capability
mechanical
strength
hydrogels,
providing
biomimetic
scaffold
tissue
engineering
regeneration
cancer
diagnosis
therapy.
An
overview
synthetic
methodologies
are
provided
2DMs,
elucidating
dynamics
with
biomacromolecules.
primarily
concentrates
on
applications
biomacromolecule‐reinforced
2DM
across
various
fields,
including
bone
wound
healing,
neural
cardiac
well
delivery
drugs
genes,
therapy,
biosensing
technologies.
Finally,
discusses
existing
challenges
future
outlook
developing
using
underlining
transformative
regenerative
medicine.
Materials,
Journal Year:
2024,
Volume and Issue:
17(19), P. 4792 - 4792
Published: Sept. 29, 2024
Hydrogels,
known
for
their
unique
ability
to
retain
large
amounts
of
water,
have
emerged
as
pivotal
materials
in
both
tissue
engineering
and
biosensing
applications.
This
review
provides
an
updated
comprehensive
examination
cutting-edge
hydrogel
technologies
multifaceted
roles
these
fields.
Initially,
the
chemical
composition
intrinsic
properties
natural
synthetic
hydrogels
are
discussed,
highlighting
biocompatibility
biodegradability.
The
manuscript
then
probes
into
innovative
scaffold
designs
fabrication
techniques
such
3D
printing,
electrospinning,
self-assembly
methods,
emphasizing
applications
regenerating
bone,
cartilage,
skin,
neural
tissues.
In
realm
biosensing,
hydrogels’
responsive
nature
is
explored
through
integration
optical,
electrochemical,
piezoelectric
sensors.
These
sensors
instrumental
medical
diagnostics
glucose
monitoring,
pathogen
detection,
biomarker
identification,
well
environmental
industrial
like
pollution
food
quality
monitoring.
Furthermore,
explores
cross-disciplinary
innovations,
including
use
wearable
devices,
hybrid
systems,
potential
personalized
medicine.
By
addressing
current
challenges
future
directions,
this
aims
underscore
transformative
impact
advancing
healthcare
practices,
thereby
providing
a
vital
resource
researchers
practitioners
field.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(3), P. 035025 - 035025
Published: May 22, 2024
Abstract
Silk
fibroin
(SF)
is
a
natural
protein
extracted
from
Bombyx
mori
silkworm
thread.
From
its
common
use
in
the
textile
industry,
it
emerged
as
biomaterial
with
promising
biochemical
and
mechanical
properties
for
applications
field
of
tissue
engineering
regenerative
medicine.
In
this
study,
we
evaluate
first
time
effects
SF
on
cardiac
bioink
formulations
containing
spheroids
(CSs).
First,
if
addition
plays
role
structural
elastic
hydrogels
alginate
(Alg)
gelatin
(Gel).
Then,
test
printability
durability
bioprinted
SF-containing
hydrogels.
Finally,
whether
controls
cell
viability
function
CSs
Alg–Gel
Our
findings
show
that
1%
(w/v)
to
makes
them
more
without
affecting
viability.
However,
fractional
shortening
(FS%)
SF–Alg–Gel
increases
their
contraction
frequency,
suggesting
an
improvement
contractile
3D
cultures.
Altogether,
our
support
pathway
bioengineer
bioinks
applications,
ability
control
cellular
features
bioinks.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(13), P. 1878 - 1878
Published: July 1, 2024
Heart
problems
are
quite
prevalent
worldwide.
Cardiomyocytes
and
stem
cells
two
examples
of
the
supporting
matrix
that
used
in
integrated
process
cardiac
tissue
regeneration.
The
objective
is
to
create
innovative
materials
can
effectively
replace
or
repair
damaged
muscle.
One
most
effective
appealing
3D/4D
scaffolds
for
creating
an
appropriate
milieu
growth
healing
hydrogel.
In
order
successfully
regenerate
heart
tissue,
bioactive
biocompatible
hydrogels
required
preserve
infarcted
region
bid
support
restoration
myocardial
wall
stress,
cell
survival
function.
engineering
uses
a
variety
hydrogels,
such
as
natural
synthetic
polymeric
hydrogels.
This
article
provides
quick
overview
various
hydrogel
types
employed
engineering.
Their
benefits
drawbacks
discussed.
Hydrogel-based
techniques
regeneration
also
addressed,
along
with
their
clinical
application
future
