Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(32), P. 6835 - 6840
Published: Aug. 7, 2024
There
are
only
a
few
examples
being
reported
for
the
simultaneous
control
of
central
chirality
and
axial
because
it
is
more
challenging.
Herein,
we
report
an
iridium-catalyzed
asymmetric
hydroarylation
unactivated
alkenes
with
heterobiaryls
to
simultaneously
construct
chirality.
The
reaction
showed
broad
substrate
scope
delivered
products
satisfactory
results.
results
experiments
demonstrated
that
FerroLANE
ligand
promotes
proceed
along
specific
modified
Chalk-Harrod
mechanism.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(3)
Published: Nov. 2, 2023
With
the
rapid
development
of
asymmetric
catalysis,
demand
for
enantioselective
synthesis
complex
and
diverse
molecules
with
different
chiral
elements
is
increasing.
Owing
to
unique
features
atropisomerism,
catalytic
atropisomers
has
attracted
a
considerable
interest
from
chemical
science
community.
In
particular,
introducing
additional
elements,
such
as
carbon
centered
chirality,
heteroatomic
planar
helical
into
provides
an
opportunity
incorporate
new
properties
axially
compounds,
thus
expanding
potential
applications
atropisomers.
Thus,
it
important
perform
transformations
synthesize
bearing
multiple
elements.
spite
challenges
in
transformations,
recent
years,
chemists
have
devised
powerful
strategies
under
organocatalysis
or
metal
synthesizing
wide
range
enantioenriched
Therefore,
become
emerging
field.
This
review
summarizes
progress
this
field
indicates
challenges,
thereby
promoting
horizon.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 25, 2024
Abstract
The
assembly
of
chiral
molecules
with
multiple
stereogenic
elements
is
challenging,
and,
despite
indisputable
advances,
largely
limited
to
toxic,
cost-intensive
and
precious
metal
catalysts.
In
sharp
contrast,
we
herein
disclose
a
versatile
C–H
alkylation
using
non-toxic,
low-cost
iron
catalyst
for
the
synthesis
substituted
indoles
two
elements.
key
achieving
excellent
diastereo-
enantioselectivity
was
substitution
on
N
-heterocyclic
carbene
ligand
providing
steric
hindrance
extra
represented
by
noncovalent
interaction
concomitant
generation
C–N
axial
chirality
C
-stereogenic
center.
Experimental
computational
mechanistic
studies
have
unraveled
origin
catalytic
efficacy
stereoselectivity.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 3867 - 3871
Published: May 1, 2024
Herein,
a
highly
regio-,
enantio-,
and
diastereoselective
nickel-catalyzed
desymmetric
hydrocyanation
of
biaryl
dienes
for
the
simultaneous
construction
axial
central
chiralities
is
presented,
which
offers
convenient
approach
to
variety
tirenes
containing
union
an
axially
chiral
centrally
α-chiral
nitrile
under
mild
conditions
using
commercially
available
catalyst.
The
synthetic
utility
highlighted
by
development
novel
phosphine
ligand
biphenyl-based
diene
their
potential
applications
in
field
asymmetric
catalytic
reactions.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 55 - 121
Published: Jan. 9, 2025
Axial
chirality
is
present
in
a
variety
of
naturally
occurring
compounds,
and
becoming
increasingly
relevant
also
medicine.
Many
axially
chiral
compounds
are
important
as
catalysts
asymmetric
catalysis
or
have
chiroptical
properties.
This
review
overviews
recent
progress
the
synthesis
via
organocatalysis.
Atroposelective
organocatalytic
reactions
discussed
according
to
dominant
catalyst
activation
mode.
For
covalent
organocatalysis,
typical
enamine
iminium
modes
presented,
followed
by
N
-heterocyclic
carbene-catalyzed
reactions.
The
bulk
devoted
non-covalent
activation,
where
Brønsted
acids
feature
most
prolific
catalytic
structure.
last
part
article
discusses
hydrogen-bond-donating
other
motifs
such
phase-transfer
catalysts.
