International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 412 - 412
Published: Dec. 28, 2023
The
presence
of
a
chiral
or
chirally
perturbed
chromophore
in
the
molecule
under
investigation
is
fundamental
requirement
for
appearance
circular
dichroism
(CD)
spectrum.
For
native
and
most
substituted
cyclodextrins,
this
condition
not
applicable,
because
although
chiral,
cyclodextrins
lack
group
therefore
have
no
characteristic
CD
spectra
over
220
nm.
reason
method
can
be
used
that
if
guest
has
right
proximity
to
cyclodextrin,
it
becomes
perturbed.
As
result,
complex
will
now
provide
signal,
phenomenon
called
induced
(ICD).
ICD
spectrum
clear
evidence
formation
complex,
spectral
sign
intensity
good
predictor
structure
complex.
By
varying
concentration
signal
changes,
resulting
saturation
curve,
from
these
data,
stability
constant
calculated
1:1
This
article
compares
NMR
spectroscopic
molecular
modeling
results
cyclodextrin
complexes
four
model
compounds:
nimesulide,
fenbufen,
fenoprofen,
bifonazole.
obtained
by
different
methods
show
agreement,
structures
estimated
are
supported
data
modeling.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(48), P. 45844 - 45853
Published: Nov. 20, 2023
In
the
pursuit
of
enhancing
catalytic
potential
Wells–Dawson
(WD)
polyoxometalate
(POM)
while
addressing
its
solubility
challenges,
this
study
focuses
on
devising
a
sustainable
catalyst
that
operates
effectively
in
aqueous
environments.
Leveraging
cyclodextrin
(CD)
polymer
chemistry
conjunction
with
3D
printing
technology,
CD
nanosponge,
recognized
for
interaction
POMs
and
molecular
shuttle
attributes,
is
synthesized
as
scaffold
WD
immobilization.
Through
integration
into
3D-printed
monolith
framework,
supported
species
becomes
embedded
within
structure,
facilitating
application.
Extensive
characterization
encompassing
X-ray
diffraction,
thermogravimetric
analysis,
Fourier
transform
infrared,
scanning
electron
microscopy/energy-dispersive
system,
elemental
mapping
compression
testing
confirms
structural
integrity
viability
resulting
catalyst.
The
assessment
developed
Knoevenagel
condensation
reaction
settings
demonstrates
enhanced
reusability
attributed
to
encapsulation
matrix.
Notably,
hot
filtration
test
provides
empirical
evidence
heterogeneous
catalysis
mode,
further
underpinning
catalyst's
performance
applications.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(49), P. 19632 - 19640
Published: Nov. 27, 2024
To
address
the
challenge
of
chiral
recognition
in
terms
efficiency
and
generality,
we
propose
a
novel
fluorescence
sensing
approach
by
rationally
designing
metal-ion-responsive
molecular
tweezers.
The
flexible
adaptable
tweezers
enable
facile
31
structurally
varied
primary
amine
compounds,
including
amino
acids,
acid
esters,
amines.
Notably,
upon
stimulation
zinc
ions,
demonstrate
higher
enantioselective
response.
Combined
density
functional
theory
calculations
reveal
that
mechanism
relies
on
differential
reaction
rates
potential
hydrogen-bonding
interactions
between
two
enantiomers
receptor,
which
results
one
forming
more
abundant,
stable,
rigid
complex
with
resulting
significant
increase
intensity
enantioselectivity.
stimuli-responsive
provides
strategy
for
precise
stereocontrol
universality
recognition,
offering
promising
tool
applications
various
fields.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(45)
Published: Dec. 1, 2023
Abstract
In
this
study,
we
employ
mechanochemistry
as
an
innovative
strategy,
using
a
Planetary
Mill,
to
obtain
supramolecular
structures
in
the
solid
state
between
Curcumin
(Cur)
and
β‐cyclodextrin
(βCD),
exploring
different
parameters
such
jars
balls
material
(stainless
steel
versus
zirconium
oxide),
milling
time,
well
effect
on
imposing
Cur:βCD
molar
ratios.
Our
findings
demonstrate
that
regardless
of
used,
same
interactions
Cur
βCD
seem
be
promoted.
However,
depending
ratio,
modes
are
produced
resulting
inclusion
complexes
(ICs)
or
non‐inclusion
(non‐ICs)
by
partial
total
amorphization
both
βCD.
Independently
type
complex
obtained
(ICs/or
non‐ICs),
high
content
was
quantified
all
systems,
achieving
up
342
mg
per
mmol
βCD,
along
with
enhancement
aqueous
solubility.
The
1
:
2
showed
highest
solubility
(around
10‐times
more
soluble
than
milled
Cur).
our
conditions,
optimum
time
form
60
min.
stability
directly
related
extent
encapsulation
inside
cavity.
Drug Development and Industrial Pharmacy,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: March 26, 2024
Objective:
This
research
aimed
to
investigate
the
application
of
coaxial
electrospun
method
for
production
natural
extracts
(papaya
leaf
extract)
fibre
films.
was
achieved
through
utilising
different
polymers
and
with
a
focus
on
conductivity
viscosity
polymer
solutions
as
critical
parameters
generate
successful
fibres.
Significance:
Electrospinning
is
promising
trending
manufacturing
incorporating
thermolabile
herbal
using
features.
However,
complexity
electrospinning
process
feasibility
product
required
precise
scrutiny.
Methods:
The
solution
(conductivity
viscosity)
were
evaluated
by
employing
various
ratios
Eudragit
L100
(EL100)
L100-55
(EL100-55)
pre-spinning
polymeric
blend
solutions.
ambient
optimised.
Following
that,
in-silico
physicochemical
properties
phytochemical
marker,
rutin,
illustrated
SwissADME
web
tool.
Both
freeze-dried
Carica
papaya
extract
its
produced
films
characterised
Scanning
Electron
Microscopy
(SEM),
Attenuated
Total
Reflectance
Fourier
Transform
Infrared
(ATR-FTIR),
polarised
light
microscopy,
X-Ray
Powder
Diffraction
(XRPD).
Results:
optimal
values
(≈40-44
×
10−4
S/m)
(≈32-42
10−3
Pa·s)
determined
producing
evenly
distributed
small
diameters
in
SEM
images.
These
significance
highlighted
acquiring
maintaining
adequate
tangential
stress
elongation,
which
would
consequently
affect
morphology
diameter
fibres
formed.
Conclusion:
In
conclusion,
solution,
process,
are
significant
developing
into
via
technology,
this
includes
electrospinning.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e31060 - e31060
Published: May 10, 2024
Resulted
from
the
severe
side
effects,
development
of
inexpensive,
simple
and
sensitive
method
for
amethopterin
(ATP,
an
antineoplastic
drug)
is
very
important
but
it
still
remains
a
challenge.
In
this
work,
low
cost
nanohybrid
composed
carbon
nanobowl
(CNB)
β-cyclodextrins
(β-CD)
(CNB-CD)
was
prepared
with
autopolymerization
way
applied
as
electrode
material
to
develop
novel
electrochemical
sensor
ATP.
Scanning-/transmission-
electron
microscopy,
Fourier
transform
infrared
spectrum,
photographic
image
technologies
were
utilized
characterize
morphologies
structure
as-prepared
CNB
CNB-CD
materials.
On
basic
coordination
advantages
(prominent
electrical
property
surface
area)
β-CD
(superior
molecule-recognition
solubility
capabilities),
modified
exhibits
superior
sensing
performances
toward
ATP,
detection
limit
0.002
μM
coupled
larger
linearity
0.005-12.0
are
obtained.
addition,
offers
desirable
repeatability,
stability,
selectivity
practical
application
property,
confirming
that
proposal
may
have
applications
in
determination
Journal of Materials Chemistry C,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Chirality
and
chiral
phenomena
associated
with
electromagnetic
waves
universally
arise
across
many
different
forms,
which
involve
transitions
between
states
opposite
symmetries.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(43), P. 31820 - 31824
Published: Jan. 1, 2024
A
pH-sensitive
fluorane
dye
was
developed
to
be
reacted
with
chiral
molecules
through
an
aldimine
condensation
reaction.
After
the
mixing
operation,
features
of
detected
could
facilely
determined
by
spectral
analysis.
Quinine,
a
natural
alkaloid
discovered
several
centuries
ago,
has
been
widely
used
as
an
anti-malarial
drug
and
bitter
food
additive.
However,
overconsumption
would
result
in
quinine
poisoning.
Herein,
we
presented
simple,
reusable,
cost-effective
electrochemical
sensor
for
detection,
utilizing
indicator
displacement
assay
(IDA)
with
β-cyclodextrin/poly(N-acetylaniline)/graphene-modified
glassy
carbon
(GC)
electrode.
Graphene
was
deposited
onto
the
electrode
surface
through
cyclic
voltammetry
(CV)
electroreduction
to
enhance
electron
transfer
properties.
The
poly(N-acetylaniline)
film
introduced
inhibit
non-special
absorption
of
methylene
blue
(MB).
β-cyclodextrin
(β-CD)
molecules
were
modified
on
using
chronoamperometry
provide
binding
site
MB(probe)/quinine(target).
Through
competitive
host-guest
interaction,
displaced
MB
molecule
from
β-CD
cavity.
We
employed
differential
pulse
(DPV),
(CV),
proton
nuclear
magnetic
resonance
(1H
NMR),
scanning
microscopy
(SEM),
impedance
analysis
(EIS),
Fourier
transform
infrared
(FTIR)
verify
successful
construction
sensor.
also
displayed
superior
selectivity
over
common
interfering
molecules,
satisfactory
reusability
upon
reincubation
solution,
good
reproducibility
consistent
fabrication
method,
high
stability
acceptable
peak
current
decrease
within
21
days.
To
our
knowledge,
this
is
first
time
integrate
recognition
determination.
In
light
IDA
design
strategy,
anticipate
that
work
will
inspire
innovative
engineering
methods
detection
fields
clinical
analysis,
safety,
environmental
monitoring.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
25(1), P. 412 - 412
Published: Dec. 28, 2023
The
presence
of
a
chiral
or
chirally
perturbed
chromophore
in
the
molecule
under
investigation
is
fundamental
requirement
for
appearance
circular
dichroism
(CD)
spectrum.
For
native
and
most
substituted
cyclodextrins,
this
condition
not
applicable,
because
although
chiral,
cyclodextrins
lack
group
therefore
have
no
characteristic
CD
spectra
over
220
nm.
reason
method
can
be
used
that
if
guest
has
right
proximity
to
cyclodextrin,
it
becomes
perturbed.
As
result,
complex
will
now
provide
signal,
phenomenon
called
induced
(ICD).
ICD
spectrum
clear
evidence
formation
complex,
spectral
sign
intensity
good
predictor
structure
complex.
By
varying
concentration
signal
changes,
resulting
saturation
curve,
from
these
data,
stability
constant
calculated
1:1
This
article
compares
NMR
spectroscopic
molecular
modeling
results
cyclodextrin
complexes
four
model
compounds:
nimesulide,
fenbufen,
fenoprofen,
bifonazole.
obtained
by
different
methods
show
agreement,
structures
estimated
are
supported
data
modeling.
