Biomimetic cascade intelligent paper chip sensor based on bimetallic porphyrin-based covalent organic framework with triple-enzyme mimetic activities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151628 - 151628

Published: April 25, 2024

Language: Английский

---

Infectious and Inflammatory Microenvironment Self‐Adaptive Artificial Peroxisomes with Synergetic Co‐Ru Pair Centers for Programmed Diabetic Ulcer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: Aug. 3, 2024

Abstract Complex microenvironments with bacterial infection, persistent inflammation, and impaired angiogenesis are the major challenges in chronic refractory diabetic ulcers. To address this challenge, a comprehensive strategy highly effective integrated antimicrobial, anti‐inflammatory, accelerated will offer new pathway to rapid healing of infected Here, inspired by tunable reactive oxygen species (ROS) regulation properties natural peroxisomes, work reports design infectious inflammatory self‐adaptive artificial peroxisomes synergetic Co‐Ru pair centers (APCR) for programmed ulcer therapy. Benefiting from synergistic Co Ru atoms, APCR can simultaneously achieve ROS production metabolic inhibition sterilization microenvironment. After disinfection, also eliminate alleviate oxidative stress microenvironment promote wound regeneration. The data demonstrate that combines antibacterial, provascular regeneration capabilities, making it an efficient safe nanomedicine treating foot ulcers via treatment pathway. This expects synthesizing bifunctional enzyme‐like provide promising path construct catalytic materials complex ulcers, trauma, or other infection‐caused diseases.

Language: Английский

---

Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151756 - 151756

Published: April 30, 2024

Language: Английский

---

Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Language: Английский

---

ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize

Language: Английский

---

Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic‐Resistant Biofilms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 5, 2024

Antibiotic-resistant pathogens have become a global public health crisis, especially biofilm-induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)-adaptive therapeutic strategies are urgently demanded to combat antibiotic-resistant biofilms. Here, inspired by the fascinating biological structures functions of phages, de novo design spiky Ir@Co

Language: Английский

---

Amide bonded polymeric carbon nitride for photocatalytic O2 activation and NO oxidation

Applied Catalysis B Environment and Energy, Journal Year: 2024, Volume and Issue: 353, P. 124022 - 124022

Published: April 24, 2024

Language: Английский

---

Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 20, 2025

Abstract Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms intracellular antioxidant defense systems, we propose de novo design an artificial antioxidase Ru-doped layered double hydroxide (Ru-hydroxide) for efficient redox homeostasis bone regeneration. Our studies demonstrate that Ru-hydroxide consists hydroxyls-synergistic monoatomic Ru centers, which efficiently react with collaborate hydroxyls rapid proton electron transfer, thus exhibiting efficient, broad-spectrum, robust ROS scavenging performance. Moreover, can effectively sustain cell viability osteogenic differentiation in elevated environments, modulating microenvironment during tissue regeneration male mice. We believe this development offers a promising avenue designing antioxidase-like materials to treat various inflammation-associated disorders, arthritis, diabetic wounds, enteritis, fractures.

Language: Английский

---

A robust electrochemical biosensor with cascade cleavage amplification mediated Pt@CeO2 nanoprobe machine for ultrasensitive microRNA-21 assay

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113172 - 113172

Published: Feb. 1, 2025

Language: Английский

---

Delocalization Engineering of Heme‐Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(15)

Published: Feb. 19, 2024

Abstract Developing artificial enzymes based on organic molecules or polymers for reactive oxygen species (ROS)‐related catalysis has broad applicability. Herein, inspired by porphyrin‐based heme mimics, we report the synthesis of polyphthalocyanine‐based conjugated (Fe‐PPc‐AE) as a new porphyrin‐evolving structure to serve efficient and versatile augmented catalysis. Owing structural advantages, such enhanced π‐conjugation networks π‐electron delocalization, promoted electron transfer, unique Fe−N coordination centers, Fe‐PPc‐AE showed more ROS‐production activity in terms Vmax turnover numbers compared with (Fe‐PPor‐AE), which also surpassed reported state‐of‐the‐art their activity. More interestingly, changing reaction medium substrates, revealed significantly improved environmental adaptivity many other ROS‐related biocatalytic processes, validating potential replace conventional (poly)porphyrin‐based mimics catalysis, biosensors, biotherapeutics. It is suggested that this study will offer essential guidance designing polymers.

Language: Английский

---