Polysaccharides from Lonicera japonica Thunb.: Extraction, purification, structural features and biological activities—A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136472 - 136472

Published: Oct. 15, 2024

Language: Английский

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Solubilization techniques used for poorly water-soluble drugs

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

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Ionic liquids-based technologies as a sustainable agent for removing heavy metals and organic pollutants for water purification: A review

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 71, P. 107367 - 107367

Published: March 1, 2025

Language: Английский

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Metal and metal oxide nanoparticles combined with ionic liquids and deep eutectic solvents and their practices in drug extraction and environmental processes: A review

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126955 - 126955

Published: Jan. 1, 2025

Language: Английский

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Review of ionic liquid and ionogel-based biomaterials for advanced drug delivery

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103244 - 103244

Published: June 26, 2024

Ionic liquids (ILs) play a crucial role in the design of novel materials. The ionic nature ILs provides numerous advantages drug delivery, acting as green solvent or active ingredient to enhance solubility, permeability, and binding efficiency drugs. They could also function structuring agent development nano/micro particles for including micelles, vesicles, gels, emulsion, more. This review summarize IL-based gel structures with their advanced delivery applications. first part focuses on formulation applications delivery. second offers comprehensive overview recent gel. It aims offer new perspectives attract more attention open up avenues biomedical gels.

Language: Английский

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Multifunctional Roles of Ionic Microenvironments in the Preparation, Modification, and Application of g‐C₃N₄

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract As a visible light‐responsive metal‐free polymer semiconductor, graphitic carbon nitride (g‐C 3 N 4 ) has garnered increasing attention in photocatalysis but needs structural modification and functional enhancement. Recently, the rational design of ionic microenvironments (IMEs) by leveraging tunability various ions to endow catalysts with tailored functionalities been elevated hot direction. To elucidate their respective effects on g‐C , IMEs are categorized into three types, namely plasma IMEs, organic inorganic according criteria external field dependence, cation type, application scenarios. These promotions include facilitated preparation, diversified modifications, improved efficiencies. First, participate constructing functionalized microenvironment through dynamic interactions precursor during facilitating customization, crystal nucleation growth, surface performance enhancement, process cleanliness. Second, create tunable for post‐modification functioning as an electron reservoir, modifier, substrate adsorbent, stabilizer. Lastly, synergistic effect between IME they achieve targeted product regulation, enhanced chemical stability, efficient adsorption, potential fields like catalysis, energy storage, gas adsorption. Also, limitations, challenges, prospects strategies discussed, offering systematic insights IMEs‐based structure‐activity relationships 4.

Language: Английский

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Anti-aging and Anti-inflammatory Fulfilled through the Delivery of Supramolecular Bakuchiol in Ionic Liquid

Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100093 - 100093

Published: Jan. 1, 2025

Language: Английский

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Potential Antioxidant and Anti-inflammatory Effects of Astaxanthin Ionic Liquid Liposomes

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Astaxanthin is an antioxidant with extremely high activity. However, the stability and solubility of free astaxanthin are poor. Therefore, we prepared astaxanthin-betaine (ASTA-Bet) ionic liquid liposomes through a combination theoretical calculations experimental research studied their physicochemical properties biological effects. This liposome has good skin permeability. The cumulative permeability ASTA-Bet 22.95 times that 2.41 liquid. particle size was 117.2 nm, did not change significantly after 28 days storage, indicating stability. Compared astaxanthin, activity can exert anti-inflammatory effects by regulating TGF-β1/smad2/smad3 pathway damaged ultraviolet radiation, which may contribute to resistance radiation damage. it be used as raw material develop cosmetics antiaging functions.

Language: Английский

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Deciphering the role of flutamide, fluorouracil, and furomollugin based ionic liquids in potent anticancer agents: Quantum chemical, medicinal, molecular docking and MD simulation studies

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102029 - 102029

Published: Jan. 1, 2025

Language: Английский

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The Physics of Antimicrobial Activity of Ionic Liquids

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(27), P. 7075 - 7083

Published: July 1, 2024

The bactericidal potency of ionic liquids (ILs) is well-established, yet their precise mechanism action remains elusive. Here, we show evidence that the ILs primarily involves permeabilization bacterial cell membrane. Our findings reveal exert effects by directly interacting with lipid bilayer and enhancing membrane dynamics. Lateral diffusion accelerated, which in turn augments permeability, ultimately leading to death. Furthermore, our results establish a significant connection: an increase alkyl chain length correlates notable enhancement both lateral antimicrobial potency. This underscores compelling correlation between dynamics effectiveness, providing valuable insights for rational design optimization IL-based agents healthcare applications.

Language: Английский

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