Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis DOI Open Access
Zhijun Lin, Wanyan Wang, Dingxin Liu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 21, 2024

Abstract Interstitial cystitis (IC) is a chronic inflammatory disorder characterized by recurring severe pain in the bladder and surrounding pelvic areas, lacking timely diagnostic therapeutic options. Here, we propose unitary theranostic nanocluster-antibody-drug conjugate (NADC) covalently placing dihydroorotate dehydrogenase inhibitors (DHODHi) ultrasmall gold quantum clusters (AuQCs) on nerve growth factor (NGF) antagonistic antibody with simultaneous X-ray computed tomographic near-infrared fluorescence imaging contrasts. Combining anti-inflammatory effects from all individual components, intravesical NADC specifically homed to mucosal lesions capably alleviated inflammation chronic, acute, prophylactic IC models of rats, as revealed behavioral pathological evaluations. Transcriptomics unveiled cytokine modulation concomitant inhibition perturbed IL-17, NF-κB, TNF, JAK-STAT signaling pathways. Interestingly, reconstructed host microbiota differentially varying pro-inflammatory bacteria diversities. Distinct conventional nanoparticles conjugated antibodies drugs, relies framework represents state-of-the-art category precision agents translational potential for diagnosing treating patients.

Language: Английский

Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review DOI Creative Commons

Alshayma N. Al-Thani,

Asma Ghafoor Jan,

Mohamed Abbas

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

Citations

67

Nanostructures and nanoparticles as medical diagnostic imaging contrast agents: A review DOI
Nikiwe Mhlanga,

Ntsoaki Mphuthi,

Hendriëtte Van der Walt

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102233 - 102233

Published: Aug. 5, 2024

Language: Английский

Citations

14

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications DOI Creative Commons
Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Language: Английский

Citations

11

How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy? DOI Open Access
Emira D’Amico, Gitana María Aceto, Morena Petrini

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 592 - 592

Published: Jan. 12, 2025

Periodontitis is a prevalent inflammatory disease affecting the supporting structures of teeth, leading to gum recession, tooth loss, and systemic health complications. Traditional diagnostic methods treatments, such as clinical evaluation scaling, often fall short in early detection targeted therapy, particularly complex or advanced cases. Recent advancements nanomedicine offer promising solutions for improving both diagnosis treatment periodontitis. Nanoparticles, liposomes, quantum dots, nanorods, have demonstrated potential enhancing accuracy by enabling more precise periodontal pathogens biomarkers at molecular level. Furthermore, nanotechnology-based therapies, including drug delivery systems antimicrobial agents, localized controlled release therapeutic efficacy reducing side effects compared conventional treatments. This study reviews current applications periodontitis, highlighting its revolutionize care detection, times, outcomes.

Language: Английский

Citations

1

Exploring the fluorescence properties of tellurium-containing molecules and their advanced applications DOI
Avtar Singh, Jaspreet S. Dhau, Rajeev Kumar

et al.

Physical Chemistry Chemical Physics, Journal Year: 2024, Volume and Issue: 26(13), P. 9816 - 9847

Published: Jan. 1, 2024

This review article explores the fascinating realm of fluorescence using organochalcogen molecules, with a particular emphasis on tellurium (Te). The discussion encompasses underlying mechanisms, structural motifs influencing fluorescence, and applications these intriguing phenomena. not only elucidates current state knowledge but also identifies avenues for future research, thereby serving as valuable resource researchers enthusiasts in field chemistry focus Te-based molecules. By highlighting challenges prospects, this sparks conversation transformative potential Te-containing compounds across different fields, ranging from environmental solutions to healthcare materials science applications. aims provide comprehensive understanding distinct behaviors exhibited by compounds, contributing insights evolving landscape chalcogen-based research.

Language: Английский

Citations

8

Emerging Head and Neck Tumor Targeting Contrast Agents for the Purpose of CT, MRI, and Multimodal Diagnostic Imaging: A Molecular Review DOI Creative Commons

Jonathan M. Neilio,

Daniel Thomas Ginat

Diagnostics, Journal Year: 2024, Volume and Issue: 14(15), P. 1666 - 1666

Published: Aug. 1, 2024

The diagnosis and treatment of head neck tumors present significant challenges due to their infiltrative nature diagnostic hindrances such as the blood-brain barrier. intricate anatomy region also complicates clear identification tumor boundaries assessment characteristics.

Language: Английский

Citations

5

Nanobiotechnology: traditional re-interpreting personalized medicine through targeted therapies and regenerative solutions DOI
S. Chattopadhyay, Arunava Goswami, Moumita Sil

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0

Tannic acid-based bio-MOFs with antibacterial and antioxidant properties acquiring non-hemolytic and non-cytotoxic characteristics DOI
Nurettin Şahiner, Olgun Güven, Şahin Demirci

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114669 - 114669

Published: March 1, 2025

Language: Английский

Citations

0

Characterization of a radiation detector based on opaque water-based liquid scintillator DOI

Jaime Apilluelo,

L. Asquith,

E.F. Bannister

et al.

Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, Journal Year: 2024, Volume and Issue: 1071, P. 170075 - 170075

Published: Nov. 19, 2024

Language: Английский

Citations

2

Effect of aspect ratio on the x-ray attenuation of nanoparticles: A theoretical study DOI
Rezvan Ravanfar Haghighi, Sabyasachi Chatterjee, Fariba Zarei

et al.

Radiation Physics and Chemistry, Journal Year: 2024, Volume and Issue: 218, P. 111626 - 111626

Published: Feb. 21, 2024

Language: Английский

Citations

1