Recent progress of soft and bioactive materials in flexible bioelectronics

Cyborg and Bionic Systems, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical chemical mismatch between implants ultimately results device failure corrosion by biofluids associated foreign body response. Of particular interest development of bioactive materials at level chemistry mechanics high-performance, minimally invasive function, simultaneously tissue-like compliance vivo biocompatibility. This review summarizes most recent progress these purposes, an emphasis on material properties such as response, integration schemes biological tissues, their use bioelectronic platforms. The article begins overview emerging classes platforms bio-integration proven utility live animal models, high performance different form factors. Subsequent sections various flexible, soft materials, ranging from self-healing hydrogel/elastomer bio-adhesive composites materials. Additional discussions highlight examples active systems support electrophysiological mapping, stimulation, drug delivery treatments related diseases, spatiotemporal resolutions span cellular organ-scale dimension. Envisioned applications involve advanced brain, cardiac, other organ systems, offer stability human subjects models. Results will inspire continuing advancements functions benign thus yielding therapy diagnostics healthcare.

Language: Английский

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Ischemic Area‐Targeting and Self‐Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real‐time monitoring drug aggregation the MIRI region remains an open question. Herein, delivery system, hesperadin ICG assembled PLGA‐Se‐Se‐PEG‐IMTP (HI@PSeP‐IMTP), designed to deliver for vivo optical imaging tracking ameliorate MIRI. The peak nanoprobes monitored by near‐infrared fluorescence photoacoustic imaging. maximal signals HI@PSeP‐IMTP group rise ≈32% 40% respectively compared with that HI@PSeP group. Moreover, effectively mitigates due synergistic integration diselenide bonds hesperadin, which can eliminate ROS suppress cardiac inflammation. Specifically, expression levels p‐CaMKII, p‐IκBα, p65 demonstrate reduction 30%, 46%, 42% PBS Collectively, provides new insights into development drugs integrating diagnosis treatment

Language: Английский

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Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications

Applied Physics Reviews, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 1, 2025

Smart biomaterials have significantly impacted human healthcare by advancing the development of medical devices designed to function within tissue, mimicking behavior natural tissues. While intelligence has evolved from inert active over past few decades, smart take this a step further making their surfaces or bulk respond based on interactions with surrounding tissues, imparting outcomes similar tissue functions. This interaction helps in creating stimuli-responsive biomaterials, which can be useful engineering, regenerative medicine, autonomous drug delivery, orthopedics, and much more. Traditionally, material engineering focused refining static properties accommodate them body without evoking an immune response, was major obstacle unrestricted operation. review highlights explains various approaches currently under research for developing that tune responses bodily factors like temperature, pH, ion concentration external magnetism, light, conductivity. Applications soft hard 4D printing, scaffold design are also discussed. The advanced application microfluidics, organ-on-a-chip models, extensively benefits intrinsic discussed below. elaborates how biomaterial could revolutionize biosensor applications, thereby improving patient care quality. We delineate limitations key challenges associated providing insights into path forward outlining future directions next-generation will facilitate clinical translation.

Language: Английский

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Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 460 - 482

Published: Nov. 29, 2023

Ischemic cardiomyopathy (ICM) affect millions of patients globally. Decellularized extracellular matrix materials (dECM) have components, microstructure and mechanical properties similar to healthy cardiac tissues, can be manufactured into various forms implantable biomaterials including injectable hydrogels or epicardial patches, which been extensively reported attenuate pathological left ventricular remodeling maintain heart function. Recently, dECM medical devices for ICM treatment approved clinical use studied in trials, exhibiting considerable translation potential. Cells, growth factors other bioactive agents incorporated with different improve the therapeutic outcomes. In addition, more detailed aspects biological effects mechanisms are being revealed. This review summarized recent advances from variable sources repair, extraction matrix, cell integration, smart manufacturing patch materials, their applications. Besides, this provides an outlook on cutting-edge development directions field.

Language: Английский

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Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2023

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109893 - 109893

Published: April 17, 2024

Language: Английский

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Multifunctional polyurethane materials in regenerative medicine and tissue engineering

Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(7), P. 102053 - 102053

Published: June 17, 2024

Facing the problems encountered in contemporary hard and soft tissue repair, need for better solutions has never been so pressing. Traditional repair methods often fall short, leading to disappointing therapeutic outcomes complications. To address associated with engineering, polyurethane stands out because of its remarkable adaptability healing potential. This review embarks on a journey through essential properties diverse classifications polyurethane, unveiling modification strategies that amplify efficacy. Beyond process mending gaps, capability as sophisticated drug delivery system is explored offer glimpse into versatile applications. Most notably, cutting-edge advancements clinical trials bridging voids both are discussed. The present explores future bio-interface providing wave inventive poised redefine landscape regenerative medicine.

Language: Английский

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Peptide‐Grafted Waterborne Polyurethane With Enhanced Biocompatibility and Mechanical Properties for Biomedical Applications

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

ABSTRACT The incorporation of fillers into waterborne polyurethane (WPU) can endow the composites with improved physicochemical and physiological properties for biomedical applications. Silk fibroin possesses excellent mechanical biocompatibility owing to its unique hierarchical structure comprising β‐sheet crystallites amorphous matrix. To mimic structure, a crystalline tetrapeptide Gly‐Ala‐Gly‐Ala (GAGA) derived from repetitive segments primary sequence fibroins was grafted onto WPU backbone. tetrapeptides aggregated via additional hydrogen bonds form domains, which served as physical crosslinking points significantly improve WPU. Compared pristine WPU, modification enhanced maximum tensile strength (from 13.1 25.4 MPa) hydrophilicity (the water contact angle 80.6° 38.8°). In addition, modified optimal proportion remained structurally stable under environments showed including good cell protein adhesion, noncytotoxicity, nonhemolysis. performance confirms effectiveness peptides in sheds light on potential

Language: Английский

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An Endothelium‐Mimicking, Healable Hydrogel Shield for Bioprosthetic Heart Valve with Enhanced Intravascular Biocompatibility

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Bioprosthetic heart valves (BHVs) for transcatheter replacement often face deterioration due to thrombosis, inflammation, and calcification, which are irreversible. Here, a multidimensional endothelium‐mimicking healable hydrogel shielded BHV that not only withstand the complex valvular physiological hemodynamic environment but also able reverse damage‐induced structural degeneration by in situ healing is proposed. Polydopamine/selenocystamine nanoparticles with photothermal effect embedded achieve light‐triggered catalytic nitride oxide generation polyvinyl alcohol coating on surface. Additionally, platelet inhibitor Tirofiban encapsulated shield block acute coagulation cascade early stage after implantation. A rodent intravascular leaflet‐like implantation model developed reveal long‐term hemocompatibility of BHVs abdominal aorta. The exhibit enhanced antithrombotic properties, reduced superior endothelialization, improved vascular patency. Transcriptome analysis indicates better endothelial functions BHVs. Moreover, maintains both mechanical properties biological healing, facilitated great fast re‐endothelialization. Collectively, strategy provides new insight preventing reversing damage instead solely replacement.

Language: Английский

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Polyurethane‐Based Shape Memory Compression Stockings with Antimicrobial and Pressure Regulating Properties for the Relief of Chronic Venous Disease

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Chronic venous disease (CVD) causes a heavy social and economic burden, which not only seriously diminishes the quality of life but also increases healthcare costs for patients. Herein, compression stocking fabricated with polyurethane fibers is developed, exhibits excellent antimicrobial shape memory properties. In particular, introduction 1,2‐hydroxyethylpiperazine (HEP) dramatically shortens relaxation time effectively promotes properties polyurethane. Furthermore, wet spinning knitting methods are applied to obtain stockings, whose interfacial pressure ranges from 8 35 mmHg can be regulated via initial tension trigger temperatures as needed. addition, stockings demonstrate properties, achieving an inactivation rate 99.99% against S. aureus E. coli , while superior cytocompatibility negligible skin irritation guarantee its biomedical applications. Overall, manage solve two major problems regulation bacterial infection CVD patients, highly important care this public health disease.

Language: Английский

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Selenium-containing polyurethane nanofibers with MnO2 nanoparticles and gelsevirine promote diabetic wound healing by modulation of ROS and inflammation

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214289 - 214289

Published: March 1, 2025

Language: Английский

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