Formulation and Evaluation of Licorice-Extract-Enhanced Chitosan, PVA, and Gelatin-Derived Hydrogels for Wound Dressing DOI Creative Commons
Maria Mujahid, Muhammad Zubair, Asma Yaqoob

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 439 - 439

Published: April 23, 2025

Wound infections remain a significant clinical challenge, impeding healing and causing deterioration. Recently, multifunctional hydrogel dressings have gained interest as an effective treatment to treat efficiently enhance wound recovery. The present research is focused on the development of composite hydrogels comprising chitosan (CS), polyvinyl alcohol (PVA), gelatin (GEL) licorice extract (LE), using freeze gelation technique. resulting CS/PVA/GEL incorporating LE were characterized by FTIR, XRD SEM. FTIR analysis confirmed presence specific functional groups within molecules. exhibited amorphous nature hydrogels. SEM revealed that increasing CS ratio in created more porous structure with smaller pore size. All demonstrated oxygen permeability, which crucial for process. Among synthesized hydrogels, MM-2 containing PVA (20 mL) (4 superior performance water retention capacity 440% moisture content 91%. This exceptional result can be attributed higher proportion material’s structure, enhances its hydrophilic properties. showed good antibacterial potential against three selected strains bacteria including Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). hydrogels’ cytotoxicity levels assessed through hemolysis assay results all non-toxic. hydrolytic breakdown interconnected components slow degradation, making them appropriate long-term treatment. Specifically, MM-4 74% degradation rate displayed 75% antioxidant activity, indicating effectiveness chronic applications. These characteristics CS/PVA/GEL/LE-derived suggest their use promising candidate care

Language: Английский

Improved wound care via novel dextran and boric acid loaded wound healing gel in excision mice wound model DOI

Nosheen Maqbool,

Zakir Ali,

Sibgha Batool

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106586 - 106586

Published: Jan. 1, 2025

Language: Английский

Citations

4
Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings DOI Creative Commons

A. S. Alberts,

Dana-Ionela Tudorache,

Adelina-Gabriela Niculescu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

Citations

4
Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care DOI Open Access

A. S. Alberts,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

et al.

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133

Published: March 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Language: Английский

Citations

3
Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care DOI
Sabine Szunerits, Andrew E.‐Y. Chuang, Jen‐Chang Yang

et al.

Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gap, and safety assessment DOI
Shubhrajit Mantry,

Ashutosh Behera,

Shaktiprasad Pradhan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135410 - 135410

Published: Sept. 6, 2024

Language: Английский

Citations

4
The Printed Path to Healing: Advancing Wound Dressings through Additive Manufacturing DOI Open Access
Joana Duarte, Ana P. Piedade, Bruno Sarmento

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Wound care challenges healthcare systems worldwide as traditional dressings often fall short in addressing the diverse and complex nature of wound healing. Given conventional treatments limitations, innovative alternatives are urgent. Additive manufacturing (AM) has emerged a distinct transformative approach for developing advanced dressings, offering unprecedented functionality customization. Besides exploring AM processes state‐of‐the‐art, this review comprehensively examines application to produce cellular‐compatible bioactive, therapeutic agent delivery, patient‐centric, responsive dressings. This distinguishes itself from published literature by covering variety types summarizing important data, including used materials, process/technology, printing parameters, findings vitro, ex vivo, vivo studies. The prospects enhancing healing outcomes also analyzed translational cost‐effective manner.

Language: Английский

Citations

0
Challenges and considerations in liposomal hydrogels for the treatment of infection DOI Creative Commons
Željka Vanić, May Wenche Jøraholmen, Nataša Škalko‐Basnet

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 10, 2025

Liposomal hydrogels are novel drug delivery systems that comprise preformed liposomes incorporated in destined for mostly localized therapy, herewith antimicrobial therapy. The formulation benefits from versatility of as lipid-based nanocarriers enable various antimicrobials different lipophilicities, and secondary vehicle, hydrogel, assures better retention time at the infection site. Especially an era alarming resistance, efficient therapy avoids systemic exposure related side effects is crucial. We provide overview liposomal were developed superior infections sites, with focus on skin vaginal infections. review summarizes challenges site most common infection-causing pathogens offers commentary relevant features needs to optimize increase outcome. discuss impact composition, size, choice polymer-forming hydrogel outcome based literature own experience field. offer improved By fine-tuning well properties, formulations performance can be optimized targeting specific

Language: Английский

Citations

0
Mechanically robust, mouldable, dynamically crosslinked hydrogel flap with multiple functionalities for accelerated deep skin wound healing DOI

Hitasha Vithalani,

Harshil Dave,

Hemant Singh

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214195 - 214195

Published: Jan. 20, 2025

Language: Английский

Citations

0
Advanced Hydrogel Dressing with Zinc Oxide-Copper Oxide Nanocomposite for Effective Wound Management: Mechanochemistry, Antibacterial Efficacy, Cytocompatibility and Wound Healing Potentials DOI

Nasrin K Ramtan Gadaime,

Rabiatul Basria S. M. N. Mydin, G Ambarasan Govindasamy

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

Citations

0
Enhancing burn wound care with pre-crosslinked 3D-printed patches: Bromelain delivery and aloe vera bioactives integration for improved healing outcomes DOI Creative Commons
Francesco Patitucci,

Marisa Francesca Motta,

Olga Mileti

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125304 - 125304

Published: Feb. 1, 2025

Burn wounds remain a major clinical challenge due to the limitations of traditional dressings, which often fail address diverse needs patients and varying wound types. This study aimed advance burn care by developing 3D-printed patch incorporating natural bioactive compounds from bromelain aloe vera. The was formulated using pre-crosslinked chitosan alginate hydrogels ensure suitability for 3D printing subsequent use. Rheological analysis revealed weak gel behaviour shear-thinning properties, ensuring excellent printability. patches exhibited outstanding swelling controlled degradation (30 %), alongside notable antioxidant anti-inflammatory potential, with polyphenolic content 1.43 ± 0.07 mg CAE/g effective scavenging DPPH, ABTS, NO radicals, IC50 values 29.51 0.30, 10.31 0.28, 5.94 0.42 mg/mL, respectively. Bioactive were consistently released across various pH levels, supporting their therapeutic efficacy. Cell viability studies confirmed strong support cell growth, while in vitro scratch tests demonstrated biocompatibility promotion closure. Histological ex vivo models cellular necrosis protein denaturation characteristic wounds. Application significantly improved epidermal morphology enhanced proliferation markers such as Ki67 α-SMA, indicative accelerated healing. While further validation is needed, these findings underscore potential an innovative solution care, offering delivery healing outcomes compared conventional dressings.

Language: Английский

Citations

0