International Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 19(4), P. 548 - 564
Published: May 1, 2023
Language: Английский
Plants, Journal Year: 2025, Volume and Issue: 14(5), P. 755 - 755
Published: March 1, 2025
This review highlights the recent advancements in extraction techniques for bioactive compounds from natural sources, focusing on methodologies that enhance both efficiency and sustainability. Techniques such as pressurized hot water (PHWE), solid-state fermentation (SSF), ionic liquids (ILs), electrohydrodynamic (EHD) methods have shown significant potential improving yields while preserving bioactivity of target compounds. These innovative approaches offer advantages over traditional methods, including reduced energy consumption, minimal environmental impact, ability to extract thermosensitive PHWE EHD are particularly effective extracting antioxidants compounds, whereas SSF provides an environmentally friendly alternative by valorizing agro-industrial waste. Ionic liquids, although promising complex phytochemicals, face challenges related scalability economic feasibility. The adoption these advanced represents a shift toward more sustainable cost-effective processes, promoting discovery utilization high-value also contribute development eco-friendly, strategies align with green chemistry principles regulatory standards. However, further research technological required address existing limitations ensure widespread application industrial pharmaceutical sectors.
Language: Английский
Citations
1
Drugs, Journal Year: 2024, Volume and Issue: 84(2), P. 179 - 202
Published: Jan. 24, 2024
Language: Английский
Citations
6
Advanced Science, Journal Year: 2023, Volume and Issue: 11(5)
Published: Dec. 3, 2023
Abstract Traditional Chinese medicine (TCM) is widely used in clinical practice, including skin and gastrointestinal diseases. Here, a potential TCM QY305 (T‐QY305) reported that can modulate the recruitment of neutrophil colon tissue thus reducing cutaneous adverse reaction diarrhea induced by epidermal growth factor receptor inhibitors (EGFRIs). On another hand, T‐QY305 formula, through regulating features would highlight presence N‐QY305, subunit nanostructure contained T‐QY305, confirm its role as potentially being biomaterial conferring to pharmacodynamic features. records two patients are analyzed expressing demonstrate positive effect on simultaneous inhibition both animal models. The satisfying results obtained from lead further process isolation N‐QY305 order potency originates N‐QY305. Compared exhibits higher upon reactions. data represent promising candidate for diarrhea, meanwhile proposing new strategy nanostructures “ King ” formula basis.
Language: Английский
Citations
14
Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127681 - 127681
Published: Feb. 2, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3045 - 3065
Published: March 1, 2025
Abstract: Chinese herbal medicines and their extracts will produce nano-components of charcoal drugs after high-temperature carbonization, the process is similar to that carbon dots (CDs). medicine-derived CDs (CHM-CDs) are a new carbon-based nanomaterial with particle size less than 10 nm discovered in recent years. CHM-CDs possess range beneficial traits, such as minimal toxicity, strong water solubility, superior biocompatibility, remarkable photoluminescence capabilities. Additionally, they exhibit multifaceted pharmacological activity absence drug loading. Over past half-decade, numerous publications have presented evidence suggesting wide array effects. These primarily encompass hemostatic capabilities, neuroprotection, anti-infective, antitumor, immunomodulatory effects hypoglycemic activity. Notably, been associated circulatory system, digestive nervous immune endocrine urinary system skeletal system. This article systematically reviews modern potential mechanisms CHM-CDs, offering insights into current challenges proposing directions for future advancements. As such, it serves vital reference clinical application CHM-CDs. Keywords: medicines, dots, effects,
Language: Английский
Citations
0
Chinese Medical Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Nanozymes are a distinct category of nanomaterials that exhibit catalytic properties resembling those enzymes such as peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and glutathione (GPx). derived from Chinese herbal medicines the functions their enzyme mimics, while retaining specific medicinal herb (termed "herbzymes"). These nanozymes can be categorized into three main groups based on method synthesis: carbon dot nanozymes, polyphenol-metal extract nanozymes. The reported activities herbzymes include POD, SOD, CAT, GPx. This review presents an overview potential applications introduces novel concept herbzymes, provides comprehensive classification synthesis, discusses recent advances in biomedical applications. Furthermore, we also discuss significance research including primary challenges faced future development directions.
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(6), P. 100943 - 100943
Published: Feb. 7, 2024
Structural and functional explorations on bio-soft matter such as micelles, vesicles, nanoparticles, aggregates or polymers derived from traditional Chinese medicine (TCM) has emerged a new topic in the field of TCM. The discovery cross-scaled may provide unique perspective for unraveling effective material basis TCM well developing innovative biomaterials. Despite rapid rise TCM-derived matter, their hierarchical structure assembly mechanism must be unambiguously probed further in-depth understanding pharmacological activity. In this review, current assembled either small molecules macromolecules will introduced, particularly unambiguous elucidation with combined electron microscopic spectroscopic techniques depicted. pros cons each technique are also discussed. future challenges outlined, requirement precise situ structural determination is highlighted.
Language: Английский
Citations
3
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 10, 2024
Over the past few years, there has been a gradual increase in incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents notable peril to human existence wellbeing. Hawthorn, medicinal food homology plant belonging Crataegus genus Rosaceae family, holds great value various applications. Due long history use, effects, high safety profile, hawthorn garnered considerable attention plays crucial role treatment. Through integration modern network pharmacology technology traditional Chinese medicine (TCM), range anticancer active ingredients have predicted, identified, analyzed. Studies shown that such as vitexin, isoorientin, ursolic acid, maslinic along with extracts, can effectively modulate cancer-related signaling pathways manifest properties via diverse mechanisms. This review employs excavate potential hawthorn. By systematically integrating literature across databases PubMed CNKI, explores bioactive underlying mechanisms pathways, synergistic effects drug combinations, advancements novel delivery systems, ongoing clinical trials concerning hawthorn’s properties. Furthermore, highlights preventive health benefits prevention, offering valuable insights for treatment development TCM be used both edible purposes.
Language: Английский
Citations
3
Published: June 27, 2023
With the increasing demand for medicinal plants and shortage of resources, improving quality yield making more effective use has become an urgent problem to be solved. In process growth development plants, due threat various adversity, there are problems such as nutrient loss decline. Using traditional chemical pesticides control stress resistance will cause serious pollution environment even endanger human health. Therefore, it is necessary find suitable pesticide substitutes from natural ingredients. As important part microecology endophytes can promote improve hosts, accumulation active components hosts. Because a positive direct impact on host, metabolize rich ingredients, so researchers pay attention it. This paper reviews research in recent five years, aiming provide ideas developing microbial exploring products, providing help endophytes.
Language: Английский
Citations
8
Life, Journal Year: 2023, Volume and Issue: 13(8), P. 1695 - 1695
Published: Aug. 6, 2023
With the increasing demand for medicinal plants and shortage of resources, improving quality yield making more effective use has become an urgent problem to be solved. During growth plants, various adversities can lead nutrient loss decline. Using traditional chemical pesticides control stress resistance will cause serious pollution environment even endanger human health. Therefore, it is necessary find suitable pesticide substitutes from natural ingredients. As important part microecology endophytes promote improve tolerance hosts, accumulation active components hosts. Endophytes have a positive direct impact on host metabolize rich ingredients, so researchers pay attention them. This paper reviews research in past five years, aiming provide ideas developing microbial exploring products, providing help development endophytes.
Language: Английский
Citations
6