Recent Advances in Catalytic Nitrogen–Nitrogen Bond Formation Reactions

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(8), P. 5735 - 5778

Published: April 1, 2024

The lack of effective strategies for direct construction nitrogen–nitrogen bonds has hampered developments in the synthesis and application molecules containing hydrazine or azo motifs. Attracted by their properties both material science medicinal chemistry, more attention been drawn to this area, resulting fast growth design azaheterocycles substituted hydrazines. This review focuses on efficient catalytic approaches toward formation N–N N═N through different strategies, including oxidative dehydrogenation, nitrene-transfer reaction, reductive coupling, some other recently developed methods.

Language: Английский

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A facile method of treating spent catalysts via using solvent for recovering undamaged catalyst support

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0296271 - e0296271

Published: Jan. 2, 2024

The process of washing and removing crude oil from spent catalysts is a serious issue in both catalyst regeneration precious metals recovery. In this work, five different solvents with various polar aromatic properties were chosen to evaluate their impact on the support structure recovery oil-contaminated catalysts. After deoiling process, was analyzed by scanning electron microscopy, X-ray diffraction (XRD), Fourier transform-infrared spectroscopy, elemental analyzer, contact angle measurement, gas chromatography-mass spectrometry, inductively coupled plasma-atomic emission Brunauer Emmet Teller (BET) method. Our findings demonstrate that p -xylene kerosene are more effective than other solvents. This due oil’s similar polarity molecular nature p- xylene. Considering economical reason, better choice for compared as it affordable -xylene. XRD data show unaltered solvent treatment while BET reveals surface area pore volume significantly enhanced after process. These results imply very crucial step recycling, regeneration, reuse work significant developing sustainable approaches managing catalysts, minimizing waste environmental pollution.

Language: Английский

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Molecular Design, synthesis and anticancer activity of novel Pyrazolo[3,4-b]pyridine-based glycohybrid molecules

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108161 - 108161

Published: Jan. 17, 2025

Language: Английский

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Synthesis of Polynitrogen-Containing [6-5-6] Tricyclic Derivatives by N–N Bond Formation and Their Fluorescent Properties

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Polynitrogen-containing scaffolds are of major interest for many applications. To optimize and improve the potential these scaffolds, it is important to be able easily introduce modulate substituents, regardless number position nitrogen atoms in structure. Therefore, synthetic approach ideally requires mild experimental conditions an expanded scope application. this end, a versatile efficient synthesis [6-5-6] tricyclic derivatives pyridopyrazolopyrazine, dipyridopyrazole, pyridopyrazolopyrimidine types was undertaken at room temperature. Against all odds, key oxidative cyclization step successfully applied two electron-poor heteroaromatic partners, theoretical calculations were performed rationalize proposed mechanism N-N bond formation. Measurements fluorescence properties showed strong impact scaffold. Among seven families studied, pyridopyrazolopyrazine offers best terms brightness.

Language: Английский

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Sustainable Synthesis of N−N Bond Bearing Organic Frameworks by Advanced Heterogeneous Metal Catalysis

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 26(32)

Published: June 10, 2023

Abstract The most significant task in synthetic organic chemistry is developing reactions from a green and sustainable perspective. In these ways, heterogeneous catalysts are essential many reactions. Thus, this study focuses on the synthesis of N−N bond bearing frameworks, particularly aromatic azo compounds indazoles, using metal catalyst. Organic molecules containing nitrogen‐nitrogen bonds greatly sought after dyes, photochemical switches, food additives, bioactive chemicals due to industry human requirements. Finally, review provides an overview routes for formation by various catalytic systems.

Language: Английский

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Organo Mediated Sustainable Synthesis and In‐Silico Studies of Novel Benzisoxazole‐Chromene Acyl Hydrazones as AChE Inhibitors

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract A new class of benzisoxazole‐Chromene (BC) analogues containing acyl hydrazones BCA ( 5a ‐ 5m ) were obtained by the condensation different benzo hydrazides with BCs in good yield. All synthesized evaluated for their in‐silico activity against Acetylcholine Esterase (AChE). According to docking experiments, co‐crystallized ligand was outperformed derivatives 5e 4‐benzisoxazole‐chromene‐3‐(4hydroxyphenyl) acrylohydrazide), (7‐chloro,4‐hydroxy) and 5l (8‐methyl, m ‐nitro) showed superior binding modes free energies whereas compound 5j 4‐hydroxy) appropriate energy. These moieties hydrazone has shown 4‐fold increase interactions orientation. ADMET toxicity studies, 5e, 5m, , had potential be drugs have proven safe when using seven models. Further on checking selectivity other cholinesterase enzyme, came out selective towards AChE & acting another target as well. Finally, DFT analysis validated moreover Molecular Dynamic investigation revealed that is most capable candidate interact receptor comparing its molecular orbital energies, electrostatic maps, movement Ligand.

Language: Английский

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Transfer Hydrogenation of Azoarenes to Hydrazoarenes by Ammonia Borane Complex Catalyzed by Au Nanoparticles

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(17), P. 2982 - 2987

Published: July 27, 2023

Abstract Minute amounts of supported Au nanoparticles on TiO 2 (0.1 mol%) catalyze quantitatively at room temperature the transfer hydrogenation azoarenes to hydrazoarenes by ammonia borane complex, in ethanol as solvent. At 1 mol% catalyst loading level and 2.5 molar equivalents process occurs instantaneously. The is recyclable reusable. In absence reducing agent, undergo smooth Au/TiO ‐catalyzed aerobic oxidation back azoarenes.

Language: Английский

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Photo- and Electro-chemical Strategies for Indazole Synthesis

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100116 - 100116

Published: Dec. 1, 2024

The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential medicinal chemistry and drug discovery, which therefore has attracted sustained attention from synthetic community. Over recent decades, significant progress been achieved both organic photocatalysis electrosynthesis, offering novel approaches for efficient sustainable synthesis various functionalized indazoles. This mini-review highlights emerging methodological advancements photo-/electro-chemical two common forms indazole, namely 1H- 2H-indazoles, are classified by specific intramolecular bond formation patterns: (1) C-C formation, (2) C-N (3) N-N formation. reaction conditions, representative scopes, mechanistic understandings these protocols emphasized, to elucidate advantages limitations current strategies, with an aim inspire future innovations that may address challenges modern synthesis.Graphical abstractTo create your abstract, type over instructions template box below. Fonts or abstract dimensions should not be changed altered.

Language: Английский

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Recent Developments and Challenges in the Enzymatic Formation of Nitrogen–Nitrogen Bonds

ACS Catalysis, Journal Year: 2024, Volume and Issue: 15(1), P. 310 - 342

Published: Dec. 17, 2024

The biological formation of nitrogen–nitrogen (N–N) bonds represents intriguing reactions that have attracted much attention in the past decade. This interest has led to an increasing number N–N bond-containing natural products (NPs) and related enzymes catalyze their (referred this review as NNzymes) being elucidated studied greater detail. While more detailed information on biosynthesis NPs, which only become available recent years, provides unprecedented source biosynthetic enzymes, potential for biocatalytic applications been minimally explored. With review, we aim not provide a comprehensive overview both characterized NNzymes hypothetical biocatalysts with putative bond forming activity, but also highlight from perspective. We present compare conventional synthetic approaches linear cyclic hydrazines, hydrazides, diazo- nitroso-groups, triazenes, triazoles allow comparison enzymatic routes via these functional groups. Moreover, pathways well diversity reaction mechanisms are presented according direct groups currently accessible enzymes.

Language: Английский

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Azide-free cyclization reaction access to 4-aryl-NH-1,2,3-triazoles: P-toluenesulfonyl hydrazide and sulfamic acid as nitrogen sources

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 22(3), P. 482 - 485

Published: Dec. 13, 2023

An iodine-mediated cyclization has been developed to 4-aryl-

Language: Английский

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