Tailoring Nanomaterial Cross-Linkers through Lanthanide–Ligand Pairs: Guidance for Fine-Tuning the Structures and Properties of Luminescent Nanocomposite Hydrogels

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Integrating luminescent nanomaterials into hydrogels provides unique optical properties and improves their mechanical features for various applications. It is challenging but highly desirable to develop a versatile nanocomposite hydrogel system with tunable structures expand the potential uses of materials. Here, multiple amine-functionalized lanthanide-containing hydroxyapatites are synthesized as tailored nanomaterial cross-linkers interact polydextran aldehyde through imine bonds. The microstructure, gelation time, luminescence, rheological behavior, properties, thermal stability, degradation, swelling capability systematically investigated. This study reveals that strong binding affinity between surface metal ions capping ligands contributes densest network highest hydrogels. In addition, these possess dynamic self-healing, shear-thinning, injectability, improving suitability advanced lyophilized also demonstrated in differentiation volatile organic compounds. Taken together, adjustable microstructures characteristics this highlight its offering guidance producing diverse materials definable performances across fields.

Language: Английский

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In-depth review of synthesis of hydroxyapatite biomaterials from natural resources and chemical regents for biomedical applications

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106010 - 106010

Published: Oct. 16, 2024

Language: Английский

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ROS-Responsive Hydrogel for Bone Regeneration: Controlled Dimethyl Fumarate Release to Reduce Inflammation and Enhance Osteogenesis

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Large bone defects, often arising from trauma or infection, pose a considerable therapeutic challenge due to their limited capacity for spontaneous healing, thus requiring graft materials effective reparative procedures. The persistence of inflammation and elevated levels reactive oxygen species (ROS) within these defect sites significantly impede regeneration process. Addressing this, an injectable hydrogel system with ROS-responsive functionality is developed, specifically tailored the high ROS microenvironment characteristic defects. This incorporates hyaluronic acid functionalized dopamine introduce catechol moieties, employs 4-formylphenylboronic as crosslinking agent form dynamic matrix (HAC) carboxymethyl chitosan. HAC serves carrier dimethyl fumarate (DMF), compound established anti-inflammatory antioxidant effects, enabling its controlled release in response levels. Herein, we investigated physicochemical properties DMF loaded (DHAC) by microstructure observation, vitro degradation assay, self-healing test, injectability experiments, drug assay. Meanwhile, systematically effects on inflammation, intracellular ROS, osteogenesis. Consequently, DHAC reduced pro-inflammatory cytokines secreted RAW264.7 cells scavenged MC3T3 cells. effect was accompanied augmentation osteogenic potential promotion repair cranial defects rats. DHAC, which exhibits anti-inflammatory, antioxidant, activity, hold great strategy management large STATEMENT OF SIGNIFICANCE: Here, novel fumarate-loaded developed treatment Our findings demonstrated that not only promotes but also controls addressing two critical challenges healing. Comprehensive evaluations show significant improvements formation reduction animal models. Additionally, excellent scavenging ability, effectively modulating oxidative stress microenvironment. Findings suggest may serve promising clinical critical-sized

Language: Английский

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Cranial repair-promoting effect of oxidised sodium alginate/amino gelatine injectable hydrogel loaded with deer antler blood peptides

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141116 - 141116

Published: Feb. 15, 2025

Language: Английский

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Recent Advances in the Development and Application of Cell-Loaded Collagen Scaffolds

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4009 - 4009

Published: April 24, 2025

Tissue engineering techniques aim to improve or replace biological tissues organs by utilizing the extracellular matrix facilitate repair of damaged organs. Collagen-based scaffolds offer numerous advantages, including excellent biocompatibility, low immunogenicity, biodegradability, hemostatic properties, and mechanical strength. Collagen can reconstruct microenvironment, promote cell adhesion, migration, proliferation, differentiation, play a critical role in cell-to-cell cell-to-matrix interactions. has been extensively utilized tissue organ reconstruction. This review examines properties collagen, its composition, structure, characteristics, regulating various cellular behaviors. Additionally, preparation cell-loaded collagen is discussed, along with comprehensive overview their applications tissues, skin, nerve, bone/cartilage, heart, liver, others. Emerging strategies future perspectives for clinical are also presented. provides synthesis mechanisms underlying use as advanced biomaterials, emphasizing potential expand collagen.

Language: Английский

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A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138323 - 138323

Published: Dec. 1, 2024

Language: Английский

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Advancing Dentistry through Bioprinting: Personalization of Oral Tissues

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 530 - 530

Published: Oct. 20, 2023

Despite significant advancements in dental tissue restoration and the use of prostheses for addressing tooth loss, prevailing clinical approaches remain somewhat inadequate replicating native characteristics. The emergence three-dimensional (3D) bioprinting offers a promising innovation within fields regenerative medicine engineering. This technology notable precision efficiency, thereby introducing fresh avenue regeneration. Unlike traditional framework encompassing scaffolds, cells, signaling factors, 3D constitutes contemporary addition to arsenal engineering tools. ongoing shift from conventional dentistry more personalized paradigm, principally under guidance bioprinting, is poised exert influence foreseeable future. systematic review undertakes task aggregating analyzing insights related application context dentistry. Adhering PRISMA guidelines, an exhaustive literature survey spanning years 2019 2023 was performed across prominent databases including PubMed, Scopus, Google Scholar, ScienceDirect. landscape has ushered novel prospects dentoalveolar treatments interventions. expounds on accomplishments avenues regeneration pulp—dentin, bone, periodontal tissues, gingival tissues. progressive strides achieved realm hold potential not only enhance quality life but also catalyze transformative shifts domains medical practices.

Language: Английский

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Design of a double-layered material as a long-acting moisturizing hydrogel–elastomer and its application in the field protection of elephant ivories excavated from the Sanxingdui Ruins

RSC Advances, Journal Year: 2024, Volume and Issue: 14(34), P. 24845 - 24855

Published: Jan. 1, 2024

Hydrogel-elastomer possess long-term moisture retention and superior mechanical properties. It offers a transparent, flexible, strong alternative for effective protection of wet cultural relics like unearthed ivory.

Language: Английский

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Latest progress of self-healing hydrogels in cardiac tissue engineering

Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(3)

Published: Aug. 16, 2024

Language: Английский

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Advances in Injectable Polymeric Biomaterials and Their Contemporary Medical Practices

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Injectable biomaterials have been engineered to operate within the human body, offering versatile solutions for minimally invasive therapies and meeting several stringent requirements such as biocompatibility, biodegradability, low viscosity ease of injection, mechanical strength, rapid gelation postinjection, controlled release therapeutic agents, hydrophobicity/hydrophilicity balance, stability under physiological conditions, ability be sterilized. Their adaptability performance in diverse clinical settings make them invaluable modern medical treatments. This article reviews recent advancements design, synthesis, characterization injectable polymeric biomaterials, providing insights into their emerging applications. We discuss a broad spectrum these materials, including natural, synthetic, hybrid, composite types, that are being applied targeted drug delivery, cell protein transport, regenerative medicine, tissue adhesives, implants, bioimaging, diagnostics, 3D bioprinting. Ultimately, review highlights critical role shaping future treatments improving patient outcomes across wide range diagnostic

Language: Английский

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