RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
15(1), P. 10 - 54
Published: Oct. 20, 2023
Many
researchers
around
the
world
are
working
on
development
of
novel
anticancer
drugs
with
different
mechanisms
action.
In
this
case,
coumarin
is
a
highly
promising
pharmacophore
for
drugs.
Besides,
hybridization
moiety
other
pharmacophores
has
emerged
as
potent
breakthrough
in
treatment
cancer
to
decrease
its
side
effects
and
increase
efficiency.
This
review
aims
provide
comprehensive
overview
recent
derivatives
their
application
Herein,
we
highlight
describe
largest
number
research
works
reported
field
from
2015
August
2023,
along
action
structure-activity
relationship
studies,
making
articles
published
topic
date.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(8), P. 5547 - 5565
Published: Jan. 1, 2024
Spiro
heterocycle
frameworks
are
a
class
of
organic
compounds
that
possesses
unique
structural
features
making
them
highly
sought-after
targets
in
drug
discovery
due
to
their
diverse
biological
and
pharmacological
activities.
ChemistryOpen,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Heterocycles
are
a
vital
class
of
compounds
in
numerous
fields,
including
drug
discovery,
agriculture,
and
materials
science.
Efficient
methods
for
the
synthesis
heterocycles
remain
critical
meeting
demands
these
industries.
Recent
advances
multicomponent
reactions
(MCRs)
utilizing
2‐aminobenzothiazole
(ABT)
have
shown
promising
results
formation
heterocycles.
The
versatility
this
context
has
enabled
rapid
efficient
construction
diverse
heterocyclic
structures.
Various
synthetic
methodologies
involving
discussed,
highlighting
its
importance
as
valuable
building
block
complex
potential
applications
discovery
material
science
also
explored.
Overall,
review
provides
comprehensive
overview
current
state
research
field
offers
insights
into
future
directions
area
study.
We
highlight
ABT
versatile
sustainable
starting
via
MCRs,
with
significant
implications
chemical
industry.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(30)
Published: Aug. 6, 2024
Abstract
This
review
provides
an
overview
of
the
recent
advances
in
synthesis
diverse
heterocyclic
compounds
using
thiosemicarbazide
as
a
key
building
block
via
multicomponent
reactions.
Thiosemicarbazide
is
versatile
reagent
that
has
gained
significant
attention
organic
due
to
its
ability
participate
reactions
for
efficient
and
sustainable
construction
assembly
novel
bioactive
molecules
pharmaceuticals.
discusses
potential
applications
future
directions
this
rapidly
evolving
area
research.
It
valuable
insights
into
innovative
approaches
heterocycles
thiosemicarbazide,
showcasing
significance
modern
chemistry
In
summary,
current
state
art,
highlighting
use
reported
between
2015
early
2024.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3928 - 3953
Published: Jan. 1, 2025
This
review
studies
magnetically
recoverable
catalysts
designed
for
the
efficient
multicomponent
synthesis
of
organosulfur
compounds.
These
enhance
process
by
combining
efficiency
with
environmental
sustainability.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(4), P. 2334 - 2346
Published: Jan. 1, 2025
Benzo-fused
γ-lactams
are
fundamental
in
medicinal
chemistry,
acting
as
essential
elements
for
various
therapeutic
agents
due
to
their
structural
adaptability
and
capability
enhance
biological
activity.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 3, 2025
In
the
last
10
years,
synthesis
of
anthracene
scaffolds
has
attracted
considerable
interest
because
their
distinctive
electronic
characteristics
and
various
uses
in
organic
electronics,
photovoltaics,
therapeutics.
Anthracene,
a
polycyclic
aromatic
hydrocarbon,
is
valued
for
its
lightweight,
stability,
electron
transport
capabilities,
making
it
key
building
block
advanced
materials.
Traditional
methods
often
face
challenges
such
as
low
selectivity
harsh
conditions.
However,
recent
advancements
transition
metal-catalyzed
reactions
have
transformed
field,
offering
more
efficient
versatile
approaches.
This
review
examines
methodologies
utilizing
metal
catalysts
like
palladium,
zinc,
indium,
cobalt,
gold,
iridium,
rhodium
ruthenium,
which
enabled
novel
synthetic
pathways
selective
formation
substituted
anthracenes
through
cross-coupling
reactions.
The
function
ligands,
including
phosphines
N-heterocyclic
carbenes,
improving
reaction
efficiency
also
examined.
shift
towards
greener
noted,
with
focus
on
minimizing
waste
reducing
toxic
reagents.
Several
case
studies
demonstrate
successful
application
these
techniques,
highlighting
structural
diversity
functional
potential
derivatives
applications.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(8)
Published: July 20, 2023
Abstract
In
terms
of
pharmaceuticals
and
biological
applications,
synthesis
complex
organic
molecules
is
a
significant
fast‐developing
area.
this
context,
electrosynthesis
an
alternative
way
to
the
traditional
methods
for
chemo‐,
regio‐,
stereoselective
syntheses.
Electro‐organic
reactions
occur
at
room
temperature
normal
pressure,
through
transferring
electrons.
It
has
been
found
that
mild
approach
preparing
electrophilic
substrates,
bases,
nucleophiles
in
situ
,
from
highly
stable
low‐level
reagents;
which
can
be
further
applied
make
heterocycles
more
accessible.
While
several
promising
exist,
multi‐component
(MCRs)
have
drawn
much
attention
both
academia
industry
worldwide,
since
they
are
cost‐efficient
environmentally
friendly.
Combining
MCRs
produced
great
strategy
field
research.
This
review
focuses
on
recent
advances
electrochemical
heterocyclic
compounds
via
reactions,
reported
between
2015
March
2023.
