Naphthyridine-Based Electron Push–Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media DOI
Tomohiro Umeno,

Lisa Muroi,

Y. KAYAMA

et al.

Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(8), P. 1439 - 1446

Published: Aug. 4, 2023

In bioengineering, fluorescent amine-reactive probes are invaluable for the detection of amine species. particular, targeting lysine, which has a free amino group in acids, valid method protein detection. For this purpose, many "turn-on type" with reactivity have been developed; however, they require improvements. typical florescence probes, BODIPY and NBD analogs small Stokes shifts based on absorption emission lability an aqueous environment, respectively. study, new class 1,8-Nap-F, electron push–pull-type 1,8-naphthyridine framework, was designed investigated as probe. Generally, fluorophores exhibit large shift at expense enhancement media; thus, there is trade-off between possessing intense emission. However, 1,8-Nap-F reacts primary amines, yielding emissive products (>70 nm) without fluorescence quenching side products, even thereby overcoming disadvantages conditions. By applying specific features we achieved selective lysine bioimaging, such endoplasmic reticulum-selective labeling organelle staining, living cells by utilizing amine-substituted derivatives.

Language: Английский

Tryptophan-specific modification and diversification of peptides and proteins DOI
S K Kundu, A. Bandyopadhyay, Rajib Sarkar

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review provides an account of the tryptophan-specific conjugation peptides and proteins its extensive application in imaging living cells, radiolabelling proteins, protein engineering, etc .

Language: Английский

Citations

2
Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies DOI Creative Commons
Marco Bertolini, Man Sing Wong, Lorena Mendive‐Tapia

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5352 - 5372

Published: Jan. 1, 2023

T cells are an essential component of the immune system and display multiple biological functions. Smart probes range from small fluorophores to nanoconstructs, can target metabolic enzymatic biomarkers as well cell-surface receptors.

Language: Английский

Citations

24
Manganese(i)-catalyzed nucleophilic addition of C(sp3)–H bonds to aldehydes DOI
Hongxin Liu,

Tingyu Tang,

Bin Li

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(38), P. 5066 - 5069

Published: Jan. 1, 2024

Manganese( i )-catalyzed direct nucleophilic addition reaction of C(sp 3 )–H bonds to aromatic aldehydes has been developed. This is the first example manganese( bond activation.

Language: Английский

Citations

3
Hydrothermal synthesis of ZnGa2O4 nanophosphors with high internal quantum efficiency for near-infrared pc-LEDs DOI

Chengping Fang,

Shuaida Wang,

Shuai Wei

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(14), P. 6377 - 6385

Published: Jan. 1, 2024

ZnGa 2 O 4 : x Cr 3+ , y Ni 2+ nanophosphors exhibiting excellent luminescence performance in the second near-infrared region via an energy transfer process and phosphor-conversion LED (NIR pc-LED) application for infrared imaging.

Language: Английский

Citations

2
Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(i)-catalyzed C–H alkenylation DOI Creative Commons

Adelina Kopp,

Tsuyoshi Oyama, Lutz Ackermann

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(41), P. 5423 - 5426

Published: Jan. 1, 2024

The late-stage fluorescent labeling of structurally complex peptides bears immense potential for molecular imaging.

Language: Английский

Citations

2
Recent Advances and Prospects in Manganese‐Catalyzed C‐H Activation DOI Open Access

Gopan Anusree,

P. Devi, Gopinathan Anilkumar

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(19), P. 3963 - 3999

Published: Aug. 6, 2024

Abstract C−H activation represents an interesting alternative to conventional cross‐coupling methods, avoiding the requirement of additional steps introduce activating groups. Generally, Pd‐catalyzed reactions have been extensively employed for activation. The high cost and limited availability resources Pd prompted us explore transition metals. In this context, researchers are turning Earth Abundant Metals (EAMs) like manganese iron their potential in Significant progress has made manganese‐catalysed recent years, showcasing excellent specificity, environmental compatibility, versatility across different substrates. This review summarises approximately 50 publications highlighting significant advancements field from 2020 2023.

Language: Английский

Citations

1
The effect of rigidity on the emission of quadrupolar strongly polarized dyes DOI Creative Commons
B. Szymański, Smruti Ranjan Sahoo, Rashid R. Valiev

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(6), P. 2416 - 2420

Published: Jan. 1, 2024

Planarization of the pyrrolopyrrole chromophore switches mechanism non-radiative deactivation from intersystem crossing to internal conversion.

Language: Английский

Citations

1
Manganese-Catalyzed Z-Selective Allylation of Indoles with Allenyl Derivatives DOI

Doppalapudi Vineet Kumar,

Basker Sundararaju

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(14), P. 10087 - 10092

Published: July 10, 2024

Herein, we report a manganese-catalyzed

Language: Английский

Citations

1
Shedding a new light on quadrupolar 1,4-dihydropyrrolo[3,2-b]pyrroles: impact of electron-deficient scaffolds over emission DOI Creative Commons
B. Szymański, Smruti Ranjan Sahoo, Olena Vakuliuk

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

In this work, we disclose a series of seven quadrupolar centrosymmetric 1,4-dihydropyrrolo[3,2-

Language: Английский

Citations

0
Naphthyridine-Based Electron Push–Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media DOI
Tomohiro Umeno,

Lisa Muroi,

Y. KAYAMA

et al.

Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(8), P. 1439 - 1446

Published: Aug. 4, 2023

In bioengineering, fluorescent amine-reactive probes are invaluable for the detection of amine species. particular, targeting lysine, which has a free amino group in acids, valid method protein detection. For this purpose, many "turn-on type" with reactivity have been developed; however, they require improvements. typical florescence probes, BODIPY and NBD analogs small Stokes shifts based on absorption emission lability an aqueous environment, respectively. study, new class 1,8-Nap-F, electron push–pull-type 1,8-naphthyridine framework, was designed investigated as probe. Generally, fluorophores exhibit large shift at expense enhancement media; thus, there is trade-off between possessing intense emission. However, 1,8-Nap-F reacts primary amines, yielding emissive products (>70 nm) without fluorescence quenching side products, even thereby overcoming disadvantages conditions. By applying specific features we achieved selective lysine bioimaging, such endoplasmic reticulum-selective labeling organelle staining, living cells by utilizing amine-substituted derivatives.

Language: Английский

Citations

1