Analytical Artifact Due to Residual HCN in Acetonitrile: Identification and Control Strategies DOI
Vasantha Krishna Kadambar, Bhoopendra Singh Kushwah,

R K Gupta

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(11), P. 4059 - 4068

Published: Oct. 14, 2024

Mismatch in the potency from quantitative 1H NMR (∼96%) and calculated (∼94%) of an aldehyde intermediate led to investigation unknown impurity peak observed chromatography. The HR-MS/MS analysis suggested it be cyanohydrin derivative corresponding with addition ∼27 amu. Further was performed using analogous 3-methyl iso-nicotinaldehyde as a model compound. A postcolumn hydrogen deuterium exchange (H/D exchange) experiment further supported proposed structure cyanohydrin. source HCN for possible generation this traced certain brands acetonitrile used duirng analysis, where presence contaminant confirmed quantified ion aforementioned compound investigate effect other parameters like diluent composition, sample temperature storage time, pH diluent, duration sonication, which impact formation such artifact impurity. Based on results all experiments, mitigation strategies were avoid/control these impurities during analytical processing use methanol or HCN-free reduced composition freshly prepared solutions injections avoid longer time specially when sensitive substrates aldehydes ketones are analyzed. To evaluate if is limited interest common similar compounds, various involving ketone functional groups analyzed under conditions. indicated that more reactive than ketones, specifically containing heterocyclic ring pyridine prone generate

Language: Английский

Alkyl side-chain engineering to induce distinct microphase separation in random poly(phenylene piperidinium) ionomers for anion-exchange membrane fuel cells DOI
Qi Lei,

Chao Ge,

Na Li

et al.

Journal of Membrane Science, Journal Year: 2025, Volume and Issue: unknown, P. 123743 - 123743

Published: Jan. 1, 2025

Language: Английский

Citations

2
Visible-light induced direct C(sp3)–H functionalization: recent advances and future prospects DOI
Jia‐Lin Tu, Yining Zhu, Pengcheng Li

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5278 - 5305

Published: Jan. 1, 2024

This review summarizes the latest methodological advances in photocatalytic C(sp 3 )–H functionalization, with a particular emphasis on formation of C–P, C–B, C–S bonds, etc ., and some prominent efforts asymmetric C–H functionalization.

Language: Английский

Citations

16
Titanium in photocatalytic organic transformations: current applications and future developments DOI
Jia‐Lin Tu, Binbin Huang

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(33), P. 6650 - 6664

Published: Jan. 1, 2024

Titanium, as an important transition metal, has garnered extensive attention in both industry and academia due to its excellent mechanical properties, corrosion resistance, unique reactivity organic synthesis. In the field of photocatalysis, titanium-based compounds such titanium dioxide (TiO

Language: Английский

Citations

6
Theoretical exploration of fullerene-based X-Y@C80 (X = in, Sb, Te) nanomaterials as sensors for Thioguanine DOI
Idongesit J. Mbonu,

Peter O. Ajala,

Chidiogo Rita Okonkwo

et al.

Diamond and Related Materials, Journal Year: 2025, Volume and Issue: unknown, P. 112012 - 112012

Published: Feb. 1, 2025

Language: Английский

Citations

0
An Ambiphilic Phosphide with Three Different Coordination Modes to Group 7–10 Metals DOI
Adrien T. Normand, Hélène Cattey,

Marie‐José Penouilh

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Phosphide anions PX2- with electron-withdrawing substituents display ambiphilic properties. The use of P(V) thiophosphorane enables the coordination resulting bis(thiophosphoranyl)phosphide anion (BTPP = L) to a variety transition metals from groups 7 10. A series homoleptic and heteroleptic complexes was synthesized X-ray diffraction analysis revealed that, depending on metal, L may adopt three modes (κ3-(S, P, S); κ2-(S, P)) supporting distinct geometries (octahedral; tetrahedral; square planar). Complex L2Co displays Single Molecule Magnet (SMM) properties, complex LRh(COD) (COD 1,5-cyclooctadiene) catalyzes hydrosilylation terminal alkynes.

Language: Английский

Citations

0
Origin of the Felkin–Anh(–Eisenstein) model: a quantitative rationalization of a seminal concept DOI Creative Commons
Daniel González‐Pinardo, F. Matthias Bickelhaupt, Israel Fernández

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12380 - 12387

Published: Jan. 1, 2024

The origin of the widely used Felkin–Anh(–Eisentein) model is quantitatively analyzed in detail by means state-of-the-art computational methods.

Language: Английский

Citations

2
Analytical Artifact Due to Residual HCN in Acetonitrile: Identification and Control Strategies DOI
Vasantha Krishna Kadambar, Bhoopendra Singh Kushwah,

R K Gupta

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(11), P. 4059 - 4068

Published: Oct. 14, 2024

Mismatch in the potency from quantitative 1H NMR (∼96%) and calculated (∼94%) of an aldehyde intermediate led to investigation unknown impurity peak observed chromatography. The HR-MS/MS analysis suggested it be cyanohydrin derivative corresponding with addition ∼27 amu. Further was performed using analogous 3-methyl iso-nicotinaldehyde as a model compound. A postcolumn hydrogen deuterium exchange (H/D exchange) experiment further supported proposed structure cyanohydrin. source HCN for possible generation this traced certain brands acetonitrile used duirng analysis, where presence contaminant confirmed quantified ion aforementioned compound investigate effect other parameters like diluent composition, sample temperature storage time, pH diluent, duration sonication, which impact formation such artifact impurity. Based on results all experiments, mitigation strategies were avoid/control these impurities during analytical processing use methanol or HCN-free reduced composition freshly prepared solutions injections avoid longer time specially when sensitive substrates aldehydes ketones are analyzed. To evaluate if is limited interest common similar compounds, various involving ketone functional groups analyzed under conditions. indicated that more reactive than ketones, specifically containing heterocyclic ring pyridine prone generate

Language: Английский

Citations

0