Frontiers in Lab on a Chip Technologies,
Journal Year:
2024,
Volume and Issue:
3
Published: April 30, 2024
For
patients
with
end
stage
organ
failure,
transplant
is
frequently
the
only
curative
option
available.
However,
organs
available
for
are
in
critically
short
supply
around
world,
which
has
led
to
lengthy
wait
times
and
increased
mortality.
Increased
global
life
expectancy,
coupled
raised
age
thresholds
recipients,
heightened
demand
further
compounded
need
alternative
strategies.
Bioengineering
substitutes
including
organ-on-a-chip
3D
bioprinting
technologies
have
made
considerable
strides
toward
whole
generation.
Skin
where
most
advances
been
thus
far,
due
relatively
less
complex
spatial
architecture
industry
interest
development
of
sophisticated
models
pharmaceutical
cosmetics
testing.
Here,
we
discuss
challenges
recapitulating
complexity
native
skin,
a
stratified
structure,
vascularization,
inclusion
skin
appendages,
such
as
hair
follicles
sweat
glands.
We
current
technological
biological
progress
field
tissue
bioengineering
well
highlight
future
generate
de
novo
grafting.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(20), P. 9346 - 9346
Published: Oct. 14, 2024
Biotechnological
processes
are
essential
for
developing
economies
that
aim
to
stand
out
in
future
markets.
The
use
of
bioreactors
is
one
the
most
important
unit
operations
biotechnological
processes,
and
real-time
monitoring
ensure
precise
bioprocess
control.
This
review
presents
different
types
bioreactors,
sensors,
applications
other
sectors.
Bioreactors,
controlled
systems
cultivating
microorganisms
cells,
tools
various
fields,
from
scientific
research
industrial
production.
a
variety
sensors
critical
accurate,
monitoring,
early
problem
detection,
reproducibility,
cost
reduction,
increased
efficiency.
These
benefits
being
realized
numerous
applications,
including
biofuel
production,
bioremediation
leaching
tissue
engineering,
drug
manufacturing.
Innovations
bioreactor
technology
expanding
opportunities
more
sustainable
healthier
future.
By
new
integrating
advanced
exploring
promising
playing
key
role
addressing
global
challenges
sustainably
advancing
science
technology.
Virtual and Physical Prototyping,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 5, 2024
Organ
transplantation
is
the
optimal
treatment
for
patients
with
end-stage
organ
failure,
but
which
faces
challenge
of
donor
shortage.
Two-dimensional
cell
culture
and
animal
experiments
are
difficult
to
completely
simulate
complex
cellular
microenvironment
drug
testing.
Three-dimensional
(3D)
bioprinting
an
emerging
manufacturing
technology
fabricate
artificial
tissues
organs
screening.
This
review
first
describes
technologies
used
constructs,
including
jetting-based,
extrusion-based,
vat
photopolymerization-based
methods
other
3D
approaches.
The
various
kinds
bioinks,
sources,
most
recent
applications
in
testing
subsequently
summarized.
Finally,
we
discuss
challenges
prospects
organs.
aims
facilitate
overcoming
obstacles
identified
on
challenging
journey
towards
adoption
tissue
MedComm,
Journal Year:
2024,
Volume and Issue:
5(10)
Published: Sept. 23, 2024
Bioprinting
is
a
highly
promising
application
area
of
additive
manufacturing
technology
that
has
been
widely
used
in
various
fields,
including
tissue
engineering,
drug
screening,
organ
regeneration,
and
biosensing.
Its
primary
goal
to
produce
biomedical
products
such
as
artificial
implant
scaffolds,
tissues
organs,
medical
assistive
devices
through
software-layered
discrete
numerical
control
molding.
Despite
its
immense
potential,
bioprinting
still
faces
several
challenges.
It
requires
concerted
efforts
from
researchers,
engineers,
regulatory
bodies,
industry
stakeholders
are
principal
overcome
these
challenges
unlock
the
full
potential
bioprinting.
This
review
systematically
discusses
principles,
applications,
future
perspectives
while
also
providing
topical
overview
research
progress
over
past
two
decades.
The
most
recent
advancements
comprehensively
reviewed
here.
First,
printing
techniques
methods
summarized
along
with
related
bioinks
supporting
structures.
Second,
interesting
representative
cases
regarding
applications
biosensing
introduced
detail.
Finally,
remaining
suggestions
for
directions
proposed
discussed.
one
areas
fields.
aims
devices.
perspectives,
which
provides
description
Medical Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Current
two-dimensional
(2D)
cell
models
for
effective
drug
screening
suffer
from
significant
limitations
imposed
by
the
lack
of
realism
in
physiological
environment.
Three-dimensional
(3D)
organoids
hold
immense
potential
mimicking
key
functions
human
organs
overcoming
traditional
2D
models.
However,
current
techniques
preparation
3D
had
reproducibility,
scalability,
and
ability
to
closely
replicate
complex
microenvironment
found
vivo
.
Additionally,
culture
systems
often
involve
lengthy
labor-intensive
processes
that
hinder
high-throughput
applications
necessary
a
large-scale
screening.
Advancements
bioprinting
technologies
offer
promising
solutions
these
challenges
enabling
precise
spatial
control
over
placement
material
composition,
thereby
facilitating
creation
more
physiologically
relevant
than
techniques.
This
review
provides
comprehensive
summary
recent
advances
creating
models,
which
begins
with
an
introduction
different
types
(especially
focus
on
volumetric
(VBP)
technique),
followed
overview
bioinks
utilized
bioprinting.
Moreover,
we
also
introduce
disease
efficiency
evaluation
regenerative
medicine.
Finally,
possible
strategies
development
clinical
translation
are
concluded.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 21, 2025
Hair
follicles
are
essential
appendages
of
human
skin
that
function
in
protection,
sensation,
thermoregulation
and
social
interactions.
The
multicellular
components,
particularly
the
dermal
papilla,
matrix
bulge
housing
stem
cells,
enable
cyclic
hair
growth
postnatally.
However,
miniaturization
loss
can
occur
context
ageing,
trauma
various
alopecia-related
diseases.
Conventional
treatments
involve
redistribution
existing
follicles,
which
may
not
be
viable
patients
lacking
follicular
resources.
Recent
progress
comprehension
morphogenesis
development
biomaterials
has
significantly
advanced
follicle
reconstruction,
incorporating
organ
germ
assembling,
cell
induction
bioprinting
techniques.
Despite
these
advancements,
fully
restoring
remains
challenging
due
to
complexities
replicating
embryonic
signals
sustaining
cycles.
Identifying
suitable
sources
for
clinical
applications
also
presents
a
hurdle.
Here,
we
retrospect
made
field
regeneration,
aiming
offer
an
exhaustive
analysis
on
benefits
limitations
methods,
foster
innovative
solutions.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(4), P. 118 - 118
Published: March 28, 2025
Corneal
transplantation
remains
a
critical
treatment
option
for
individuals
with
corneal
disorders,
but
it
faces
challenges
such
as
rejection,
high
associated
medical
costs,
and
donor
scarcity.
A
promising
alternative
replacement
involves
fabricating
artificial
cornea
from
patient's
own
cells.
Our
study
aimed
to
leverage
bioprinting
develop
model
using
human
stromal
cells
embedded
in
collagen-based
bioink.
We
generated
both
cellular
acellular
collagen
I
(COL
I)
constructs.
Cellular
constructs
were
cultured
up
4
weeks,
gene
expression
analysis
was
performed
assess
extracellular
matrix
(ECM)
remodeling
fibrotic
markers.
results
demonstrated
significant
decrease
the
of
COL
I,
III
III),
vimentin
(VIM),
vinculin
(VCL),
indicating
dynamic
process
towards
more
physiologically
relevant
ECM.
Overall,
our
provides
foundational
framework
developing
customizable,
replacements
technology.
Further
research
is
necessary
optimize
bioink
composition
evaluate
functional
biomechanical
properties
these
bioengineered
corneas.
