ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(37)
Published: Sept. 30, 2024
Abstract
In
this
study,
the
synthesis
and
characterization
of
poly(ethyl
methacrylate‐
co
‐acrylamide)
(i.e.,
poly(EMA‐
‐AAm))
nanogels
loading
release
studies
doxorubicin
hydrochloride
were
carried
out.
The
was
out
using
emulsion
polymerization
technique
at
60
°C.
Swelling
experiments
showed
that
sensitive
to
temperature
pH
medium.
Zeta
sizer
analysis
results
synthesized
had
an
average
size
23.17
nm
PDI
value
0.270.
into
nanogels,
drug
capacity
(DLC)
nanogel
determined
as
32%
efficiency
(DLE)
77%.
Release
conducted
=
5.4
7.4
37
°C
percentage
17%
even
in
32
h
7.4,
82%
5
5.4.
different
temperatures
revealed
°C,
85%
39
89%
41
These
‐AAm)
can
be
used
targeted
controlled
increase
effects
while
reducing
side
effects.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13302 - 13302
Published: Dec. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 216 - 216
Published: March 20, 2025
The
hydrogel
patent
landscape
is
characterized
by
rapid
growth
and
diverse
applications,
particularly
in
the
biomedical
field.
Advances
material
science,
chemistry,
novel
manufacturing
techniques,
a
deeper
understanding
of
biological
systems
have
revolutionized
development
hydrogel-based
biomaterials.
These
innovations
led
to
enhanced
properties
expanded
regenerative
medicine,
drug
delivery,
tissue
engineering,
positioning
hydrogels
as
pivotal
future
engineering.
In
this
study,
an
updated
for
biomaterials
proposed.
By
analyzing
documents,
classifications,
jurisdictions,
applicants,
overview
provided
characterize
key
trends
insights.
analysis
reveals
that
hydrogel-related
patents
are
experiencing
significant
growth,
with
strong
focus
on
applications.
Foundational
research
formation
remains
dominant,
96,987
documents
highlighting
advancements
crosslinking
polysaccharide-based
materials,
biologically
active
wound
care
regeneration.
United
States
China
lead
filings,
notable
contributions
from
Europe
high
number
international
under
Patent
Cooperation
Treaty
(PCT)
system,
reflecting
global
interest
technologies.
Moreover,
emerging
include
biodegradable
designed
regeneration,
wearable
sensors,
advanced
therapeutic
applications
such
chemoembolization
agents
vascular
defect
treatments.
increasing
integration
bioactive
elements
driving
multifunctional
tailored
specific
medical
environmental
needs.
While
study
focuses
trends,
alignment
between
patenting
activities
underscores
role
bridging
scientific
discoveries
industrial
Future
could
explore
citation
impact
assessments
gain
insights
into
technological
significance
inventions.
Finally,
selection
top
10
recent
granted
field
presented
illustrative
example
innovation
area
illustrate
cutting-edge
innovations.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Polysaccharides,
the
most
abundant
biopolymers
in
nature,
have
attracted
attention
of
researchers
and
clinicians
due
to
its
practicality
biomedical
pharmaceutical
sciences.
These
biomaterials
high
bioavailability
play
structural
functional
roles
living
organisms.
Polysaccharides
are
classified
into
several
groups
based
on
their
origin,
including
plant
polysaccharides
marine
(like
chitosan,
hyaluronic
acid,
dextran,
alginates,
etc.)
with
specific
applications.
possess
unique
physicochemical
(such
as
surface
groups,
solubility,
stability),
mechanical
strength
tensile),
antioxidant
activity,
biocompatibility,
biodegradability,
renewability,
non-immunogenicity)
characteristics
which
made
them
excellent
platforms
for
a
wide
variety
Ease
extraction
different
preparation
approaches
mentioned
other
potential
properties
that
further
improved
They
drug/bioactive
encapsulation
capacity
sustained/controlled
release
manner
vivo
microenvironments.
The
anti-inflammatory
immunomodulation,
stimuli-responsive
release,
passive
active
delivery
considered
features
these
indicated
practical
applications
sciences,
biosensors,
tissue
engineering,
implantation,
wound
healing,
vascular
grafting,
vaccines.
This
review
highlights
advances
polysaccharide-based
materials
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(16), P. 4018 - 4028
Published: Jan. 1, 2024
A
gold
nanocluster-intercalated
zeolitic
imidazolate
framework-8
(AuNC@ZIF-8)
as
a
luminescent
nanocarrier
with
high
quantum
yield
(52.96%)
and
photolysis
property
is
synthesized
via
coordination
assembly
for
light-triggered
drug
release
in
cells.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7446 - 7458
Published: Oct. 16, 2024
An
intelligent
insulin
delivery
system
targeting
intestinal
absorption
and
glucose
responsiveness
can
enhance
the
bioavailability
through
oral
therapy,
offering
promising
diabetes
treatment.
In
this
paper,
a
pH
dual-response
polymer
hydrogel
using
carboxymethyl
agarose
modified
with
3-amino-phenylboronic
acid
l-valine
(CPL)
was
developed
as
an
carrier,
exhibiting
excellent
biocompatibility
effective
encapsulation.
The
encapsulated
in
(Ins-CPL)
released
controlled
manner
response
to
