Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility DOI Creative Commons
Denisse-Iulia Bostiog, N Simiónescu, Adina Coroabă

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Aug. 17, 2024

Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated using drug delivery systems, such as functionalized gold nanoparticles (AuNPs), known for their versatility unique properties. This study aimed to develop multi-shell AuNPs with MTX the improvement of antitumoral, antioxidant, biocompatibility features. Stable phosphine-coated were synthesized tailored polyethylene glycol (PEG) short-branched polyethyleneimine (PEI) moieties, followed covalent binding. Physicochemical characterization UV-vis Fourier-transform infrared spectroscopy (FTIR) spectroscopy, dynamic light scattering (DLS), scanning transmission electron microscopy (STEM), X-ray photoelectron (XPS) confirmed synthesis at each step. The antioxidant activity was determined DPPH radical scavenging assay, ferric ions' reducing power (FRAP), cupric capacity (CUPRAC) assays. Biocompatibility cytotoxicity assessed MTT LDH assays on HaCaT human keratinocytes CAL27 squamous cell carcinoma. demonstrated enhanced pronounced cytotoxic effect tumoral cells compared individual components, highlighting potential improving therapy.

Language: Английский

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications DOI Creative Commons
Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Language: Английский

Citations

13
Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications DOI

Bilal AbdulMajeed Mukhlif,

Muhammad Ikram Ullah, Subasini Uthirapathy

et al.

Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

2
Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices DOI
Qumber Abbas, Muhammad Zia‐ur‐Rehman, Habib Ullah

et al.

Journal of Cleaner Production, Journal Year: 2024, Volume and Issue: 471, P. 143454 - 143454

Published: Aug. 22, 2024

Language: Английский

Citations

4
Advances in phototheranostic agents: From imaging to targeted therapy DOI

M. Samadzadeh,

Arezoo Khosravi, Atefeh Zarepour

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102516 - 102516

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development of Chemical Tags for Universal Lipid Nanoparticle Visualization and Tracking in 2D and 3D Imaging DOI Creative Commons

Hannia V. Balcorta,

Mario Y. Mata Corral,

Ángel Gallegos

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Precise delivery of therapeutic agents to specific cells and subcellular compartments is crucial for effective disease treatment. Lipid nanoparticles (LNPs) are promising drugs gene nanocarriers, but understanding their transport within tissues remains limited. We developed SPARKLE (Strategic Peptide, Anchored, Retained, Kept after Elimination), a fluorescent peptide tag designed track LNPs with advanced optical imaging techniques that involve lipid disruption (e.g., cell permeabilization or tissue clearing). Unlike conventional lipophilic dyes wash out during disruption, tags retained fluorescently mark the positions LNPs. As proof concept, we demonstrated utility by tracking in vitro using painting assay vivo CLARITY clearing 3D light-sheet microscopy. can offer valuable insights into LNP behavior biological environments, enhancing targeting cargo release clinical translation.

Language: Английский

Citations

0
Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility DOI Creative Commons
Denisse-Iulia Bostiog, N Simiónescu, Adina Coroabă

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Aug. 17, 2024

Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated using drug delivery systems, such as functionalized gold nanoparticles (AuNPs), known for their versatility unique properties. This study aimed to develop multi-shell AuNPs with MTX the improvement of antitumoral, antioxidant, biocompatibility features. Stable phosphine-coated were synthesized tailored polyethylene glycol (PEG) short-branched polyethyleneimine (PEI) moieties, followed covalent binding. Physicochemical characterization UV-vis Fourier-transform infrared spectroscopy (FTIR) spectroscopy, dynamic light scattering (DLS), scanning transmission electron microscopy (STEM), X-ray photoelectron (XPS) confirmed synthesis at each step. The antioxidant activity was determined DPPH radical scavenging assay, ferric ions' reducing power (FRAP), cupric capacity (CUPRAC) assays. Biocompatibility cytotoxicity assessed MTT LDH assays on HaCaT human keratinocytes CAL27 squamous cell carcinoma. demonstrated enhanced pronounced cytotoxic effect tumoral cells compared individual components, highlighting potential improving therapy.

Language: Английский

Citations

2