Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
The
periodontal
tissue
comprises
alveolar
bone,
cementum,
and
ligament
(PDL),
forming
a
highly
hierarchical
architecture.
Although
current
therapies
could
regenerate
the
hard
well,
simultaneous
reconstruction
of
soft
remains
great
clinical
challenge
with
major
difficulty
in
orientated
PDL
regeneration.
Using
unidirectional
freeze‐casting
method
biomimetic
mineralization
technique,
we
construct
bilayer
scaffold
aligned
chitosan
ZIF‐8
resembling
PDL,
intrafibrillarly
mineralized
collagen
bone.
exhibits
different
geomorphic
clues
chemical
microenvironments
to
realize
perfect
simulation
natural
induce
fibrogenic
differentiation
bone
mesenchymal
stromal
cells
(BMSCs),
osteogenic
BMSCs.
simulate
complex
tissue,
exhibiting
promise
for
synchronized
multi‐tissue
regeneration
tissue.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(33), P. 8007 - 8032
Published: Jan. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
Gels,
Journal Year:
2024,
Volume and Issue:
10(8), P. 495 - 495
Published: July 26, 2024
Bacterial
infection
treatment
for
chronic
wounds
has
posed
a
major
medical
threat
and
challenge.
Bacteria
at
the
wounded
sites
can
compete
with
immune
system
subsequently
invade
live
tissues,
leading
to
more
severe
tissue
damage.
Therefore,
there
is
an
urgent
demand
wound
dressings
antibacterial
anti-inflammatory
properties.
Considering
concept
of
moist
healing,
hydrogels
three-dimensional
(3D)
network
structure
are
widely
used
as
due
their
excellent
hydrophilicity,
water
retention
properties,
biocompatibility.
Developing
infected
been
receiving
extensive
attention
recently.
This
article
categorizes
according
materials
modes,
introduces
recent
findings
progress
regarding
status.
More
importantly,
development
emerging
technologies,
new
therapies
utilized
prepare
such
nanoenzymes,
photothermal
therapy
(PTT),
photodynamic
(PDT),
metal–organic
frameworks
(MOFs),
other
external
stimuli-responsive
methods.
this
review
also
examines
progress,
challenges,
future
trends
dressings.
In
following
studies,
will
still
be
focus
on
that
have
high
performance,
multi-functions,
intelligence,
especially
biocompatibility,
long-lasting
property,
responsiveness,
on-demand
therapeutic
ability.
