Fe3O4@Bi2S3 Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism DOI
Xiaowei Song, Liang Xiao, Lingling Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.

Language: Английский

Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells DOI
Weinan Zhang,

Yechun Jiang,

Litao Liu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

Citations

3
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

7
Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease DOI Creative Commons

Wanyue Fu,

Zhongshi Huang, Weiqi Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

Citations

5
Cu2O-Based Core–Shell Nanostructures with Glutathione Depletion and O2 Generation Properties for Photodynamic/Chemodynamic Tumor Therapy DOI
Yuchao Zhu, Yelei Zhang,

Yilin Shen

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(2), P. 1284 - 1294

Published: Jan. 8, 2025

Hypoxia and high glutathione (GSH) contents in the tumor microenvironment (TME) diminish efficacy of single-modality photodynamic therapy (PDT) chemodynamic (CDT). Cu2O can effectively release Cu+ within TME, facilitating CDT, concurrently generate O2 to mitigate hypoxia. Co-delivery with photosensitizers (PSs) tumors could potentially enhance PDT/CDT combination therapy. However, challenges such as instability, susceptibility vivo substances affecting catalytic activity, toxicity normal tissues limit utility Cu2O. To overcome these limitations, we propose utilization core GSH-responsive metal–organic framework (MOF) shells, uniformly grown on its surface form Cu2O@MOFs heterostructures. This design prevents leakage deactivation core. We synthesized Cu2+-doped ZIF-67 multifunctional MOF shells situ subsequently incorporated photosensitizer ZnPc into MOFs create Cu2O@Cu2+/ZIF-67@ZnPc (CCZZ). Upon entry cells, this nanodrug degrades presence slight acidity an optimal GSH concentration, releasing while depleting GSH. The released degraded ZIF-67, respectively, Co2+ for CDT O2, consumes PDT under laser irradiation, achieving synergistic best our knowledge, is first study based synthesis Cu2O@Cu-MOFs that achieves dual-enhanced by simultaneously generating oxygen.

Language: Английский

Citations

0
Recent Advancements and Future Prospects of Asymmetrically Coordinated Single-Atom Nanozymes with High Enzymatic-like Activity for Biotherapy and Diagnosis: A Review DOI
Changli Chen,

Gangzhi Qin,

Xinyue Geng

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

Citations

0
Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis DOI Creative Commons

Zhaoyou Chu,

Zheng Wang,

Wanyue Fu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Recent investigations have underscored the significant role of manganese ions (Mn2+) in immunization, particularly through activation cGAS-STING pathway, which enhances antitumor immune responses. However, rapid metabolism free Mn2+ following administration limits its effectiveness as an adjuvant. To address these challenges, microneedles (MNs) hyaluronic acid containing Sparfloxacin (SP) and zinc-manganese sulfide (ZMS) are prepared for postoperative situ treatment triple-negative breast cancer (TNBC) to prevent recurrence combat wound infection. ZMS/SP (ZS)-loaded MNs exhibit strong antimicrobial antibiofilm properties that crucial preventing infections. Moreover, generation reactive oxygen species by disrupts oxidative balance, effectively activating immunogenic cell death facilitating release cytokines. ZS significantly suppressed tumor growth, reduced lung metastasis, promoted healing. These effects accompanied notable increases infiltration activation, is consistent with gene sequencing results. Activation pathway further improved immunity. findings highlight potential effective safe utilizes immunostimulatory enhance local systemic responses prevention TNBC metastasis.

Language: Английский

Citations

0
Magnetically and optically powered nanozymes: Boosting breast cancer therapy with magnetothermodynamic-enhanced ferroptosis and apoptosis DOI

Ruocan Liu,

Yundi Wu,

Huanran Qu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161353 - 161353

Published: March 1, 2025

Language: Английский

Citations

0
NIR light activates upconverting nanoparticles/ZnxMn1-xS core-shell nanoparticles for improved breast cancer treatment DOI
Guoqiang Zhang,

Yechun Jiang,

Weinan Zhang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

TUC@ZMS targets cancer cells, depletes GSH, and integrates PDT, CDT, H 2 S gas therapy to eliminate tumors induce ICD, while Mn 2+ activate cGAS-STING, eliciting systemic anti-tumor immunity, curbing tumor growth lung metastasis.

Language: Английский

Citations

0
Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags DOI Creative Commons

Yung-Ching Chang,

Chan‐Chuan Liu,

Wan-Ping Chan

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Glioblastoma (GBM) is an aggressive and fatal tumor. The infiltrative spread of GBM cells hinders gross total resection. residual are significantly associated with survival recurrence. Therefore, a theranostic method that can enhance the contrast between normal astrocyte (AS) selectively eradicate highly desired. In this report, both cultured in same microplate well to imitate coexistence environment treated Raman tags functionalized by anti-EGFR. Compared AS cells, show 25% higher emission, their cell death rate increases factor 2. These results demonstrate potential for selective eradication guided robust signals after primary surgery.

Language: Английский

Citations

0
Longitudinal Multi-Omics Analysis of the Gut-Liver Axis: Unraveling the Molecular Mechanisms of Metabolic Homeostasis Regulation by Pd@Pt Nanozymes DOI Creative Commons
Yanan Wang,

Nan Cheng,

Qí Zhāng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101685 - 101685

Published: March 19, 2025

Language: Английский

Citations

0