Published: Jan. 1, 2024
Language: Английский
Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 102, P. 101350 - 101350
Published: Feb. 10, 2025
Language: Английский
Citations
1
Small Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with 2020 Nobel Prize Chemistry, has garnered significant attention its precision editing genomes. However, CRISPR system faces challenges when applied vivo, including low delivery efficiency, off-target effects, instability. To address challenges, innovative technologies targeted precise have emerged. Engineered carrier platforms represent substantial advancement, improving stability, precision, reducing side effects associated editing. These facilitate efficient local systemic various tissues cells, immune cells. This review explores recent advances, benefits, CRISPR-based delivery. It examines carriers nanocarriers (polymeric, lipid-derived, metallic, bionanoparticles), viral particles, virus-like exosomes, providing insights into their clinical utility future prospects.
Language: Английский
Citations
5
Published: Jan. 1, 2024
Language: Английский
Citations
0