Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21668 - 21681

Published: Jan. 1, 2024

Novel phthalazine derivatives were designed, synthesized and evaluated against Hep G2 MCF-7 as VEGFR-2 inhibitors.

Language: Английский

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Rational design, docking, syntheses, ADMET and cytotoxicity assessments of iodoquinazoline derivatives as inhibitors of EGFRT790M and VEGFR-2

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141634 - 141634

Published: Jan. 1, 2025

Language: Английский

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Antibacterial and anti-tumor properties of marine posidonoia oceanica leaf extracts

Journal of Herbs Spices & Medicinal Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: March 17, 2025

Language: Английский

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Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers

RSC Advances, Journal Year: 2024, Volume and Issue: 14(37), P. 27110 - 27121

Published: Jan. 1, 2024

New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors were synthesized joined to different spacers including pyrazole, α,β-unsaturated ketonic fragment, pyrimidinone and/or pyrimidinthione.

Language: Английский

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Exploration of cytotoxicity of iodoquinazoline derivatives as inhibitors of both VEGFR‐2 and EGFR^T790M: Molecular docking, ADMET, design, and syntheses

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(11)

Published: Aug. 1, 2024

Novel inhibitors of epidermal growth factor receptor (EGFR)

Language: Английский

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