Biowaste Transformation to Functional Materials: Structural Properties, Extraction Methods, Applications, and Challenges of Silk Sericin

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(42)

Published: Nov. 1, 2024

Abstract This review underscores the novelty of silk sericin, often regarded as a byproduct in production. Comprising approximately 30% silk, sericin possesses valuable properties that have been largely overlooked favor fibroin. work focuses on innovative extraction methods to convert typically considered waste, into resource. By examining these techniques alongside diverse applications, aims enhance recognition and utilization research industry. Various processes where traditional methods, some new techniques, are all discussed. In detail, advantages, limitations, strategy optimization associated with each method highlighted. For instance, has shown promise wound treatment agent, scaffold for tissue engineering, carrier drug delivery, biomaterial regenerative medicine field biomedical science due its biocompatibility, biodegradability, nontoxicity. Additionally, it also finds application cosmetic industry, is used skincare products moisturizing, antioxidant, antiaging properties. Eventually, challenges, prospects intensively comprehensive expected serve growing body knowledge surrounding foster further development sericin‐related fields.

Language: Английский

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Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 114 - 114

Published: Feb. 6, 2025

Silk sericin (SS), a by-product of the textile industry, has gained significant attention for its biomedical potential due to biocompatibility and regenerative potential. However, literature lacks information on SS processing methods resulting physicochemical properties. This study represents first step in protocol optimization standardization. In present work, different techniques were studied compared extracted from boiling water: evaporation, rotary lyophilization, dialysis, which presented recovery yield approximately 27–32%. The goal was find most promising process concentrate solutions, ensure that structure highly preserved. As result, new cryo-lyophilization methodology proposed. proposed method allows preservation amorphous structure, offers advantages including complete dissolution water PBS, an increase storage stability, possibility scaling-up, making it suitable industrial applications. second part work focused addressing another challenge processing: efficient non-destructive sterilization. Supercritical CO2 (scCO2) been gaining momentum last years sterilizing sensitive biopolymers biological materials non-toxicity mild conditions. Thus, scCO2 technology validated as technique terminal sterilization SS. this way, possible engineer sequential cryo-lyophilization/scCO2 able preserve original properties natural silk protein. Overall, we have valorized into sterile, off-the-shelf, bioactive, water-soluble material, with be used biomedical, pharmaceutical, or cosmetic industries.

Language: Английский

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Native Silk Fibers: Protein Sequence and Structure Influences on Thermal and Mechanical Properties

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Silk fibers produced by arthropods have inspired an array of materials with applications in healthcare, medical devices, textiles, and sustainability. Silks exhibit biodiversity distinct variations primary protein constituent sequences (fibroins, spidroins) structures across taxonomic classifications, specifically the Lepidopteran Araneae orders. Leveraging arthropod silks offers advantages due to diverse mechanical properties thermal stabilities achievable, primarily attributed fiber crystallinity repeating amino acid motifs. In this review, we aim delineate known silk correlate them predicted secondary structures, informed newly annotated genomes. We will discuss established patterns repeat motifs governing specific underscore biological diversity within fibroin spidroin sequences. Elucidating relationship between natural identify strategies for designing new through rational silk-based design.

Language: Английский

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Recent advancements and challenges in 3D bioprinting for cancer applications

Bioprinting, Journal Year: 2024, Volume and Issue: 43, P. e00357 - e00357

Published: Sept. 13, 2024

Language: Английский

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Biogenic gold nanoparticles stabilized with silk sericin and their impacts on osteogenic induction and surface modification of polymethyl methacrylate

Applied Surface Science, Journal Year: 2024, Volume and Issue: unknown, P. 161591 - 161591

Published: Oct. 1, 2024

Language: Английский

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Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 296 - 310

Published: Dec. 16, 2024

Silk sericin (SS) has been widely discarded as a waste by the silk textile industry during degumming process to obtain fibroin. However, in past decade, an in-depth understanding of its properties and functions turned it into high added-value biomaterial for biomedical applications. Herein, we report molecular design development sustainable supramolecular multilayered nanobiomaterials encompassing SS oppositely charged chitosan (CHT) through combination self-assembly electrostatically driven layer-by-layer (LbL) assembly technology. The successful buildup SS/CHT was demonstrated quartz crystal microbalance with dissipation monitoring attenuated total reflectance-Fourier transform infrared spectroscopy, nanofilms' wettable nanofibrillar-like topography were shown water contact angle, atomic force microscopy, scanning electron microscopy. In vitro assays cytocompatibility LbL nanofilms toward human primary dermal fibroblasts, holding great promise biofunctional nanocoatings drug/therapeutics/cell delivery, tissue engineering, regenerative medicine.

Language: Английский

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