Bioinspired Ionic Elastomer with Skin‐Like Piezo‐Ionic Dynamics Enabled by a Self‐Confined Multi‐Interaction Network DOI

Zhiyue Fang,

Lei Wang,

Cuiyuan Liang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Soft ionic elastomers have attracted considerable research interest in mimicking the multiple functions of human skin. However, these struggle to simultaneously achieve controllable ion dynamics and other essential performance, such as self‐healing ability appropriate mechanical robustness. Herein, bioinspired by Piezo proteins integrins skin, thioctic acid (TA)‐derived with skin‐like piezo‐ionic are fabricated via a multi‐confined interaction network. This bionic network is constructed introducing diene comonomer lithium salt filler into polysulfides (poly (TA)), generating many dynamic interactions (various hydrogen bonds bonds). These can bind ions be destroyed under external pressure stimulation, achieving pumping behavior. unique design concept enables selectively respond (the optimal sample exhibits 152 times signal intensity sensitivity 49.53‐1.13 kPa −1 ), along leak prevention, recyclability, degradability. Besides, also serve sacrificial sites synergistically enhance all aspects yielding high modulus 2.47 MPa outstanding efficiency 98%. It believed that this work could create new approach for utilizing sustainable materials next‐generation “green” flexible sensors.

Language: Английский

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic DOI Creative Commons
Chiara Bellini, Fabrizio Mancin, Emanuele Papini

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 706 - 706

Published: June 9, 2024

α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, targeted delivery. Nanoformulations of significantly enhance its solubility absorption, making it more bioavailable. While be prone to degradation in free form, encapsulation within nanoparticles ensures stability over time, release controlled sustained manner the cells. In addition, combined other compounds, such as antioxidants, drugs, or nanomaterials, create synergistic effects their overall therapeutic benefits hinder potential cytotoxicity. This review outlines advantages drawbacks associated use acid, well various nanotechnological approaches employed effectiveness, whether alone combination bioactive agents. Furthermore, describes engineering produce poly(α-lipoic acid) nanoparticles, which hold promise an effective drug delivery system.

Language: Английский

Citations

4
Thioctic Acid-Based Solvent-Free and Recoverable Adhesive for Dry/Wet Environments DOI

Jiaxing Zhang,

Mengyue Wang,

X. J. Yao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Metal adhesive synthesis typically involves heating and solvents, the resultant adhesives lack degradability suffer from recycling sustainable problems. Herein, we developed a solvent-free chemically degradable biobased (p(Elp-TA)+PVP) thioctic acid (TA), its derivative (Elp), polyvinylpyrrolidone (PVP). Through rapid acid-triggered cationic ring-opening polymerization of dithiolane at ambient conditions, p(Elp-TA)+PVP could build up strong lap shear strength 1123 kPa in air an underwater 534 to copper plate. Molecular dynamics simulations show that compared p(Elp-TA), presence appropriate amount PVP can significantly enhance binding energy molecules metal substrate, adhesion substrates was achieved through synergistically dynamic adaptive network enhanced by hydrogen bonding, reversible coordination bonding 40 ps. More importantly, applied be easily degraded reverted small-molecular-weight lipoic species. Upon exposure dithiothreitol, green reducing agent, average molecular weight quickly decrease 1603 kDa 274 Da. This constructed simple method provides promising general strategy for developing controlled recoverable natural resources.

Language: Английский

Citations

4
Polymer-based antimicrobial strategies for periodontitis DOI Creative Commons
Jiajia Chen, Shujun Dong

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation bone destruction. Conventional therapies face challenges, including incomplete microbial clearance the rise of antibiotic resistance, limiting their precision effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches antimicrobial therapy through diverse mechanisms. This review explored specific mechanisms, emphasizing design polymer-based agents that employ individual or synergistic actions, evaluated innovations limitations current strategies while forecasting future trends development for

Language: Английский

Citations

0
Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection DOI Creative Commons
Hong Chen, Hui Zhang, Jiayi Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract Cisplatin‐induced ototoxicity is attributed to the aberrant accumulation of reactive oxygen species (ROS) within inner ear. Antioxidants represented by α‐lipoic acid (ALA) have been demonstrated scavenge ROS in cochlea, while effective delivery these agents vivo remains a major challenge. Here, novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable presented ALA deafness prevention. As composite exhibit excellent bioadhesion capabilities, this can result prolonged retention time allow precise under light stimulation, which significantly enhances therapeutic efficacy ALA. Based on features, both vitro experiments are that combined with near‐infrared irradiation effectively attenuate cisplatin‐induced ototoxicity. These findings suggest viable approach ear medication prevention deafness.

Language: Английский

Citations

0
Sustainable and recyclable ionogels for ionic thermoelectric supercapacitor application DOI

Yu-Syuan Jheng,

Ling‐Chieh Lee,

Shao‐Huan Hong

et al.

Journal of Materials Chemistry A, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This work develops a recyclable ionogel with dynamic cross-linked network. BMIM:Cl and CaCl 2 enhance thermoelectric properties, achieving −30.4 mV K −1 142.8 under 5 °C, advancing sustainable energy.

Language: Английский

Citations

0
Disulfide Incorporated Pyridine and Pyridinium Push–Pull Dyes for Optical Sensing and Antifouling Electrodes DOI
Andrew R. Brotherton,

Naedum DomNwachukwu,

Matthew D. Bailey

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

A new push-pull dye has been developed as a pH indicator when covalently copolymerized in lipoic acid-based polymer (LA-Py). Furthermore, various charged forms of the dyes are investigated antifouling diluents self-assembled monolayers (SAMs) on gold electrodes. The contain an amino donor incorporated into seven-membered heterocyclic disulfide ring, pyridine or pyridinium acceptor moiety, and oligo-phenylene ethylene (OPE) conjugated bridge. common characteristic is high sensitivity to solvent dipoles such Stokes shifts 176 211 nm for (Py) acetonitrile (MePy) chloroform, respectively. This coupled with decrease quantum yields increasing polarity solvents. LA-Py apparent pKa 3.5 showed acidic conditions robust cycling between 7 -0.08, producing average contrast 36% over 10 cycles. Incorporated SAM, zwitterionic sulfonate (SPy) derivative demonstrated BSA by continuous monitoring impedance electrochemical spectroscopy ionic permeability K3[FeCN6] cyclic voltammetry. When "backfilled" mercaptohexadecane (MHD), enhanced SAM was formed (SPy + MHD), which resistance ion penetration improved antifouling.

Language: Английский

Citations

0
Versatile Solid-State Medical Superglue Precursors of α-Lipoic Acid DOI
Subhajit Pal,

Salzman Ew,

Dominic Ramirez

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

α-Lipoic acid (αLA) is an attractive building block for medical adhesives. However, due to poor water solubility of αLA and high hydrophobicity poly(αLA), elevated temperatures, organic solvents, or complex preparations are typically required obtain deliver αLA-based adhesives biological tissue. Here, we report powder low-viscosity liquid superglues that polymerize bond rapidly upon contact with wet A monomeric mixture αLA, sodium lipoate, activated ester lipoic was used formulate the versatile Stress-strain measurements confirmed flexibility adhesive. Moreover, a small molecule regenerative drug successfully incorporated into released from adhesive without altering physical properties. In vitro in vivo studies developed their cell tissue compatibility, biodegradability, potential sustained delivery. inherent ionic nature adhesives, they demonstrated electric conductivity sensitivity deformation, allowing development tissue-adherent strain sensor.

Language: Английский

Citations

0
Novel Reusable Wood Adhesive Comprising Disulfide Bond–Modified Polyurethane DOI
Yujun Zhou,

Nan Xia,

Jialu Zhang

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Bioinspired Ionic Elastomer with Skin‐Like Piezo‐Ionic Dynamics Enabled by a Self‐Confined Multi‐Interaction Network DOI

Zhiyue Fang,

Lei Wang,

Cuiyuan Liang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Soft ionic elastomers have attracted considerable research interest in mimicking the multiple functions of human skin. However, these struggle to simultaneously achieve controllable ion dynamics and other essential performance, such as self‐healing ability appropriate mechanical robustness. Herein, bioinspired by Piezo proteins integrins skin, thioctic acid (TA)‐derived with skin‐like piezo‐ionic are fabricated via a multi‐confined interaction network. This bionic network is constructed introducing diene comonomer lithium salt filler into polysulfides (poly (TA)), generating many dynamic interactions (various hydrogen bonds bonds). These can bind ions be destroyed under external pressure stimulation, achieving pumping behavior. unique design concept enables selectively respond (the optimal sample exhibits 152 times signal intensity sensitivity 49.53‐1.13 kPa −1 ), along leak prevention, recyclability, degradability. Besides, also serve sacrificial sites synergistically enhance all aspects yielding high modulus 2.47 MPa outstanding efficiency 98%. It believed that this work could create new approach for utilizing sustainable materials next‐generation “green” flexible sensors.

Language: Английский

Citations

2