Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 271 - 271
Published: April 5, 2025
Collagen-based
wound
dressings
have
developed
as
an
essential
component
of
contemporary
care,
utilizing
collagen’s
inherent
properties
to
promote
healing.
This
review
thoroughly
analyzes
collagen
dressing
advances,
examining
different
formulations
such
hydrogels,
films,
and
foams
that
enhance
care.
The
important
processes
by
which
promotes
healing
(e.g.,
promoting
angiogenesis,
encouraging
cell
proliferation,
offering
structural
support)
are
discussed
clarify
its
function
in
tissue
regeneration.
effectiveness
adaptability
demonstrated
via
clinical
applications
investigated
acute
chronic
wounds.
Additionally,
commercially
accessible
collagen-based
skin
treatments
discussed,
demonstrating
their
practical
use
healthcare
settings.
Despite
the
progress,
study
discusses
obstacles
restrictions
encountered
producing
adopting
dressings,
difficulties
manufacturing
financial
concerns.
Finally,
current
landscape’s
insights
indicate
future
research
possibilities
for
optimization,
bioactive
agent
integration,
overcoming
existing
constraints.
analysis
highlights
potential
innovations
improve
treatment
methods
patient
Language: Английский
3D bioprinted alginate/gelatin hydrogel: concentration modulated properties toward scar-minimized wound healing
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 22
Published: April 16, 2025
The
critical
shortage
of
transplantable
skin
remains
a
leading
cause
mortality
in
patients
with
severe
injuries,
driving
the
demand
for
advanced
3D-bioprinted
constructs.
While
hydrogel-based
bioinks
are
pivotal
tissue
engineering,
existing
systems
often
fail
to
simultaneously
address
biomechanical
compatibility,
scar
suppression,
and
cell
viability.
Here,
we
propose
rationally
designed
sodium
alginate/gelatin
(SA/Gel)
hydrogel
platform
through
composition-property-performance
correlation
analysis.
Systematic
characterization
revealed
that
increasing
gelatin
content
(8-12
wt%)
enhanced
viscosity
(by
2.5-fold),
compressive
modulus
(25.6
±
2.7
kPa
37.9
3.5
kPa),
tensile
fracture
elongation
(57.9
4.2%
92.1
1.3%),
print
fidelity,
while
reducing
degradation
ratio
(62.8
2.9%
26.4
2.4%
at
day
14)
pore
size
(128.5
16.6
μm
79.4
19.7
μm).
optimized
A4G10
formulation
exhibited
synergistic
advantages:
(1)
dynamic
swelling
(36.3
0.8%)
balanced
nutrient
permeation
structural
stability;
(2)
tunable
(47.2%
matched
neo-tissue
formation;
(3)
anisotropic
mechanical
properties
(compressive
32.2
4.1
kPa,
31.7
3.9
kPa)
mimicked
native
mechanics;
(4)
sub-100
porous
architecture
(102.9
12.4
μm)
effectively
suppressed
fibroblast
over--proliferation.
Remarkably,
SA/Gel
scaffolds
maintained
98%
viability
(Live/Dead
assay)
vitro,
suppressing
fibrotic
formation
facilitating
angiogenesis
vivo.
This
multi-functional
system
demonstrates
unprecedented
potential
as
scar--inhibiting
bioink
clinical-grade
regeneration.
Language: Английский
Tendon regeneration deserves better: focused review on In vivo models, artificial intelligence and 3D bioprinting approaches
Damla Aykora,
No information about this author
Burak Taşçı,
No information about this author
Muhammed Zahid Şahin
No information about this author
et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 25, 2025
Tendon
regeneration
has
been
one
of
the
most
challenging
issues
in
orthopedics.
Despite
various
surgical
techniques
and
rehabilitation
methods,
tendon
tears
or
ruptures
cannot
wholly
regenerate
gain
load-bearing
capacity
tissue
had
before
injury.
The
enhancement
mostly
requires
grafting
an
artificial
tendon-like
to
replace
damaged
tendon.
engineering
offers
promising
regenerative
effects
with
numerous
additive
manufacturing
context.
3D
bioprinting
is
a
widely
used
method
produce
tissues
based
on
biocompatible
substitutes.
There
are
multiple
bio-inks
for
fabricating
innovative
scaffolds
applications.
Nevertheless,
there
still
many
drawbacks
overcome
successful
injured
tissue.
important
target
catch
highest
similarity
requirements
such
as
anisotropy,
porosity,
viscoelasticity,
mechanical
strength,
cell-compatible
constructs.
To
achieve
best-designed
structure,
novel
AI-based
systems
field
may
unveil
excellent
final
products
re-establish
integrity
functionality.
AI-driven
optimization
can
enhance
bio-ink
selection,
scaffold
architecture,
printing
parameters,
ensuring
better
alignment
biomechanical
properties
native
tendons.
Furthermore,
AI
algorithms
facilitate
real-time
process
monitoring
adaptive
adjustments,
improving
reproducibility
precision
fabrication.
Thus,
vitro
biocompatibility
vivo
application-based
experimental
processes
will
make
it
possible
accelerate
healing
reach
required
strength.
Integrating
predictive
modeling
further
refine
these
evaluate
performance,
cell
viability,
durability,
ultimately
translation
into
clinical
Here
this
review,
approaches
technology
incorporation
were
given
addition
models.
Language: Английский