Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Cellular Signalling, Journal Year: 2012, Volume and Issue: 24(5), P. 981 - 990

Published: Jan. 20, 2012

Language: Английский

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Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

Microbiology and Molecular Biology Reviews, Journal Year: 2011, Volume and Issue: 75(1), P. 50 - 83

Published: March 1, 2011

SUMMARY The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to intracellular responses. In mammals, there are more than a dozen MAPK enzymes that coordinately cell proliferation, differentiation, motility, and survival. best known the conventional MAPKs, which include signal-regulated 1 2 (ERK1/2), c-Jun amino-terminal 3 (JNK1 -3), p38 (α, β, γ, δ), ERK5 families. There additional, atypical enzymes, including ERK3/4, ERK7/8, Nemo-like kinase (NLK), have distinct regulation functions. Together, MAPKs large number of substrates, members family Ser/Thr termed MAPK-activated (MAPKAPKs). MAPKAPKs related respond stimulation through direct MAPK-dependent activation loop phosphorylation activation. five MAPKAPK subfamilies: p90 ribosomal S6 (RSK), mitogen- stress-activated (MSK), MAPK-interacting (MNK), 2/3 (MK2/3), MK5 (also as p38-regulated/activated [PRAK]). These biological functions, nucleosome gene expression, mRNA stability translation, proliferation Here we review mechanisms different discuss their physiological roles based on established substrates recent discoveries.

Language: Английский

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ROS and ROS‐Mediated Cellular Signaling

Oxidative Medicine and Cellular Longevity, Journal Year: 2016, Volume and Issue: 2016(1)

Published: Jan. 1, 2016

It has long been recognized that an increase of reactive oxygen species (ROS) can modify the cell‐signaling proteins and have functional consequences, which successively mediate pathological processes such as atherosclerosis, diabetes, unchecked growth, neurodegeneration, inflammation, aging. While numerous articles demonstrated impacts ROS on various signaling pathways clarify mechanism action proteins, their influence level intracellular ROS, complex interactions among multiple associated pathways, systemic summary is necessary. In this review paper, we particularly focus pattern generation homeostasis mechanisms targets impacting (NF‐ κ B, MAPKs, Keap1‐Nrf2‐ARE, PI3K‐Akt), ion channels transporters (Ca 2+ mPTP), modifying protein kinase Ubiquitination/Proteasome System.

Language: Английский

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Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Journal of Signal Transduction, Journal Year: 2011, Volume and Issue: 2011, P. 1 - 6

Published: Feb. 6, 2011

Mitogen-activated protein kinases (MAPKs) are serine-threonine that play the major role in signal transduction from cell surface to nucleus. MAPKs, which consist of growth factor-regulated extracellular signal-related (ERKs), and stress-activated c-jun NH 2 -terminal (JNKs) p38 part a three-kinase signaling module composed MAPK, an MAPK kinase (MAP2K) (MAP3K). MAP3Ks phosphorylate MAP2Ks, turn activate MAPKs. phosphatases (MKPs), recognize TXY amino acid motif present dephosphorylate deactivate pathways known be influenced not only by receptor ligand interactions, but also different stressors placed on cell. One type stress induces potential activation is oxidative caused reactive oxygen species (ROS). Generally, increased ROS production leads ERKs, JNKs, or mechanisms can these unclear. Oxidative modifications proteins inactivation and/or degradation MKPs may provide plausible for ROS, will reviewed this paper.

Language: Английский

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The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Cell, Journal Year: 2020, Volume and Issue: 182(3), P. 685 - 712.e19

Published: June 28, 2020

Language: Английский

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The molecular basis of retinal ganglion cell death in glaucoma

Progress in Retinal and Eye Research, Journal Year: 2011, Volume and Issue: 31(2), P. 152 - 181

Published: Dec. 9, 2011

Language: Английский

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p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

Cancer Letters, Journal Year: 2013, Volume and Issue: 344(2), P. 174 - 179

Published: Dec. 11, 2013

Language: Английский

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MAP Kinase Pathways

Cold Spring Harbor Perspectives in Biology, Journal Year: 2012, Volume and Issue: 4(11), P. a011254 - a011254

Published: Nov. 1, 2012

MAP kinases are activated within protein kinase cascades that regulate cell proliferation, differentiation, and death. In mammals, grouped into three families: ERKs, JNKs, p38/SAPKs.

Language: Английский

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Nature Cell Biology, Journal Year: 2013, Volume and Issue: 15(6), P. 555 - 564

Published: June 1, 2013

Language: Английский

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Controlling gene expression in response to stress

Nature Reviews Genetics, Journal Year: 2011, Volume and Issue: 12(12), P. 833 - 845

Published: Nov. 3, 2011

Language: Английский

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