The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

Nutrition Journal, Journal Year: 2015, Volume and Issue: 15(1)

Published: Dec. 1, 2015

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated etiology of numerous human diseases. Oxidative/Nitrosative result an disequilibrium oxidant/antioxidant which reveals from continuous increase Reactive Oxygen and Nitrogen Species production. The aim this review to emphasize with current information importance antioxidants play role cellular responce against stress, would be helpful enhancing knowledge any biochemist, pathophysiologist, or medical personnel regarding important issue. Products lipid peroxidation have commonly been used as biomarkers damage. Lipid generates a variety relatively stable decomposition end products, mainly α, β-unsaturated reactive aldehydes, such malondialdehyde, 4-hydroxy-2-nonenal, 2-propenal (acrolein) isoprostanes, can measured plasma urine indirect index stress. Antioxidants are exogenous endogenous molecules mitigate form its consequences. They may act directly scavenging free radicals increasing antioxidative defences. Antioxidant deficiencies develop decreased antioxidant intake, synthesis enzymes increased utilization. supplementation become increasingly popular practice maintain optimal body function. However, antoxidants exhibit pro-oxidant activity depending on specific set conditions. Of particular their dosage redox conditions cell.

Language: Английский

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Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

BioMed Research International, Journal Year: 2013, Volume and Issue: 2013, P. 1 - 15

Published: Jan. 1, 2013

The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. unique physicochemical electrical properties engineered nanoparticles (NP) make them highly desirable a variety applications. However, these novel NP are fraught with concerns for environmental occupational exposure. Changes structural can lead to changes biological activities including ROS generation, one most frequently reported NP-associated toxicities. Oxidative stress induced by is due acellular factors such as particle surface, size, composition, presence metals, while cellular responses mitochondrial respiration, NP-cell interaction, immune cell activation responsible ROS-mediated damage. NP-induced oxidative torch bearers further pathophysiological effects genotoxicity, inflammation, fibrosis demonstrated associated signaling pathways. Since key determinant injury, it necessary characterize response resulting from NP. Through characterization understanding multiple cascades activated ROS, systemic toxicity screen predictive model injury be developed.

Language: Английский

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Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 152, P. 116 - 141

Published: March 8, 2020

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic worldwide and is strongly associated with presence of oxidative stress. Disturbances in lipid metabolism lead to hepatic accumulation, which affects different reactive oxygen species (ROS) generators, including mitochondria, endoplasmic reticulum, NADPH oxidase. Mitochondrial function adapts NAFLD mainly through downregulation electron transport chain (ETC) preserved or enhanced capacity mitochondrial acid oxidation, stimulates ROS overproduction within ETC components upstream cytochrome c However, non-ETC sources ROS, particular, β-oxidation, appear produce more metabolic diseases. Endoplasmic reticulum stress oxidase alterations are also NAFLD, but degree their contribution remains unclear. Increased generation induces changes insulin sensitivity expression activity key enzymes involved metabolism. Moreover, interaction between redox signaling innate immune forms a complex network that regulates inflammatory responses. Based on mechanistic view described above, this review summarizes mechanisms may account for excessive production potential roles drive progression, therapeutic interventions related

Language: Английский

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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(10), P. 2499 - 2574

Published: Aug. 19, 2023

Abstract A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” characterized by low to mild levels oxidants involved in the regulation various biochemical transformations such carboxylation, hydroxylation, peroxidation, modulation signal transduction pathways Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2–related 2 (Nrf2) other processes. Increased ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result a harmful condition stress (“bad stress”). Although it widely accepted, that many chronic diseases are multifactorial origin, they share common denominator. Here we review importance mechanisms through which contributes pathological states an organism. Attention focused on chemistry ROS RNS (e.g. superoxide radical, hydrogen peroxide, hydroxyl radicals, peroxyl nitric oxide, peroxynitrite), their role damage DNA, proteins, membrane lipids. Quantitative qualitative assessment biomarkers also discussed. Oxidative pathology cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimer’s Parkinson’s Down syndrome), psychiatric (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, cancer), aging. The concerted action antioxidants ameliorate effect achieved antioxidant enzymes (Superoxide dismutases-SODs, catalase, glutathione peroxidase-GPx), small molecular weight (vitamins C E, flavonoids, carotenoids, melatonin, ergothioneine, others). Perhaps one most effective vitamin first line defense against peroxidation promising approach appears be use flavonoids), showing weak prooxidant properties may boost cellular systems thus act preventive anticancer agents. Redox metal-based enzyme mimetic compounds potential pharmaceutical interventions sirtuins therapeutic targets for age-related anti-aging strategies

Language: Английский

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TNF and ROS Crosstalk in Inflammation

Trends in Cell Biology, Journal Year: 2016, Volume and Issue: 26(4), P. 249 - 261

Published: Jan. 12, 2016

Language: Английский

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Modulating ROS to overcome multidrug resistance in cancer

Drug Resistance Updates, Journal Year: 2018, Volume and Issue: 41, P. 1 - 25

Published: Nov. 1, 2018

Language: Английский

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Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

Journal of Ethnopharmacology, Journal Year: 2018, Volume and Issue: 225, P. 342 - 358

Published: May 22, 2018

Language: Английский

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Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: Jan. 24, 2017

Abstract Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants ecosystem. Despite its global presence, there is still lack information on effect microplastics organisms at molecular level. Herein we demonstrated ingestion egestion nano- (0.05 μm) micro-sized (0.5 6 polystyrene microbeads copepod Paracyclopina nana , examined responses exposure with vivo endpoints such as growth rate fecundity. Also, proposed an outcome pathway for microplastic that covers individual levels. This study provides first insight into mode action terms microplastic-induced oxidative stress related signaling pathways P. .

Language: Английский

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The Two Faces of Reactive Oxygen Species in Cancer

Annual Review of Cancer Biology, Journal Year: 2016, Volume and Issue: 1(1), P. 79 - 98

Published: Aug. 27, 2016

Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling, facilitating cancer cell proliferation, survival, and adaptation to hypoxia. other antitumorigenic trigger oxidative stress-induced death. To hyperactivate pathways necessary transformation tumorigenesis, cells increase rate of production compared with normal cells. Concomitantly, order maintain homeostasis evade death, antioxidant capacity. Compared cells, this altered redox environment may susceptibility ROS-manipulation therapies. In review, we discuss two faces cancer, potential mechanisms underlying opposing therapeutic approaches targeting ROS.

Language: Английский

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Dual role of autophagy in hallmarks of cancer

Oncogene, Journal Year: 2017, Volume and Issue: 37(9), P. 1142 - 1158

Published: Dec. 14, 2017

Language: Английский

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