Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise DOI Creative Commons
Matthew S. Brook, Daniel J. Wilkinson, Bethan E. Phillips

et al.

Acta Physiologica, Journal Year: 2015, Volume and Issue: 216(1), P. 15 - 41

Published: May 25, 2015

Abstract Skeletal muscles comprise a substantial portion of whole body mass and are integral for locomotion metabolic health. Increasing age is associated with declines in both muscle function (e.g. strength‐related performance, power) quantitatively outweighing those volume. The mechanisms behind these multi‐faceted involving intrinsic age‐related dysregulation environmental influences such as nutritional physical activity. Ageing degree ‘anabolic resistance’ to key inputs, which likely accelerates the processes driving ageing. On this basis, strategies sensitize and/or promote anabolic responses nutrition activity be imperative alleviating progression trajectory sarcopenia. Both resistance‐ aerobic‐type exercises confer functional health benefits older age, clutch research suggests that enhancement responsiveness exercise may achieved by optimizing modifications muscle‐loading paradigms (workload, volume, blood flow restriction) or support essential amino acid/leucine) patterns. Nonetheless, more work needed holistic view ageing studies taken into account. This should include improved characterization study recruits, activity/nutritional behaviours, limit confounding variables influencing whether findings attributable other influences. on balance, partially related decline aerobic capacity. There also good evidence flexibility impaired age.

Language: Английский

The PI3K Pathway in Human Disease DOI Creative Commons
David A. Fruman, Honyin Chiu, Benjamin D. Hopkins

et al.

Cell, Journal Year: 2017, Volume and Issue: 170(4), P. 605 - 635

Published: Aug. 1, 2017

Language: Английский

Citations

2212

The Global Phosphorylation Landscape of SARS-CoV-2 Infection DOI Creative Commons
Mehdi Bouhaddou, Danish Memon, Bjoern Meyer

et al.

Cell, Journal Year: 2020, Volume and Issue: 182(3), P. 685 - 712.e19

Published: June 28, 2020

Language: Английский

Citations

1028

mTORC1 signaling and the metabolic control of cell growth DOI
Issam Ben‐Sahra, Brendan D. Manning

Current Opinion in Cell Biology, Journal Year: 2017, Volume and Issue: 45, P. 72 - 82

Published: April 1, 2017

Language: Английский

Citations

567

Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method DOI Creative Commons
Jia‐Ren Lin, Mohammad Fallahi‐Sichani, Peter K. Sorger

et al.

Nature Communications, Journal Year: 2015, Volume and Issue: 6(1)

Published: Sept. 24, 2015

Abstract Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case highly multiplexed methods such as mass cytometry (CyTOF) able to correlate levels multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy adds information on morphology microenvironment that are obtained using flow-based techniques, but multiplicity conventional IF is limited. This has motivated development imaging require specialized instrumentation, exotic reagents or proprietary protocols difficult reproduce most laboratories. Here we report a public-domain method for achieving high single-cell cyclic immunofluorescence (CycIF), simple versatile procedure which four-colour staining alternates with chemical inactivation fluorophores progressively build multichannel image. Because CycIF uses standard instrumentation no more expensive than IF, it suitable high-throughput assays screening applications.

Language: Английский

Citations

547

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells DOI
Antoine Marçais, Julien Cherfils‐Vicini, Charlotte Viant

et al.

Nature Immunology, Journal Year: 2014, Volume and Issue: 15(8), P. 749 - 757

Published: June 29, 2014

Language: Английский

Citations

541

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication DOI Creative Commons

Andrew Melber,

Cole M. Haynes

Cell Research, Journal Year: 2018, Volume and Issue: 28(3), P. 281 - 295

Published: Feb. 9, 2018

The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub innate immune apoptotic pathways. Multiple mechanisms have evolved to identify combat dysfunction maintain health organism. One such pathway unfolded protein response (UPR

Language: Английский

Citations

432

Multiple Roles of the Small GTPase Rab7 DOI Creative Commons
Flora Guerra, Cecilia Bucci

Cells, Journal Year: 2016, Volume and Issue: 5(3), P. 34 - 34

Published: Aug. 18, 2016

Rab7 is a small GTPase that belongs to the Rab family and controls transport late endocytic compartments such as endosomes lysosomes. The mechanism of action in pathway has been extensively studied. fundamental for lysosomal biogenesis, positioning functions, trafficking degradation several signaling receptors, thus also having implications on signal transduction. Several interacting proteins have being identified leading discovery number different important beside its established role endocytosis. Furthermore, specific functions neurons. This review highlights discusses importance cellular pathways processes.

Language: Английский

Citations

354

Cellular metabolic and autophagic pathways: Traffic control by redox signaling DOI
Matthew Dodson, Victor Darley‐Usmar, Jianhua Zhang

et al.

Free Radical Biology and Medicine, Journal Year: 2013, Volume and Issue: 63, P. 207 - 221

Published: May 20, 2013

Language: Английский

Citations

310

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice DOI Creative Commons
Aditi Bhattacharya, Hanoch Kaphzan, Amanda Alvarez-Dieppa

et al.

Neuron, Journal Year: 2012, Volume and Issue: 76(2), P. 325 - 337

Published: Oct. 1, 2012

Language: Английский

Citations

292

Growing knowledge of the mTOR signaling network DOI
Kezhen Huang, Diane C. Fingar

Seminars in Cell and Developmental Biology, Journal Year: 2014, Volume and Issue: 36, P. 79 - 90

Published: Sept. 19, 2014

Language: Английский

Citations

288