Biomedicine & Pharmacotherapy,
Journal Year:
2019,
Volume and Issue:
119, P. 109365 - 109365
Published: Sept. 13, 2019
Circular
RNAs
(circRNAs)
have
been
reported
to
play
critical
roles
in
tumorigenesis.
However,
the
of
circRNAs
laryngeal
squamous
cell
carcinoma
(LSCC)
are
still
largely
unknown.
In
our
present
study,
we
identified
a
novel
circRNA
hsa_circ_0042666,
which
was
poorly
expressed
LSCC.
Low
hsa_circ_0042666
expression
closely
associated
with
advanced
tumor
stage,
lymph-node
metastasis,
and
poor
overall
survival.
vitro
function
assays,
showed
that
dramatically
reduced
LSCC
cells
proliferation
invasion
vitro.
mechanism,
data
indicated
could
competitively
bind
miR-223
as
miRNA
sponge
regulate
TGFBR3
progression.
Altogether,
these
findings
elucidated
regulated
by
miR-223/TGFBR3
axis,
might
provide
therapeutic
strategy
for
treatment
Molecular Cancer,
Journal Year:
2019,
Volume and Issue:
18(1)
Published: July 5, 2019
Exosomes
have
emerged
as
critical
mediators
of
intercellular
communication,
both
locally
and
systemically,
by
regulating
a
diverse
range
biological
processes
between
cells.
Circular
RNA
(circRNA)
is
novel
member
endogenous
noncoding
RNAs
with
widespread
distribution
cellular
functions.
Recently,
circular
been
identified
for
their
enrichment
stability
in
exosomes.
In
this
review,
we
outline
the
origin,
biogenesis
function
exosomal
circRNAs
well
roles
various
diseases.
Although
precise
mechanisms
gene
regulation
remain
largely
elusive,
potential
applications
disease
biomarkers
therapeutic
targets.
Small,
Journal Year:
2021,
Volume and Issue:
17(35)
Published: June 2, 2021
Exosomes,
known
as
nanometer-sized
vesicles
(30-200
nm),
are
secreted
by
many
types
of
cells.
Cancer-derived
exosomes
have
great
potential
to
be
biomarkers
for
early
clinical
diagnosis
and
evaluation
cancer
therapeutic
efficacy.
Conventional
detection
methods
limited
low
sensitivity
reproducibility.
There
hundreds
papers
published
with
different
in
recent
years
address
these
challenges.
Therefore,
this
review,
pioneering
researches
about
various
strategies
comprehensively
summarized
the
analytical
performance
tests
is
evaluated.
Furthermore,
exosome
molecular
composition
(protein
nucleic
acid)
profiling,
a
single
their
application
reviewed.
Finally,
principles
applications
machine
learning
method
presented.
Molecular Therapy — Nucleic Acids,
Journal Year:
2019,
Volume and Issue:
19, P. 384 - 392
Published: Nov. 29, 2019
Exosomes
are
nano-sized
membrane-bound
vesicles
and
contain
active
substances
(DNA,
noncoding
RNA
[ncRNA],
protein),
which
provide
a
novel
method
of
transferring
effector
messages
between
cells.
Circular
RNAs
(circRNAs),
kind
ncRNA,
have
attracted
increasing
attention
over
the
last
decade
given
advances
in
whole-genome
transcriptome
sequencing
technologies.
It
has
become
increasingly
clear
that
circRNAs
regulate
gene
expression
through
various
actions
play
diverse
roles
many
fields
human
cancer
biology.
Notably,
several
studies
reported
enriched
exosomes
exosomal
an
important
role
Exosomal
can
be
taken
up
by
neighboring
or
distant
cells
affect
aspects
physiological
pathological
conditions
recipient
cells,
potentially
promoting
cell
communication
tumor
metastasis.
Herein,
we
briefly
review
molecular
mechanisms
recent
findings
regarding
circRNAs,
highlight
specific
cancer.
Theranostics,
Journal Year:
2021,
Volume and Issue:
12(1), P. 87 - 104
Published: Nov. 10, 2021
Exosomes
are
multifunctional
regulators
of
intercellular
communication
by
carrying
various
messages
under
both
physiological
and
pathological
status
cancer
patients.
Accumulating
studies
have
identified
the
presence
circular
RNAs
(circRNAs)
in
exosomes
with
crucial
regulatory
roles
diverse
pathophysiological
processes.
Exosomal
circRNAs
derived
from
donor
cells
can
modulate
crosstalk
recipient
locally
or
remotely
to
enhance
development
propagation,
play
tumor
microenvironment
(TME),
leading
significant
enhancement
immunity,
metabolism,
angiogenesis,
drug
resistance,
epithelial
mesenchymal
transition
(EMT),
invasion
metastasis.
In
this
review,
we
describe
advances
exosomal
their
modulating
hallmarks,
especially
those
TME.
Moreover,
clinical
application
potential
diagnosis
therapy
highlighted,
bridging
gap
between
basic
knowledge
practice.
Molecular Cancer,
Journal Year:
2020,
Volume and Issue:
19(1)
Published: Jan. 14, 2020
Abstract
Background
Circular
RNAs
(circRNAs)
are
a
new
class
of
endogenous
non-coding
(ncRNAs)
widely
expressed
in
eukaryotic
cells.
Mounting
evidence
has
highlighted
circRNAs
as
critical
regulators
various
tumours.
More
importantly,
have
been
revealed
to
recruit
and
reprogram
key
components
involved
the
tumour
microenvironment
(TME),
mediate
signaling
pathways,
thus
affecting
tumourigenesis,
angiogenesis,
immune
response,
metastatic
progression.
Main
body
abstract
In
this
review,
we
briefly
introduce
biogenesis,
characteristics
classification
circRNAs,
describe
mechanistic
models
circRNAs.
Further,
provide
first
systematic
overview
interplay
between
cellular/non-cellular
counterparts
TME
highlight
potential
prospective
biomarkers
or
targets
cancer
clinics.
Finally,
discuss
biological
mechanisms
through
which
drive
development
resistance,
revealing
mystery
drug
resistance
Short
conclusion
Deep
understanding
emerging
role
their
involvements
may
therapeutic
for
patients.
The
combined
targeting
co-activated
achieve
higher
efficiency
become
mode
therapy
future.
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: April 5, 2022
Abstract
Exosomes
are
microvesicles
secreted
by
cells.
They
contain
a
variety
of
bioactive
substances
with
important
roles
in
intercellular
communication.
Circular
RNA
(circRNA),
type
nucleic
acid
molecule
found
exosomes,
forms
covalently
bonded
closed
loop
without
5′
caps
or
3′
poly(A)
tails.
It
is
structurally
stable,
widely
distributed,
and
tissue
specific.
CircRNAs
mainly
act
as
microRNA
sponges
have
regulatory
gene
expression;
they
superior
to
other
non-coding
RNAs
molecular
diagnostic
markers
drug
treatment
targets.
Exosomal-derived
circRNAs
the
body
fluids
tumor
patients
can
modulate
proliferation,
invasion,
metastasis,
resistance.
be
used
effective
biomarkers
for
early
non-invasive
diagnosis
prognostic
evaluation
tumors,
also
represent
ideal
targets
precision
therapeutic
intervention.
This
review
provides
theoretical
basis
exploring
applications
exosomal
malignant
treatment.
We
describe
biological
functions
occurrence
development
their
potential
utility
treatment,
possible
mechanisms.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 14, 2025
Head
and
neck
squamous
cell
carcinoma
(HNSCC),
a
highly
invasive
malignancy
with
poor
prognosis,
is
one
of
the
most
common
cancers
globally.
Circular
RNAs
(circRNAs)
have
become
key
regulators
human
malignancies,
but
further
studies
are
necessary
to
fully
understand
their
functions
possible
causes
in
HNSCC.
CircCCT2
expression
levels
HNSCC
tissues
cells
were
measured
via
qPCR.
was
characterized
by
Sanger
sequencing,
qRT-PCR,
RNase
R
&
Actinomycin
D
treatment,
nucleoplasmic
separation
FISH
experiments.
CCK-8
colony
formation
assays
performed
determine
proliferation,
Transwell
used
migration
invasion.
A
xenograft
tumor
model
study
influence
circCCT2
on
vivo.
Dual-luciferase
gene
reporter,
RIP,
western
blotting,
rescue
experiments,
explore
target-binding
relationships
regulatory
mechanisms.
significantly
upregulated
cells.
High
associated
advanced
T
stage,
N
clinical
stage
prognosis.
Functionally,
we
verified
that
promotes
development
vitro
Mechanistically,
functioning
as
competitive
endogenous
RNA
(ceRNA)
or
miRNA
sponge,
binds
directly
miR-146a-5p
increases
interleukin-1
receptor-associated
kinase
1
(IRAK1)
levels,
which
enhances
malignant
driving
epithelial-mesenchymal
transition
(EMT).
through
miR-146a-5p/IRAK1
axis,
revealing
potential
biomarker
target
for
Frontiers in Molecular Biosciences,
Journal Year:
2020,
Volume and Issue:
6
Published: Jan. 10, 2020
Circular
RNAs
are
the
recent
addition
in
non-coding
RNA
family
which
has
started
gaining
recognition
after
a
decade
of
its
non-existence.
However,
first
few
reports
beginning
this
and
accumulating
evidences
thereafter
evoked
researchers
to
navigate
further
quest
for
exploration
circular
RNAs.
Joining
5'
3'
ends
molecules
by
backsplicing
forms
during
co-transcriptional
or
post-transcriptional
processes.
These
capable
effectively
sponging
microRNAs,
thereby
regulates
cellular
processess,
as
evidenced
from
numerous
animal
plant
systems.
Preliminary
studies
have
shown
that
imperative
role
transcriptional
regulation,
protein
translation,
possible
therapeutic
potential.
High
stability
is
rendered
closed
ends;
nevertheless
they
prone
degradation
circulating
endonucleases
serum
exosomes
microRNA-mediated
cleavage
due
high
complementarity.
identification
using
diverse
methodologies
delineating
mechanism
regulation
molecular
architecture
given
new
direction
research.
In
current
review,
we
discussed
biogenesis,
structure,
properties,
degradation,
growing
detection
methods
system.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 5, 2021
Extracellular
vesicles
(EVs)
exert
their
biological
functions
by
delivering
proteins,
metabolites,
and
nucleic
acids
to
recipient
cells.
EVs
play
important
roles
in
cancer
development.
The
anti-tumor
effect
of
is
cargos
carrying
affect
cell-to-cell
communication.
characteristics
communication
can
potentially
be
applied
for
the
therapy
cancers,
such
as
gastric
cancer.
In
addition,
used
an
effective
deliver
ncRNAs,
peptides,
drugs,
target
tumor
tissues.
have
ability
regulate
cell
apoptosis,
autophagy,
proliferation,
migration
ncRNA
peptides
that
were
engaged
with
associated
signaling
pathways
This
review
focuses
on
composition,
cargo,
function,
mechanism,
application
cancers.
