The role of gut microbiota and its metabolites short-chain fatty acids in food allergy

Food Science and Human Wellness, Journal Year: 2022, Volume and Issue: 12(3), P. 702 - 710

Published: Oct. 15, 2022

Emerging evidence indicated that the increase in food allergy (FA) over past few decades was associated with abnormal compositional and metabolic changes of gut microbiota. Gut microbiota played a vital role maintaining homeostasis immune system dysbiosis promoted occurrence FA. Recent research suggested short-chain fatty acids (SCFAs), main metabolites derived from microbiota, contributed to FA protection. Herein, we provided comprehensive review on relationship between The multifaceted mechanisms underlying beneficial effects composition/metabolites regulation diverse cellular pathways intestinal epithelial cells, dendritic innate lymphoid T B cells mast were discussed systematically. These findings emphasized positive function novel ideas for treatment or prevention future.

Language: Английский

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Vascular Calcification in Chronic Kidney Disease: An Update and Perspective

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(3), P. 673 - 673

Published: Jan. 1, 2022

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron numbers and function leading to end-stage renal mineral disorders. Vascular calcification, an ectopic deposition calcium-phosphate salts in blood vessel walls heart valves, independent risk factor cardiovascular morbidity mortality chronic disease. Moreover, aging related metabolic disorders are essential factors for vascular calcification. Marked progress has been recently made understanding treating calcification However, there paucity systematic reviews summarizing this progress, investigating unresolved issues warranted. In review, we aimed overview the underlying mechanisms diseases discuss impact on pathophysiology Additionally, summarized potential clinical diagnostic biomarkers therapeutic applications with This review may offer new insights into pathogenesis, diagnosis, intervention

Language: Английский

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Lysine Malonylation and Its Links to Metabolism and Diseases

Aging and Disease, Journal Year: 2022, Volume and Issue: 14(1), P. 84 - 84

Published: Nov. 17, 2022

Malonylation is a recently identified post-translational modification with malonyl-coenzyme A as the donor. It conserved both in prokaryotes and eukaryotes. Recent advances identification quantification of lysine malonylation by bioinformatic analysis have improved our understanding its role regulation protein activity, interaction, localization elucidated involvement many biological processes. has been linked to diverse physiological processes, including metabolic disorders, inflammation, immune regulation. This review discusses theory, describes underlying mechanism, summarizes recent progress research. The latest findings point novel functions highlight mechanisms which regulates variety cellular Our also marks association between malonylation, enzymes involved, various diseases, promising diagnostic therapeutic biomolecular targets for future clinical applications.

Language: Английский

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Research progress on post-translational modification of proteins and cardiovascular diseases

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 28, 2023

Abstract Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling, ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among the greatest threats to human health worldwide. pathogenesis has been studied for decades, influence of epigenetic changes on CVDs extensively studied. Post-translational modifications (PTMs), including phosphorylation, glycosylation, methylation, acetylation, ubiquitination, ubiquitin-like nitrification, play important roles in normal functioning cardiovascular system. Over past decade, with application high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), an increasing number novel acylation have discovered, propionylation, crotonylation, butyrylation, succinylation, lactylation, isonicotinylation. Each change protein conformation potential alter function lead CVDs, this process is usually reversible. This article summarizes mechanisms underlying several common PTMs involved occurrence development CVDs.

Language: Английский

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Dietary fiber intake and all-cause and cause-specific mortality: An updated systematic review and meta-analysis of prospective cohort studies

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 43(1), P. 65 - 83

Published: Nov. 15, 2023

Language: Английский

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