Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease DOI Creative Commons

Anchal Trisal,

Abhishek Kumar Singh

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 235 - 248

Published: Jan. 5, 2025

Language: Английский

The AMPK pathway in fatty liver disease DOI Creative Commons
Chunqiu Fang,

Jianheng Pan,

Ning Qu

et al.

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 25, 2022

Lipid metabolism disorders are the primary causes for occurrence and progression of various liver diseases, including non-alcoholic fatty disease (NAFLD) alcoholic (AFLD) caused by a high-fat diet ethanol. AMPK signaling pathway plays an important role in ameliorating lipid disorders. Progressive research has clarified that signal axes involved prevention reduction injury. Upregulation AMK can alleviate FLD mice induced alcohol or insulin resistance, type 2 diabetes, obesity, most natural agonists regulate metabolism, inflammation, oxidative stress hepatocytes, consequently regulating mice. In NAFLD AFLD, increasing activity inhibit synthesis acids cholesterol down-regulating expression adipogenesis gene (FAS, SREBP-1c, ACC HMGCR); Simultaneously, acid oxidation decomposition genes (CPT1, PGC1, HSL, ATGL) decomposition, body’s balance be maintained. At present, some activators thought to beneficial during therapeutic treatment. Therefore, activation is potential target liver. We summarized recent on this review. we performed detailed description each axis pathway, as well discussion its mechanism action significance.

Language: Английский

Citations

192
Senescence in the pathogenesis of age-related macular degeneration DOI
Janusz Błasiak

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 77(5), P. 789 - 805

Published: Jan. 2, 2020

Language: Английский

Citations

150
Polo-like kinase 1 (PLK1) signaling in cancer and beyond DOI

Styliani Iliaki,

Rudi Beyaert, Inna S. Afonina

et al.

Biochemical Pharmacology, Journal Year: 2021, Volume and Issue: 193, P. 114747 - 114747

Published: Aug. 26, 2021

Language: Английский

Citations

137
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy DOI
Saikat Dewanjee, V. Jayalakshmi, Rajkumar Singh Kalra

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 68, P. 101338 - 101338

Published: April 7, 2021

Language: Английский

Citations

136
Targeting lysosomes in human disease: from basic research to clinical applications DOI Creative Commons
Mengdie Cao, Xiangyuan Luo, Kongming Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Nov. 8, 2021

Abstract In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis. Lysosomal changes dysfunction have been correlated with development numerous diseases. this review, we interpreted key biological functions four areas: metabolism, cell proliferation differentiation, immunity, death. More importantly, actively sought to determine characteristic cells affected by these diseases, causes dysfunction, their significance treatment human disease. Furthermore, outlined currently available targeting strategies: (1) lysosomal acidification; (2) cathepsins; (3) membrane permeability integrity; (4) calcium signaling; (5) mTOR (6) emerging potential strategies. Moreover, systematically summarized corresponding drugs application clinical trials. By integrating basic research findings, discussed current opportunities challenges

Language: Английский

Citations

135
Targeting aging mechanisms: pharmacological perspectives DOI
Alexey Moskalev,

Zulfiya G. Guvatova,

Inês de Almeida Lopes

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2022, Volume and Issue: 33(4), P. 266 - 280

Published: Feb. 17, 2022

Language: Английский

Citations

104
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity DOI Creative Commons

Nina Vujović,

Matthew J. Piron,

Jingyi Qian

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1486 - 1498.e7

Published: Oct. 1, 2022

Language: Английский

Citations

92
Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine DOI Open Access

Min-Rui Ding,

Yan-Jie Qu,

Bing Hu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113208 - 113208

Published: May 31, 2022

This study aimed to reveal the classical signal pathways and important potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD), provide support further investigation on TCM its active ingredients.Literature survey was conducted using PubMed, Web Science, Google Scholar, CNKI, other databases, with "Alzheimer's disease," "traditional medicine," "medicinal herb," "Chinese "natural plant" as primary keywords.TCM could modulate related AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, PI3K/Akt/mTOR, well SIRT1 PPARα pathway. It regulate crosstalk between through a multitarget, thus maintaining chronic inflammatory interaction balance, inhibiting oxidative stress damage, regulating system function, modulating autophagy, eventually improving cognitive impairment in patients AD.TCM be multilevel, multitargeted, multifaceted prevent treat AD. In-depth research prevention treatment new ideas exploring pathogenesis developing anti-AD drugs.

Language: Английский

Citations

91
Disorders of cancer metabolism: The therapeutic potential of cannabinoids DOI Open Access
Dingya Sun, Xin Li, Shengdan Nie

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 113993 - 113993

Published: Nov. 12, 2022

Abnormal energy metabolism, as one of the important hallmarks cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival development, it has been considered a potential target cancer therapy. Cannabinoids have shown to exhibit variety anticancer activities unclear mechanisms. This paper first reviews recent progress related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), p53) mediating metabolism (including glucose amino acid metabolism). Then we comprehensively explore latest discoveries possible mechanisms effects cannabinoids through regulation above-mentioned pathways, provide new targets insights prevention treatment.

Language: Английский

Citations

79
The autophagy–NAD axis in longevity and disease DOI Creative Commons

Niall Wilson,

Tetsushi Kataura,

Miriam E. Korsgen

et al.

Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 33(9), P. 788 - 802

Published: March 5, 2023

Autophagy is an intracellular degradation pathway that recycles subcellular components to maintain metabolic homeostasis. NAD essential metabolite participates in energy metabolism and serves as a substrate for series of NAD+-consuming enzymes (NADases), including PARPs SIRTs. Declining levels autophagic activity represent features cellular ageing, consequently enhancing either significantly extends health/lifespan animals normalises cells. Mechanistically, it has been shown NADases can directly regulate autophagy mitochondrial quality control. Conversely, preserve by modulating stress. In this review we highlight the mechanisms underlying bidirectional relationship between autophagy, potential therapeutic targets provides combatting age-related disease promoting longevity.

Language: Английский

Citations

59