Lipids in Health and Disease,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: July 7, 2021
Obesity
and
its
complications
constitute
a
substantial
burden.
Considerable
published
research
describes
the
novel
relationships
between
obesity
gut
microbiota
communities.
It
is
becoming
evident
that
behave
in
pivotal
role
their
ability
to
influence
homeostatic
mechanisms
either
benefit
or
detriment
of
host
health,
extent
which
not
fully
understood.
A
greater
understanding
contribution
towards
pathophysiology
revealing
new
therapeutic
avenues
tackle
global
epidemic.
This
review
focuses
on
causal
associations
with
obesity,
proposed
central
encouraging
development
promising
prospective
methods
for
manipulation.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
189, P. 106687 - 106687
Published: Feb. 4, 2023
Accumulating
evidence
indicates
gut
microbiota
contributes
to
aging-related
disorders.
However,
the
exact
mechanism
underlying
dysbiosis-related
pathophysiological
changes
during
aging
remains
largely
unclear.
In
current
study,
we
first
performed
remodeling
on
old
mice
by
fecal
transplantation
(FMT)
from
young
mice,
and
then
characterized
bacteria
signature
that
was
specifically
altered
FMT.
Our
results
revealed
FMT
significantly
improved
natural
systemic
disorders,
particularly
exerted
hepatoprotective
effects,
glucose
sensitivity,
hepatosplenomegaly,
inflammaging,
antioxidative
capacity
intestinal
barrier.
Moreover,
increased
abundance
of
A.muciniphila,
which
almost
nondetectable
in
mice.
Interestingly,
A.muciniphila
supplementation
also
similar
benefits
with
Notably,
targeted
metabolomics
short
chain
fatty
acids
(SCFAs)
only
acetic
acid
consistently
reversed
Then,
intervention
beneficial
actions
both
Caenorhabditis
elegans
conclusion,
our
study
demonstrated
disorders
through
its
derived
acid,
suggesting
interventions
potent
stimulative
A.
muciniphila
growth
production
alternative
effective
way
maintain
healthy
aging.
The
data
RNAseq
16
S
rRNA
gene
sequencing
can
be
accessed
NCBI
accession
number
PRJNA848996
PRJNA849355.
Hepatology,
Journal Year:
2022,
Volume and Issue:
76(6), P. 1811 - 1824
Published: May 13, 2022
Abstract
Background
and
Aims
Bile
acids
are
hepatic
metabolites
have
many
properties
considered
to
be
relevant
the
pathophysiology
of
NAFLD.
Circulating
levels
intestinal
microbiome‐modified
bile
acid
deoxycholate
increased
in
cirrhosis.
Approach
Results
To
further
elucidate
role
microbiota
linked
progressively
severe
NAFLD,
a
multiomic
study
feces
including
16S
rRNA
sequencing,
microbial
transcriptomics
metabolomics
was
performed
cohort
with
varying
phenotypes
Several
origin
derived
from
deoxycholic
(DCA)
(glycodeoxycholate,
7‐ketodeoxycholic
acid,
dehydrocholic
acid)
disease
activity
fibrosis
stage.
These
were
expression
salt
hydrolase,
operon
(BaiCD)
hydroxysteroid
dehydrogenases
(hdhA)
required
for
DCA
downstream
metabolite
synthesis
providing
mechanistic
basis
altered
profiles
progression.
Bacteroidetes
several
genera
Lachnospiraceae
family
containing
generating
genes
increasing
severity,
whereas
potentially
beneficial
microbes
sensitive
antibacterial
effects
e.g.,
Ruminococcaceae
decreased.
The
clinical
relevance
these
data
confirmed
an
independent
enrolled
trial
NASH
where
at
entry
its
conjugates
associated
advanced
fibrosis.
In
patients
treated
placebo,
declined
those
regression
rose
compensated
cirrhosis
when
they
experienced
decompensation.
Conclusions
findings
demonstrate
dependent
microbiome
development
progression
NAFLD
set
stage
leverage
biomarker
therapeutics.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 24, 2023
Background
Probiotics
play
a
vital
role
in
treating
immune
and
inflammatory
diseases
by
improving
intestinal
barrier
function;
however,
comprehensive
evaluation
is
missing.
The
present
study
aimed
to
explore
the
impact
of
probiotics
on
related
function,
inflammation,
microbiota
composition.
A
systematic
review
meta-analyses
were
conducted.
Methods
Four
major
databases
(PubMed,
Science
Citation
Index
Expanded,
CENTRAL,
Embase)
thoroughly
searched.
Weighted
mean
differences
calculated
for
continuous
outcomes
with
corresponding
95%
confidence
intervals
(CIs),
heterogeneity
among
studies
was
evaluated
utilizing
I2
statistic
(Chi-Square
test),
data
pooled
using
random
effects
meta-analyses.
Results
Meta-analysis
from
total
26
RCTs
(n
=
1891)
indicated
that
significantly
improved
gut
function
measured
levels
TER
(MD,
5.27,
CI,
3.82
6.72,
P
<
0.00001),
serum
zonulin
(SMD,
-1.58,
-2.49
-0.66,
0.0007),
endotoxin
-3.20,
-5.41
-0.98,
0.005),
LPS
-0.47,
-0.85
-0.09,
0.02).
Furthermore,
probiotic
groups
demonstrated
better
efficacy
over
control
reducing
factors,
including
CRP,
TNF-α,
IL-6.
can
also
modulate
structure
boosting
enrichment
Bifidobacterium
Lactobacillus.
Conclusion
work
revealed
could
improve
alleviate
inflammation
microbial
dysbiosis.
Further
high-quality
are
warranted
achieve
more
definitive
conclusion.
Clinical
trial
registration
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=281822
,
identifier
CRD42021281822.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Arsenic
has
been
ranked
as
the
most
hazardous
substance
by
U.S.
Agency
for
Toxic
Substances
and
Disease
Registry.
Environmental
arsenic
exposure-evoked
health
risks
have
become
a
vital
public
concern
worldwide
owing
to
widespread
existence
of
arsenic.
Multi-omics
is
revolutionary
technique
data
analysis
providing
an
integrated
view
bioinformation
comprehensively
systematically
understanding
elaborate
mechanism
diseases.
This
study
aimed
at
uncovering
potential
contribution
liver-microbiota-gut
axis
in
chronic
inorganic
exposure-triggered
biotoxicity
chickens
based
on
multi-omics
technologies.
Forty
Hy-Line
W-80
laying
hens
were
chronically
exposed
sodium
arsenite
with
dose-dependent
manner
(administered
drinking
water
containing
10,
20,
or
30
mg/L
arsenic,
respectively)
42
d,
followed
transcriptomics,
serum
non-targeted
metabolome,
16S
ribosomal
RNA
gene
sequencing
accordingly.
intervention
induced
serious
chicken
liver
dysfunction,
especially
severe
fibrosis,
simultaneously
altered
ileal
microbiota
populations,
impaired
intestinal
barrier,
further
drove
enterogenous
lipopolysaccharides
translocation
via
portal
vein
circulation
aggravating
damage.
Furtherly,
injured
disturbed
bile
acids
(BAs)
homoeostasis
through
strongly
up-regulating
BAs
synthesis
key
rate-limiting
enzyme
CYP7A1,
inducing
excessive
total
accumulation,
accompanied
massive
primary
BA—chenodeoxycholic
acid.
Moreover,
concentrations
secondary
BAs—ursodeoxycholic
acid
lithocholic
markedly
repressed,
which
might
involve
repressed
dehydroxylation
Ruminococcaceae
Lachnospiraceae
families.
Abnormal
metabolism
turn
promoted
injury,
ultimately
perpetuating
pernicious
circle
chickens.
Notably,
obvious
depletion
abundance
four
profitable
microbiota,
Christensenellaceae,
Ruminococcaceae,
Muribaculaceae,
Faecalibacterium,
correlated
tightly
this
hepato-intestinal
process
Our
demonstrates
that
exposure
evokes
disruption
establishes
scientific
basis
evaluating
risk
environmental
pollutant
