Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions DOI Creative Commons
Mikhail Syromyatnikov, Ekaterina Nesterova,

Maria Gladkikh

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(9), P. 1866 - 1866

Published: Sept. 18, 2022

High-throughput sequencing has made it possible to extensively study the human gut microbiota. The links between microbiome and ethnicity, religion, race remain rather poorly understood. In this review, data on relationship microbiota composition nationality of people their religion were generalized. unique a healthy European (including Slavic nationality) is characterized by dominance phyla Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria, Fusobacteria, Verrucomicrobia. Among African population, typical members are Bacteroides Prevotella. Asians very diverse rich in genera Prevotella, Lactobacillus, Faecalibacterium, Ruminococcus, Subdoligranulum, Coprococcus, Collinsella, Megasphaera, Bifidobacterium, Phascolarctobacterium. Buddhists Muslims, Prevotella enterotype characteristic microbiome, while other representatives religions, including Christians, have enterotype. Most likely, different nationalities religions influenced food preferences. review also considers influences pathologies such as obesity, Crohn’s disease, cancer, diabetes, etc., bacterial guts nationalities.

Language: Английский

Prevotella diversity, niches and interactions with the human host DOI
Adrian Tett, Edoardo Pasolli, Giulia Masetti

et al.

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(9), P. 585 - 599

Published: May 28, 2021

Language: Английский

Citations

452
The gut microbiome as a modulator of healthy ageing DOI Open Access
Tarini Shankar Ghosh, Fergus Shanahan, Paul W. O’Toole

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(9), P. 565 - 584

Published: April 25, 2022

Language: Английский

Citations

428
The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic DOI
Ai Huey Tan, Shen‐Yang Lim, Anthony E. Lang

et al.

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(8), P. 476 - 495

Published: June 24, 2022

Language: Английский

Citations

209
PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion DOI Creative Commons
Alba Tamargo, Natalia Molinero, J.J. Reinosa

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 11, 2022

Abstract Microplastics (MPs) are a widely recognized global problem due to their prevalence in natural environments and the food chain. However, impact of microplastics on human microbiota possible biotransformation gastrointestinal tract have not been well reported. To evaluate potential risks at digestive level, completely passing single dose polyethylene terephthalate (PET) through was simulated by combining harmonized static model dynamic simgi model, which recreates different regions physiological conditions. PET MPs started several biotransformations and, colon, appeared be structurally from original particles. We report that feeding with alters microbial colonic community composition hypothesize some members could adhere surface promoting formation biofilms. The work presented here indicates indeed capable digestive-level health effects. Considering this evidence increasing exposure consumer foods beverages, plastics functionality gut microbiome biodegradation digestion intestinal bacteria merits critical investigation.

Language: Английский

Citations

183
Interplay Between Exercise and Gut Microbiome in the Context of Human Health and Performance DOI Creative Commons
Matthieu Clauss, Philippe Gérard, Alexis Mosca

et al.

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: June 10, 2021

Gut microbiota and exercise have recently been shown to be interconnected. Both moderate intense are typically part of the training regimen endurance athletes, but they exert different effects on health. Moderate has positive health average such as a reduction in inflammation intestinal permeability an improvement body composition. It also induces changes gut composition microbial metabolites produced gastrointestinal tract. Conversely, can increase epithelial wall diminish mucus thickness, potentially enabling pathogens enter bloodstream. This, turn, may contribute levels. However, elite athletes seem higher diversity, shifted toward bacterial species involved amino acid biosynthesis carbohydrate/fiber metabolism, consequently producing key short-chain fatty acids. Moreover, rodent studies highlighted bidirectional relationship, with impacting while influence performance. The present review focuses sports how this interconnection depends upon intensity training. After pointing out limits so far available, we suggest that taking into account its metabolic contribution human host could help monitoring modulating athletes' Such integrated approach should design microbiome-based solutions for or

Language: Английский

Citations

178
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions DOI Creative Commons
Bin Wang, Lei Zhang, Yongqiang Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 29, 2022

The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It caused by severe acute respiratory syndrome 2 (SARS-CoV-2). A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea, nausea, or vomiting. Moreover, the and tracts are primary habitats human microbiota targets for SARS-CoV-2 infection they express angiotensin-converting enzyme-2 (ACE2) transmembrane protease serine (TMPRSS2) at levels. There accumulating evidence that significantly altered in with post-acute (PACS). Microbiota powerful immunomodulatory factors various diseases, diabetes, obesity, cancers, ulcerative colitis, Crohn's disease, certain viral infections. In present review, we explore associations between host terms their clinical relevance. Microbiota-derived metabolites components main mediators microbiota-host interactions influence immunity. Hence, discuss potential mechanisms which microbiota-derived modulate immune responses to infection. Finally, review a variety possible microbiota-based prophylaxes therapies PACS, including fecal transplantation (FMT), probiotics, prebiotics, metabolites, engineered symbiotic bacteria. This treatment strategy could mitigate virus-induced inflammation.

Language: Английский

Citations

155
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy DOI Creative Commons

Connor Campbell,

Mrunmayee Kandalgaonkar, Rachel M. Golonka

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 294 - 294

Published: Jan. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Language: Английский

Citations

116
Alcohol-associated liver disease DOI Creative Commons
Bryan Mackowiak, Yaojie Fu, Luca Maccioni

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(3)

Published: Feb. 1, 2024

Alcohol-associated liver disease (ALD) is a major cause of chronic worldwide, and comprises spectrum several different disorders, including simple steatosis, steatohepatitis, cirrhosis, superimposed hepatocellular carcinoma. Although tremendous progress has been made in the field ALD over last 20 years, pathogenesis remains obscure, there are currently no FDA-approved drugs for treatment ALD. In this Review, we discuss new insights into therapeutic targets ALD, utilizing study multiomics other cutting-edge approaches. The potential translation these studies clinical practice therapy deliberated. We also preclinical models interplay metabolic dysfunction, alcohol-associated cancer, heterogeneity some translational research prospects

Language: Английский

Citations

112
The interplay between diet and the gut microbiome: implications for health and disease DOI
Fiona C. Ross, Dhrati Patangia, Ghjuvan Micaelu Grimaud

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 671 - 686

Published: July 15, 2024

Language: Английский

Citations

112
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics DOI Open Access
Dan Li, Yujuan Li, Shengjie Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113290 - 113290

Published: June 17, 2022

The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human society owing to the ensuing high morbidity mortality. Various factors linked disorders, particularly environmental (such as diet gut microbiota) epigenetic modifications, contribute progression diseases. Dietary components habits regulate alterations microbiota; turn, microbiota-derived metabolites, such short-chain acids (SCFAs), are influenced by diet. Interestingly, diet-derived microbial metabolites appear produce substrates enzymatic regulators for modifications DNA methylation, histone non-coding RNA expression). Epigenetic changes mediated participate disorders via intestinal permeability, immune responses, inflammatory reactions, insulin resistance. In addition, can trigger responses microbiota dysbiosis directly binding G-protein-coupled receptors (GPCRs). Hence, diet-gut microbiota-epigenetics may play role However, their complex relationships with diseases remain largely unknown require further investigation. This review aimed elaborate on interactions among diet, microbiota, epigenetics uncover mechanisms therapeutics

Language: Английский

Citations

97