International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9366 - 9366
Published: Aug. 29, 2024
The
human
gastrointestinal
tract
hosts
a
complex
and
dynamic
community
of
microorganisms
known
as
the
gut
microbiota,
which
play
pivotal
role
in
numerous
physiological
processes,
including
digestion,
metabolism,
immune
function.
Recent
research
has
highlighted
significant
impact
diet
on
microbiota
composition
functionality,
consequential
effects
host
health.
Concurrently,
there
is
growing
evidence
linking
to
inflammation,
key
factor
many
chronic
diseases
such
inflammatory
bowel
disease
(IBD),
obesity,
diabetes,
cardiovascular
(CVDs).
This
review
explores
how
dietary
components
influence
composition,
these
microbial
changes
affect
pathways,
therapeutic
implications
modulating
this
axis
for
prevention
management.
Beneficial
patterns,
Mediterranean
(MD)
plant-based
diets,
promote
diverse
balanced
supporting
anti-inflammatory
pathways.
Conversely,
Western
(WD),
high
saturated
fats
refined
sugars,
associated
with
dysbiosis
increased
inflammation.
With
all
links
between
three
variables
considered,
attempts
offer
thorough
examination
triangle
formed
by
food.
BMJ,
Journal Year:
2024,
Volume and Issue:
unknown, P. e077310 - e077310
Published: Feb. 28, 2024
Abstract
Objective
To
evaluate
the
existing
meta-analytic
evidence
of
associations
between
exposure
to
ultra-processed
foods,
as
defined
by
Nova
food
classification
system,
and
adverse
health
outcomes.
Design
Systematic
umbrella
review
meta-analyses.
Data
sources
MEDLINE,
PsycINFO,
Embase,
Cochrane
Database
Reviews,
well
manual
searches
reference
lists
from
2009
June
2023.
Eligibility
criteria
for
selecting
studies
reviews
meta-analyses
cohort,
case-control,
and/or
cross
sectional
study
designs.
credibility
evidence,
pre-specified
were
applied,
graded
convincing
(“class
I”),
highly
suggestive
II”),
III”),
weak
IV”),
or
no
V”).
The
quality
was
assessed
using
GRADE
(Grading
Recommendations,
Assessment,
Development,
Evaluations)
framework,
categorised
“high,”
“moderate,”
“low,”
“very
low”
quality.
Results
search
identified
45
unique
pooled
analyses,
including
13
dose-response
32
non-dose-response
(n=9
888
373).
Overall,
direct
found
foods
(71%)
parameters
spanning
mortality,
cancer,
mental,
respiratory,
cardiovascular,
gastrointestinal,
metabolic
Based
on
criteria,
(class
I)
supported
greater
higher
risks
incident
cardiovascular
disease
related
mortality
(risk
ratio
1.50,
95%
confidence
interval
1.37
1.63;
GRADE=very
low)
type
2
diabetes
(dose-response
risk
1.12,
1.11
1.13;
moderate),
prevalent
anxiety
outcomes
(odds
1.48,
1.59;
combined
common
mental
disorder
1.53,
1.43
low).
Highly
II)
indicated
that
directly
associated
with
all
cause
1.21,
1.15
1.27;
low),
heart
(hazard
1.66,
1.51
1.84;
1.40,
1.23
very
depressive
1.22,
1.16
1.28;
together
sleep
1.41,
1.24
1.61;
wheezing
1.27
1.55;
obesity
1.55,
1.36
1.77;
Of
remaining
34
21
strength
III-IV)
V).
22
analyses
rated
low
quality,
19
four
moderate
Conclusions
Greater
a
outcomes,
especially
cardiometabolic,
disorder,
These
findings
provide
rationale
develop
effectiveness
population
based
public
measures
target
reduce
dietary
improved
human
health.
They
also
inform
support
urgent
mechanistic
research.
registration
PROSPERO
CRD42023412732.
Annual Review of Physiology,
Journal Year:
2022,
Volume and Issue:
85(1), P. 449 - 468
Published: Nov. 14, 2022
The
interplay
between
diet,
the
gut
microbiome,
and
host
health
is
complex.
Diets
associated
with
have
many
similarities:
high
fiber,
unsaturated
fatty
acids,
polyphenols
while
being
low
in
saturated
fats,
sodium,
refined
carbohydrates.
Over
past
several
decades,
dietary
patterns
changed
significantly
Westernized
nations
increased
consumption
of
calorically
dense
ultraprocessed
foods
fiber
salt,
carbohydrates,
leading
to
numerous
negative
consequences
including
obesity,
metabolic
syndrome,
cardiovascular
disease.
microbiota
an
environmental
factor
that
interacts
diet
may
also
impact
on
outcomes,
which
involve
metabolites
produced
by
from
components
can
host.
This
review
focuses
our
current
understanding
complex
relationship
microbiota,
health,
examples
how
support
increase
individual's
risk
for
disease,
be
used
as
a
therapy
specific
diseases.
Gut,
Journal Year:
2022,
Volume and Issue:
72(1), P. 180 - 191
Published: Sept. 28, 2022
Accumulating
evidence
indicates
that
gut
transit
time
is
a
key
factor
in
shaping
the
microbiota
composition
and
activity,
which
are
linked
to
human
health.
Both
population-wide
small-scale
studies
have
identified
as
top
covariate
contributing
large
interindividual
variation
faecal
composition.
Despite
this,
still
rarely
being
considered
field
of
microbiome.
Here,
we
review
latest
research
describing
how
why
whole
segmental
times
vary
substantially
between
within
individuals,
variations
impact
composition,
diversity
metabolism.
Furthermore,
discuss
mechanisms
by
may
causally
affect
motility.
We
argue
taking
into
account
intraindividual
differences
time,
can
advance
our
understanding
diet–microbiota
interactions
disease-related
microbiome
signatures,
since
these
often
be
confounded
transient
or
persistent
alterations
time.
Altogether,
better
complex,
bidirectional
required
understand
health
disease.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(13), P. 2568 - 2568
Published: June 21, 2022
Since
previous
meta-analyses,
which
were
limited
only
to
depression
and
by
a
small
number
of
studies
available
for
inclusion
at
the
time
publication,
several
additional
have
been
published
assessing
link
between
ultra-processed
food
consumption
as
well
other
mental
disorders.
We
aimed
build
on
previously
conducted
reviews
synthesise
meta-analyse
contemporary
evidence
base
clarify
associations
A
total
17
observational
included
(
