British Journal of Cancer, Journal Year: 2023, Volume and Issue: 128(6), P. 1155 - 1165
Published: Jan. 4, 2023
Language: Английский
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)
Published: March 16, 2023
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular signaling pathways necessary for normal tissue immune function. Associative mechanistic studies have identified species whose presence may increase CRC risk, including notable examples such as Fusobacterium nucleatum, Enterotoxigenic Bacteroides fragilis, pks+ E. coli. In recent years this work has expanded in scope to include aspects host mutational status, intra-tumoral microbial heterogeneity, transient infection, cumulative influence multiple carcinogenic bacteria after sequential co-colonization. review, we will provide an updated overview how host-bacteria interactions development, knowledge be utilized diagnose prevent CRC, gut microbiome influences treatment efficacy.
Language: Английский
Citations
55
British Journal of Cancer, Journal Year: 2024, Volume and Issue: 130(5), P. 728 - 740
Published: Jan. 10, 2024
Abstract Background This study aimed to investigate clinicopathological and molecular tumour features associated with intratumoral pks + Escherichia coli ( E.coli ), - (non- bacteria harbouring the island), Enterotoxigenic Bacteroides fragilis (ETBF) Fusobacterium nucleatum F. ). Methods We screened 1697 tumour-derived DNA samples from Australasian Colorectal Cancer Family Registry, Melbourne Collaborative Cohort Study ANGELS using targeted PCR. Results Pks was male sex P < 0.01) APC :c.835-8 A > G somatic mutation = 0.03). The association between specific early-onset CRCs (diagnosed<45years, 0.02). :c.835-A not 0.36). mismatch repair deficiency (MMRd), BRAF: c.1799T>A p.V600E mutation, CpG island methylator phenotype, proximal location, high levels of infiltrating lymphocytes s 0.01). In stratified analysis by MMRd subgroups, Lynch syndrome, MLH1 methylated double MMR mutated subgroups Ps Conclusion Intratumoral but are suggesting that this is specifically related damage colibactin-producing exposures . both hereditary sporadic subtypes, microenvironment important for colonisation irrespective its cause.
Language: Английский
Citations
19
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2133 - 2147
Published: July 31, 2024
Language: Английский
Citations
19
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189281 - 189281
Published: Feb. 8, 2025
Language: Английский
Citations
2
Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Language: Английский
Citations
2
Gut, Journal Year: 2022, Volume and Issue: 71(10), P. 2107 - 2122
Published: July 12, 2022
Cancer is generally regarded as a localised disease, with the well-established role of tumour microenvironment. However, realm cancer goes beyond microenvironment, and should also be systemic environmental disease. The exposome ( ie, totality exposures), which encompasses diets, supplements, smoking, alcohol, other lifestyle factors, medications, etc , likely alters microbiome (inclusive bacteria, viruses, archaea, fungi, parasites, ) immune system in various body sites influences phenotypes. metabolic/inflammatory status, influenced by exposures intestinal physiological changes, may affect tissue microenvironment colorectum any organs. Germline genomic factors can modify disease phenotypes via gene-by-environment interactions. Although challenges exist, it crucial to advance not only basic experimental research that analyse effects exposures, microorganisms microenvironmental components on evolution but interdisciplinary human population dissect complex pathogenic roles exposome, immunome. Metagenomic, metatranscriptomic metabolomic analyses integrated into well-designed combined advanced methodologies artificial intelligence molecular pathological epidemiology. Ideally, prospective cohort study design enables biospecimen (such stool) collection before detection considered address reverse causation recall biases. Robust observational together provide insights dynamic interactions between microbiota, immunity during carcinogenesis processes, thereby helping us develop precision prevention therapeutic strategies ultimately reduce burden.
Language: Английский
Citations
55
MedComm, Journal Year: 2023, Volume and Issue: 4(2)
Published: Feb. 26, 2023
Colonies formed by bacteria, archaea, fungi, and viral groups their genomes, metabolites, expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis disease progression were link to Different organ sources, microbial species, metabolites are different; the mechanisms of carcinogenic or procancerous also different. Here, we summarize how microbiomes contribute in cancers skin, mouth, esophagus, lung, gastrointestinal, genital, blood, lymph malignancy. We insight into molecular triggering, promoting, inhibiting progress induced or/and secretions bioactive metabolites. And then, strategies application microorganisms cancer treatment discussed detail. However, which function still poorly understood. The bidirectional interactions between microbiotas endocrine systems need be clarified. Probiotics prebiotics believed benefit health via a variety mechanisms, particular, tumor inhibition. It is largely unknown agents cause progresses. expect this review may open new perspectives on possible therapeutic approaches patients with cancer.
Language: Английский
Citations
28
Advanced Science, Journal Year: 2023, Volume and Issue: 10(25)
Published: July 3, 2023
Abstract Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes such sexual dimorphism in CRC from perspective sex‐biased gut microbiota metabolites. The results show that tumorigenesis is observed both Apc Min/ + mice azoxymethane (AOM)/dextran sulfate sodium (DSS)‐treated with male have significantly larger more tumors, accompanied by impaired barrier function. Moreover, pseudo‐germ receiving fecal samples or patients severe intestinal damage level inflammation. A significant change composition found increased pathogenic bacteria Akkermansia muciniphila deplets probiotic Parabacteroides goldsteinii sample mice. Sex‐biased metabolites contribute sex through glycerophospholipids metabolism pathway. Sexual mouse models. In conclusion, microbiome CRC. Modulating could be a sex‐targeting therapeutic strategy
Language: Английский
Citations
23
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 13
Published: Feb. 1, 2024
Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists growing body evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting formidable menace health human population. The perturbations microbiota may have noteworthy influence advancement cancers; however, precise mechanisms behind this association are still not comprehensively understood. Some bacteria been observed support development, while others seem provide safeguard against it. Recent studies indicated alterations composition abundance microbiomes could be associated with progression various cancers, such as colorectal, gastric, hepatic, esophageal cancers. Within comprehensive analysis, we examine significance microbiomes, particularly those located intestines, Furthermore, explore impact treatment modalities for cancer, including chemotherapy, immunotherapy, radiotherapy. Additionally, delve into intricate through which intestinal microbes efficacy treatments.
Language: Английский
Citations
13
Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(7), P. 1644 - 1654
Published: June 21, 2024
Language: Английский
Citations
11