Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury DOI Creative Commons
H Wang,

Zhaojie Su,

Yunyun Qian

et al.

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Dec. 12, 2024

Abstract The liver plays a crucial role in the immune response during endotoxemia and is one of critical targets for sepsis-related injuries. As secretory factor involved inflammation, pentraxin-3 (PTX3) has been demonstrated to regulate hepatic homeostasis; however, relationship between PTX3 cell crosstalk cells hepatocytes remains incompletely understood. In this study, we revealed that, compared with WT mice, Ptx3 −/− mice lipopolysaccharide (LPS)-induced exhibited alleviated damage, reduced serum alanine transaminase aspartate levels an improved survival rate. Mechanistically, RNA-Seq western blot results that knockdown increased expression Tfrc Ccl20 ; consequently, deficiency regulated LPS-induced hepatocyte ferroptosis via mitochondrial reactive oxygen species Fe 2+ recruited more macrophages by CCL20/CCR6 axis be inflammation clearance harmful substances. Moreover, immunofluorescence staining confirmed NF-κB signaling pathway was upregulated upon LPS treatment -knockdown macrophages, promoting phagocytosis polarization toward M1 macrophages. Collectively, our findings show absence can ameliorate sepsis-induced injury regulating promote recruitment These offer key basis development effective treatments acute infections.

Language: Английский

Activation of the α7nAChR by GTS-21 mitigates septic tubular cell injury and modulates macrophage infiltration DOI
Aobing Yang, Chia-Hsien Wu,

S. Matsuo

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112555 - 112555

Published: June 28, 2024

Language: Английский

Citations

3
Spotlight on pro-inflammatory chemokines: regulators of cellular communication in cognitive impairment DOI Creative Commons

Chenxu Wang,

Jia‐Yi Wang, Zhichao Zhu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 1, 2024

Cognitive impairment is a decline in people's ability to think, learn, and remember, so forth. global health challenge that affects the quality of life thousands people. The condition covers wide range from mild cognitive severe dementia, which includes Alzheimer's disease (AD) Parkinson's (PD), among others. While etiology diverse, role chemokines increasingly evident, especially presence chronic inflammation neuroinflammation. Although inflammatory have been linked impairment, usually multifactorial. Researchers are exploring other mediators dysfunction trying develop therapeutic strategies mitigate their effects. pathogenesis disorders very complex, underlying causative mechanisms not clarified, treatment always one challenges field medicine. Therefore, its has important socioeconomic value. Chemokines growing family structurally functionally related small (8-10 kDa) proteins, there evidence pro-inflammatory associated with many neurobiological processes may be relevant neurological beyond classical chemotactic function play crucial progression disorders. In this paper, we review roles regulatory (CCL2, CCL3, CCL4, CCL5, CCL11, CCL20, CXCL8) impairment. We also discuss intrinsic relationship between two, hoping provide some valuable references for

Language: Английский

Citations

3
Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer DOI Creative Commons

Hui Shan,

Guangyu Tian,

Yeqing Zhang

et al.

Cancer Biology & Therapy, Journal Year: 2024, Volume and Issue: 25(1)

Published: Aug. 20, 2024

Colorectal Cancer (CRC) is the third most common cancer worldwide, and occurrence development of CRC are influenced by molecular biology characteristics CRC, especially alterations in key signaling pathways. The transforming growth factor-β (TGF-β) plays a crucial role cellular growth, differentiation, migration, apoptosis, with SMAD4 protein serving as transcription factor TGF-β pathway, thus playing significant onset progression CRC. one malignancies high mortality rate worldwide. Despite research progress recent years, regarding SMAD4, its dual early late stages tumor has promoted further discussion on complexity therapeutic target, highlighting urgent need for deeper analysis This review aims to explore function potential target.

Language: Английский

Citations

3
Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases DOI Creative Commons
Ying Wang, Ningning Xue, Ziyuan Wang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 26, 2023

With the improved quality of life, oral health is under increased pressure. Numerous common mucosal diseases, such as lichen planus(OLP) and gingivitis, are related to destruction immune barrier. The cytokines secreted by T-helper 17 (Th17) cells essential for maintaining homeostasis play roles in surveillance. When antigens stimulate epithelium, Th17 expand, differentiate, generate inflammatory factors recruit other lymphocytes, neutrophils, clear infection, which helps maintain integrity epithelial In contrast, excessive Th17/IL-17 axis reactions may cause autoimmune damage. Therefore, an in-depth understanding role mucosa provide prospects treating diseases. We reviewed various skin systemic diseases with characteristics, based on findings these reports, we emphasize that cellular response be a critical factor mucosa. addition, should pay attention relationship “pathogenic Th17” “non-pathogenic hope reference potential therapeutic target disorders future.

Language: Английский

Citations

9
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma DOI Creative Commons
Jing Yang, James S. Lewis,

Jinghuan Zi

et al.

The Journal of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

SMAD4 is a tumor suppressor mutated or silenced in multiple cancers, including oral cavity squamous cell carcinoma (OSCC). Human clinical samples and lines, mouse models organoid culture were used to investigate the role that plays progression from benign disease invasive OSCC. OSCC lost detectable protein within epithelium 24% of cases, this loss correlated with worse progression-free survival independent other major pathological features. A model engineered for Kras

Language: Английский

Citations

2
Progress of CCL20-CCR6 in the airways: a promising new therapeutic target DOI Creative Commons
Yang Li, Wenjing Geng, Chen-chen Li

et al.

Journal of Inflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 27, 2024

The chemokine CCL20, a small cytokine that belongs to the C–C family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According current research, CCL20-CCR6 has been established as acritical player in diverse inflammatory, oncogenic, and autoimmune diseases. Within respiratory system, demonstrates heightened expression conditions such allergic asthma, chronic airway inflammation, non-small lung cancer (NSCLC), obstructive pulmonary disease (COPD), other diseases, conducive inflammatory mediators recruitment tumor microenvironment remodeling. Numerous studies have demonstrated therapeutic interventions targeting CCL20 including antibodies antagonists, potential mitigate progression. Despite promising research prospects surrounding axis, precise mechanisms underlying action diseases remain largely elusive. In this review, we delve into roles axis within system by synthesizing analyzing findings. Our objective provide comprehensive understanding implications for health disease. And aspire propel endeavors domain furnish valuable insights development future strategies.

Language: Английский

Citations

2
Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers DOI

Jirui Wen,

Ling Wang, Juan Cheng

et al.

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(3)

Published: Feb. 1, 2024

Abstract Occupational exposure to extreme high temperatures and the increasing global necessitates a deeper understanding of impact heat on human health. However, molecular mechanisms underlying response monocytes neutrophils in occupational population remain be fully elucidated. This study used longitudinal transcriptome assess acute (50°C for 30 min) 10 subjects from mine rescue team before (baseline) at 5 min, 1 h, 24 h after (recovery). The time‐series analysis revealed coordinated choreography changes involving inflammation, coagulation, extracellular matrix, energy metabolism. Importantly, characterized inflammatory signature associated with neutrophils, as evidenced by rapid activation inflammation‐related following exposure. Additionally, we pinpointed potential regulators, such NR4A1, FOSL1, EGR3, ATF3. In summary, suggested that initial stress member was primarily pro‐inflammatory response, which could potentially lead development inflammation ultimately result systemic heatstroke.

Language: Английский

Citations

1
Analyzing the Functional Roles and Immunological Features of Chemokines in COAD DOI Open Access
Houxi Xu, Yihua Song

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5410 - 5410

Published: May 15, 2024

Chemokines are key proteins that regulate cell migration and immune responses essential for modulating the tumor microenvironment. Despite their close association with colon cancer, expression patterns, prognosis, immunity, specific roles of chemokines in cancer still not fully understood. In this study, we investigated mutational features, differential expression, immunological characteristics (COAD) by analyzing Tumor Genome Atlas (TCGA) database. We clarified biological functions these using Gene Ontology (GO) annotation Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis. By univariate multivariate COX regression analyses, developed chemokine-based prognostic risk models. addition, Set Enrichment Analysis (GSEA) Variant (GSVA), analyzed differences signaling pathways among different groups. The results showed mutation rate was low COAD, but 25 were significantly differentially expressed. These function several immune-related processes play including cytokine–cytokine receptor interactions, NF-kappa B, IL-17. Prognostic models based on CCL22, CXCL1, CXCL8, CXCL9, CXCL11 performed well. GSEA GSVA analyses significant across conclusion, study reveals potential molecular mechanisms COAD proposes a new model insights.

Language: Английский

Citations

1
The role of inflammatory proteins in regulating the impact of lipid specifications on deep venous thrombosis: a two sample and mediated Mendelian randomization study DOI Creative Commons
Fan Dong,

Jiahao Sun,

Yudong Zhang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 20, 2024

To investigate the potential mediating role of inflammatory proteins in association between lipid species and Deep Venous Thrombosis (DVT).

Language: Английский

Citations

1
Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway DOI Creative Commons
Xingyu Rao, Hong Luo,

Kaiyuan Luo

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 6, 2024

The TGF-β/SMAD signaling pathway is crucial in the pathogenesis of asthma. However, SMAD family member 4 (SMAD4), a key mediator TGF-β, its roles and underlying mechanisms asthma remain unclear. vivo vitro SMAD4 were investigated through an ovalbumin (OVA)-induced mouse model interleukin-13 (IL-13)-induced cell model. molecular mechanism influenced was examined using transcriptome sequencing, followed by feedback experiments involving recombinant human interleukin 17 A (rhIL-17 A), IL-17 activator. highly expressed models. silencing alleviated damage to lung tissue decreased inflammatory infiltration. Expression levels Caspase-3, IgG, factors reduced after SMAD4. Silencing suppressed ferroptosis. also enhanced IL-13-induced BEAS-2B proliferation apoptosis. Furthermore. promoted models, as evidenced elevated IL-17RA, A, Act1 protein levels. inhibited expression these pathway-associated proteins. Moreover, rhIL-17 treatment notably reversed impacts on OVA-induced model, indicating that inflammation ferroptosis blocking pathway. prevents inhibiting pathway, which provides novel potential approach for therapy.

Language: Английский

Citations

1