Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

Nutrients, Journal Year: 2022, Volume and Issue: 15(1), P. 184 - 184

Published: Dec. 30, 2022

Diabetic kidney disease (DKD) occurs in 25–40% of patients with diabetes. Individuals DKD are at a significant risk progression to end-stage morbidity and mortality. At present, although renal function-decline can be retarded by intensive glucose lowering strict blood pressure control, these current treatments have shown no beneficial impact on preventing failure. Recently, addition control sugar pressure, dietary approach has been recommended for management DKD. Amino acids (AAs) both biomarkers causal factors progression. AA homeostasis contributes hemodynamic response glomerular hyperfiltration alteration diabetic patients. This review discusses the links between progressive dysfunction metabolic histidine, tryptophan, methionine, glutamine, tyrosine, branched-chain AAs. In addition, we emphasize regulation effects special metabolites progression, focus causality potential mechanisms. paper may offer an optimized protein diet strategy concomitant reduce risks setting hyperglycemia.

Language: Английский

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The contribution of gut-brain axis to development of neurological symptoms in COVID-19 recovered patients: A hypothesis and review of literature

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 22, 2022

The gut microbiota undergoes significant alterations in response to viral infections, particularly the novel SARS-CoV-2. As impaired can trigger numerous neurological disorders, we suggest that long-term symptoms of COVID-19 may be related intestinal disorders these patients. Thus, have gathered available information on how virus affect gastrointestinal systems, both acute and recovery phase disease, described several mechanisms through which this dysbiosis lead such as Guillain-Barre syndrome, chronic fatigue, psychiatric depression anxiety, even neurodegenerative diseases Alzheimer’s Parkinson’s disease. These mediated by inflammatory cytokines, well certain chemicals hormones (e.g., CCK), neurotransmitters 5-HT), etc. short-chain fatty acids), autonomic nervous system. In addition direct influences virus, repurposed medications used for patients also play a role dysbiosis. conclusion, although there are many dark spots our current knowledge mechanism COVID-19-related gut-brain axis disturbance, based evidence, hypothesize two phenomena more than just coincidence highly recommend large-scale epidemiologic studies future.

Language: Английский

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Association between microbiota and immune response to Sars-CoV-2 infection

Infectious Diseases Now, Journal Year: 2023, Volume and Issue: 53(4), P. 104646 - 104646

Published: Jan. 13, 2023

Language: Английский

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Exploring gut–lung axis crosstalk in SARS‐CoV‐2 infection: Insights from a hACE2 mouse model

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(1)

Published: Jan. 1, 2024

Abstract Based on the forefront of clinical research, there is a growing recognition that gut microbiota, which plays pivotal role in shaping both innate and adaptive immune systems, may significantly contribute to pathogenesis coronavirus disease 2019 (COVID‐19). Although an association between altered microbiota COVID‐19 has been established, causative mechanisms remain incompletely understood. Additionally, validation precise functional alterations within relevant limited by scarcity suitable animal experimental models. In present investigation, we employed newly developed humanized ACE2 knock‐in (hACE2‐KI) mouse model, capable recapitulating critical aspects pulmonary intestinal infection, explore modifications following severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection. Examination fecal samples using 16S rRNA gene profiling unveiled notable reduction species richness conspicuous composition at 6 days postinfection (dpi). These were primarily characterized decline beneficial bacterial escalation certain opportunistic pathogens. Moreover, our analysis entailed correlation study plasma cytokine concentrations, revealing potential involvement Lachnospiraceae_NK4A136_ group unclassified_f_Lachnospiraceae genera attenuating hyperinflammatory responses triggered Furthermore, integration data with RNA‐seq results suggested increased presence Staphylococcus signify for coinfection lung tissues via translocation. summary, hACE2‐KI model effectively recapitulated observed during SARS‐CoV‐2 This presents valuable tool elucidating microbiota‐targeted strategies aimed mitigating COVID‐19.

Language: Английский

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Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Integrative Medicine in Nephrology and Andrology, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 30, 2024

ABSTRACT Background: The gut microbiota is closely associated with chronic kidney disease (CKD) development and prognosis. However, a comprehensive understanding of publication trends research focuses within this domain remains limited. This study aimed to elucidate the relationship between CKD through bibliometric analysis. Methods: Literature published 2001 2022 on was obtained from Web Science Core Collection database. Bibliometric analysis tools such as VOSviewer CiteSpace were used analyze in area. Results: We extracted 758 articles for further China ranked first 240 documents, followed by USA 211. regarding citation frequency 11,380 citations, while second. University California Irvine Kidney International emerged leading institution journal, respectively, former document production citations. Although featured fewer documents than other journals, it exhibited highest count. keywords representing interests mainly included: (1) influences CKD, (2) application probiotics treatment (3) potential mechanism CKD. Conclusion: Our indicates significant advancements association It also provides overview trends, hotspots, frontiers, which may provide guidelines future research.

Language: Английский

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