Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155521 - 155521
Published: March 8, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113005 - 113005
Published: April 25, 2022
Ligusticum chuanxiong Hort (known as Chuanxiong in China, CX) is one of the most widely used and long-standing medicinal herbs China. Tetramethylpyrazine (TMP) an alkaloid active components CX. Over past few decades, TMP has been proven to possess several pharmacological properties. It treat a variety diseases with excellent therapeutic effects. Here, characteristics molecular mechanism recent years are reviewed, emphasis on signal-regulation TMP. This review shows that many physiological functions, including anti-oxidant, anti-inflammatory, anti-apoptosis properties; autophagy regulation; vasodilation; angiogenesis mitochondrial damage suppression; endothelial protection; reduction proliferation migration vascular smooth muscle cells; neuroprotection. At present, treating cardiovascular, nervous, digestive system conditions, cancer, other conditions achieved good curative The involves multiple targets, pathways, bidirectional regulation. is, thus, promising drug great research potential.
Language: Английский
Citations
127
Phytomedicine, Journal Year: 2023, Volume and Issue: 122, P. 155135 - 155135
Published: Oct. 12, 2023
Language: Английский
Citations
83
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 17, 2023
Diabetic foot ulcer (DFU) is a major complication of diabetes and associated with high risk lower limb amputation mortality. During their lifetime, 19%–34% patients can develop DFU. It estimated that 61% DFU become infected 15% those require amputation. Furthermore, developing increases the mortality by 50%–68% at 5 years, higher than some cancers. Current standard management includes surgical debridement, use topical dressings wound decompression, vascular assessment, glycemic control. Among these methods, local treatment builds protective physical barrier, maintains moist environment, drains exudate from wounds. This review summarizes development, pathophysiology, healing mechanisms The latest research progress main application in laboratory clinical stage are also summarized. discussed this include traditional (gauze, oil yarn, Chinese medicine, others), basic (hydrogel, hydrocolloid, sponge, foam, film agents, bacteriostatic dressings, composite (collagen, nanomaterials, chitosan bioactive (scaffold stem cells, decellularized matrix, autologous platelet enrichment plasma, modern technology (3D bioprinting, photothermal effects, bioelectric microneedle smart bandages, orthopedic prosthetics regenerative medicine). dressing challenges limitations purpose to help readers understand pathogenesis mechanism DFU, physicians select correctly, provide an updated overview potential biomaterials devices management, ideas for further exploration development dressings. Proper promote healing, reduce cost treating patient pain.
Language: Английский
Citations
55
World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(29), P. 3511 - 3533
Published: July 28, 2024
(CB), used in traditional Chinese medicine, exhibits anti-tumor effects various cancer models. It also constitutes an integral component of a compound formulation known as Pien Tze Huang, which is indicated for the treatment liver cancer. However, its impact on tumor microenvironment, particularly tumor-associated macrophages (TAMs), not well understood.
Language: Английский
Citations
23
Chinese Medicine, Journal Year: 2021, Volume and Issue: 16(1)
Published: Dec. 1, 2021
Abstract The high incidence of breast cancer is the greastest threat to women’ health all over world. Among them, HER-2 positive has characteristics malignancy, easy recurrence and metastasis, poor prognosis. Traditional Chinese medicine (TCM) a rich theoretical basis clinical application for cancer. TCM believes that blood stasis syndrome one important pathogenesis formation development. Taohong Siwu Decoction (TSHWD) based on “First Prescription Gynecology” Decoction. It widely used in various deficiency syndromes, mainly gynecological stasis. Clinical studies have found THSWD can treat by reducing vessel lymphangiogenesis with auxiliary chemotherapy. In this study, we aim explore material mechanism treatment through literature review network pharmacology studies. Through traditional application, chemical composition herbal THSWD, as well its reports pharmacological research treatment. Meanwhile, conducted “component-pathway-target” reveals main basis, possible targets pathways inhibiting Literature results had predicted that, baicalein, kaempferol, caffeic acid, amygdalin, quercetin, ferulic gallic catalpol, hydroxysafflor yellow A, paeoniflorin are effective composition. regulates 386 protein 166 related molecular improve microenvironment tumor cells, regulate process cell EMT, inhibit proliferation metastasis. This study revealed action studies, providing scientific application.
Language: Английский
Citations
63
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 10, 2022
With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.
Language: Английский
Citations
40
Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(5), P. 1778 - 1808
Published: May 14, 2023
Abstract The antitumor efficacy of Chinese herbal medicines has been widely recognized. Leading compounds such as sterols, glycosides, flavonoids, alkaloids, terpenoids, phenylpropanoids, and polyketides constitute their complex active components. monomers derived from medicine possess an attractive anticancer activity. However, use was limited by low bioavailability, significant toxicity, side effects, hindering clinical applications. Recently, new chemical entities have designed synthesized combining natural drugs with other small drug molecules or moieties to improve the activity selectivity, reduce effects. Such a novel conjugated that can interact several vital biological targets in cells may more synergistic than single‐molecule drug. In addition, conjugates could be obtained pharmacophores containing two known leading compounds. Based on these studies, research development greatly shortened. This study reviews progress based medicine. It is expected serve valuable reference application traditional
Language: Английский
Citations
40
Applied Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 107(14), P. 4471 - 4492
Published: June 5, 2023
Language: Английский
Citations
28
Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117323 - 117323
Published: Oct. 16, 2023
The Qi-Qin-Hu-Chang Formula (QQHCF) is a traditional Chinese medicine prescription that clinically used at the Affiliated Hospital of Nanjing University Medicine for treatment colitis-associated colorectal cancer (CAC).
Language: Английский
Citations
24
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155523 - 155523
Published: March 9, 2024
Language: Английский
Citations
14