Annals of the Rheumatic Diseases,
Journal Year:
2023,
Volume and Issue:
83(1), P. 72 - 87
Published: Sept. 29, 2023
Objectives
To
investigate
the
effect
of
L-arginine
metabolism
on
arthritis
and
inflammation-mediated
bone
loss.
Methods
was
applied
to
three
models
(collagen-induced
arthritis,
serum-induced
human
TNF
transgenic
mice).
Inflammation
assessed
clinically
histologically,
while
changes
were
quantified
by
μCT
histomorphometry.
In
vitro,
effects
osteoclast
differentiation
analysed
RNA-seq
mass
spectrometry
(MS).
Seahorse,
Single
Cell
ENergetIc
profilIng
Translation
inHibition
transmission
electron
microscopy
used
for
detecting
metabolic
in
osteoclasts.
Moreover,
arginine-associated
metabolites
measured
serum
rheumatoid
(RA)
pre-RA
patients.
Results
inhibited
loss
all
directly
blocked
TNFα-induced
murine
osteoclastogenesis.
MS
analyses
indicated
that
switched
glycolysis
oxidative
phosphorylation
inflammatory
osteoclasts
leading
increased
ATP
production,
purine
elevated
inosine
hypoxanthine
levels.
Adenosine
deaminase
inhibitors
blocking
production
abolished
inhibition
osteoclastogenesis
vitro
vivo.
Altered
arginine
levels
also
found
RA
Conclusion
Our
study
demonstrated
ameliorates
erosion
through
reprogramming
perturbation
Nature Immunology,
Journal Year:
2023,
Volume and Issue:
24(9), P. 1540 - 1551
Published: Aug. 10, 2023
Circulating
proteins
have
important
functions
in
inflammation
and
a
broad
range
of
diseases.
To
identify
genetic
influences
on
inflammation-related
proteins,
we
conducted
genome-wide
protein
quantitative
trait
locus
(pQTL)
study
91
plasma
measured
using
the
Olink
Target
platform
14,824
participants.
We
identified
180
pQTLs
(59
cis,
121
trans).
Integration
pQTL
data
with
eQTL
disease
association
studies
provided
insight
into
pathogenesis,
implicating
lymphotoxin-α
multiple
sclerosis.
Using
Mendelian
randomization
(MR)
to
assess
causality
etiology,
both
shared
distinct
effects
specific
across
immune-mediated
diseases,
including
directionally
discordant
CD40
risk
rheumatoid
arthritis
versus
sclerosis
inflammatory
bowel
disease.
MR
implicated
CXCL5
etiology
ulcerative
colitis
(UC)
show
elevated
gut
transcript
expression
patients
UC.
These
results
targets
existing
drugs
provide
powerful
resource
facilitate
future
drug
target
prioritization.
EClinicalMedicine,
Journal Year:
2023,
Volume and Issue:
64, P. 102193 - 102193
Published: Sept. 9, 2023
The
causes
for
immune-mediated
inflammatory
diseases
(IMIDs)
are
diverse
and
the
incidence
trends
of
IMIDs
from
specific
rarely
studied.
study
aims
to
investigate
pattern
trend
1990
2019.We
collected
detailed
information
on
six
major
IMIDs,
including
asthma,
bowel
disease,
multiple
sclerosis,
rheumatoid
arthritis,
psoriasis,
atopic
dermatitis,
between
2019,
derived
Global
Burden
Disease
in
2019.
average
annual
percent
change
(AAPC)
number
incidents
age
standardized
rate
(ASR)
by
sex,
age,
region,
causes,
were
calculated
quantify
temporal
trends.In
disease
accounted
1.59%,
36.17%,
54.71%,
0.09%,
6.84%,
0.60%
overall
new
cases,
respectively.
ASR
showed
substantial
regional
global
variation
with
highest
High
SDI
High-income
North
America,
United
States
America.
Throughout
human
lifespan,
distribution
incident
cases
was
quite
different.
Globally,
increased
an
AAPC
0.68
decreased
-0.34
across
arthritis
(0.21,
95%
CI
0.18,
0.25),
while
asthma
(AAPC
=
-0.41),
-0.72),
sclerosis
-0.26),
psoriasis
-0.77),
dermatitis
-0.15)
decreased.
individual
IMID
at
level.
Countries
higher
experienced
a
more
rapid
decrease
ASR.The
patterns
varied
considerably
world.
Innovative
prevention
integrative
management
strategy
urgently
needed
mitigate
increasing
upsurging
other
five
respectively.The
Study
is
funded
Bill
Melinda
Gates
Foundation.
project
Scientific
Research
Fund
Sichuan
Academy
Medical
Sciences
&
Provincial
People's
Hospital
(2022QN38).
Polymers,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2373 - 2373
Published: May 19, 2023
The
prevention
of
disease
and
infection
requires
immune
systems
that
operate
effectively.
This
is
accomplished
by
the
elimination
infections
abnormal
cells.
Immune
or
biological
therapy
treats
either
stimulating
inhibiting
system,
dependent
upon
circumstances.
In
plants,
animals,
microbes,
polysaccharides
are
abundant
biomacromolecules.
Due
to
intricacy
their
structure,
may
interact
with
impact
response;
hence,
they
play
a
crucial
role
in
treatment
several
human
illnesses.
There
an
urgent
need
for
identification
natural
biomolecules
prevent
treat
chronic
disease.
article
addresses
some
naturally
occurring
known
therapeutic
potential
have
already
been
identified.
also
discusses
extraction
methods
immunological
modulatory
capabilities.
JACC Basic to Translational Science,
Journal Year:
2023,
Volume and Issue:
8(6), P. 728 - 750
Published: Feb. 15, 2023
Inflammatory
activation
is
increasingly
recognized
as
a
nonconventional
risk
factor
for
arrhythmias,
and
experimental
studies
provided
robust
evidence
that
this
association
mediated
by
direct
arrhythmogenic
effects
of
proinflammatory
cytokines
on
cardiac
cells.
Additionally,
inflammatory
can
favor
arrhythmias
indirectly
through
multiple
systemic
effects.
Accumulating
data
confirm
the
clinical
relevance
these
mechanisms;
largest
being
available
atrial
fibrillation,
acquired
long-QT
syndrome,
ventricular
arrhythmias.
However,
management
largely
neglects
cytokines.
This
review
integrates
basic
science
research
to
present
an
updated
overview
topic
provides
future
directions
patient's
management.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1629 - 1629
Published: March 6, 2023
Immune-checkpoint
inhibitors
(ICIs)
are
antagonists
of
inhibitory
receptors
in
the
immune
system,
such
as
cytotoxic
T-lymphocyte-associated
antigen-4,
programmed
cell
death
protein-1
and
its
ligand
PD-L1,
they
increasingly
used
cancer
treatment.
By
blocking
certain
suppressive
pathways,
ICIs
promote
T-cell
activation
antitumor
activity
but
may
induce
so-called
immune-related
adverse
events
(irAEs),
which
mimic
traditional
autoimmune
disorders.
With
approval
more
ICIs,
irAE
prediction
has
become
a
key
factor
improving
patient
survival
quality
life.
Several
biomarkers
have
been
described
potential
predictors,
some
them
already
available
for
clinical
use
others
under
development;
examples
include
circulating
blood
counts
ratios,
expansion
diversification,
cytokines,
autoantibodies
autoantigens,
serum
other
biological
fluid
proteins,
human
leucocyte
antigen
genotypes,
genetic
variations
gene
profiles,
microRNAs,
gastrointestinal
microbiome.
Nevertheless,
it
is
difficult
to
generalize
application
based
on
current
evidence
because
most
studies
retrospective,
time-limited
restricted
specific
type
cancer,
or
ICI.
Long-term
prospective
cohorts
real-life
needed
assess
predictive
capacity
different
biomarkers,
regardless
ICI
type,
organ
involved
site.
