Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(9), P. 105078 - 105078
Published: June 17, 2023
Diabetes
mellitus
is
a
syndrome
that
caused
due
to
the
imbalance
of
insulin
production
in
body.
In
present
study
we
have
synthesized
class
fifteen
compounds
(1–15)
based
on
thiadiazole-bearing
thiourea
were
assessed
for
vitro
alpha-amylase
and
alpha-glucosidase
inhibitory
potentials
against
standard
drug
acarbose.
this
series,
all
scaffolds
recognized
as
inhibitors
both
targeted
enzymes,
α-amylase
having
varied
range
from
IC50
values
=
35.70
±
0.70
µM
1.30
0.05
acarbose
(10.30
0.20
µM)
while
α-glucosidase
37.60
0.80
2.20
0.10
(9.80
µM).
Among
nine
such
4,
6,
7,
9,
8,
11,
12,
14
15
showed
excellent
activity
a-amylase
a-glucosidase
found
many
folds
more
potent
than
drugs
change
nature
number/s
substituent
along
entire
skeleton.
A
molecular
docking
was
conducted
active
understand
binding
modes
synthetic
analogs
how
they
show
interaction
with
part
enzymes.
To
confirm
structure
different
spectroscopic
techniques
will
be
used
like
NMR
HREI-MS.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(21), P. 16110 - 16293
Published: Sept. 16, 2022
In
the
present
review,
we
discuss
recent
progress
in
field
of
C–Z
bond
formation
reactions
(Z
=
S,
Se,
Te)
catalyzed
by
transition
metals.
Two
complementary
methodologies
are
considered─catalytic
cross-coupling
and
catalytic
addition
reactions.
The
development
advanced
systems
is
aimed
at
improved
catalyst
efficiency,
reduced
loading,
better
cost
environmental
concerns,
higher
selectivity
yields.
important
rise
research
efforts
sustainability
green
chemistry
areas
critically
assessed.
paramount
role
mechanistic
studies
a
new
generation
addressed,
key
achievements,
problems,
challenges
summarized
for
this
field.
Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(7), P. RCR5125 - RCR5125
Published: July 1, 2024
The
chemistry
of
heterocyclic
compounds
has
traditionally
been
and
remains
a
bright
area
chemical
science
in
Russia.
This
is
due
to
the
fact
that
many
heterocycles
find
widest
application.
These
are
key
structural
fragments
most
drugs,
plant
protection
agents.
Many
natural
also
derivatives
heterocycles.
At
present,
more
than
half
hundreds
millions
known
collective
review
devoted
achievements
Russian
chemists
this
field
over
last
15–20
years.
presents
leading
heterocyclists
representing
both
RAS
institutes
university
science.
It
worth
noting
wide
scope
review,
terms
geography
author
teams,
covering
whole
our
large
country,
diversity
research
areas.
Practically
all
major
types
represented
review.
special
attention
focused
on
practical
applications
design
new
drugs
biologically
active
compounds,
high-energy
molecules,
materials
for
organic
electronics
photovoltaics,
ligands
coordination
chemistry,
other
rapidly
developing
advances
would
not
be
possible
without
development
fundamental
transformations
chemistry.<br>
Bibliography
—
2237
references.
Journal of Heterocyclic Chemistry,
Journal Year:
2022,
Volume and Issue:
60(4), P. 537 - 565
Published: Oct. 13, 2022
Abstract
Among
different
heterocyclic
compounds,
isoxazole
and
their
analogues
are
very
important
classes
of
compounds
as
they
display
an
extensive
range
biological
actions.
This
makes
such
scaffolds
structures
in
the
field
medicinal
chemistry.
From
literature
assessment,
is
clinically
proven
to
be
effective
anti‐bacterial,
anti‐fungal,
anti‐inflammatory,
anti‐cancer,
anti‐tubercular,
anti‐neoplastic
agent.
The
derivatives
which
exhibits
adjustment
structure
have
shown
a
high
degree
variety
properties
evident
them
beneficial
progress
novel
bioactive
drugs
show
enhanced
effectiveness
along
with
minor
harmfulness.
Structural
aspects
having
aromaticity
weaker
nitrogen‐oxygen
bonding
provide
potential
site
for
ring
cleavage.
Thus,
this
system
allows
easier
modifications
substituents
consequently
make
useful
intermediates
various
synthetic
routes
compounds.
Hence,
synthesis
evaluation
isoxazole‐containing
molecules
wider
therapeutic
consequences
always
topic
interest
chemists.
light
comprehensive
research
on
isoxazole,
it
thought
worthwhile
review
pathways
broad
spectrum
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(8), P. 3111 - 3116
Published: Jan. 1, 2023
A
general
visible
light-promoted
and
electron–donor–acceptor
complex-enabled
cascade
reaction
of
alkynes
to
produce
functionalized
sulfur-containing
heterocycles
under
photocatalyst-,
base-,
oxidant-
metal-free
conditions
was
developed.
The Open Medicinal Chemistry Journal,
Journal Year:
2020,
Volume and Issue:
14(1), P. 49 - 64
Published: Sept. 14, 2020
Nitrogen
sulphur
containing
heterocycles
have
specific
properties
due
to
which
they
can
be
used
as
a
potential
material
in
different
type
of
industries
such
medicinal/pharmaceutical,
paint,
packing
and
textile,
required
for
various
chemical,
physical
operations
their
use
products.
Especially
dyes,
agrochemicals,
medicine,
etc
.
make
them
more
significant.
In
present
days,
Nitrogen-Sulfur
are
repeatedly
attracting
the
interest
chemists
exceptional
bioactive
behavior.
The
study
is
review
work
carried
out
by
chemist
discovery
new,
effective,
medicinally
important
heterocyclic
compounds.
basically
focused
on
nitrogen-sulfur
therapeutic
interest,
especially
with
thiazole,
thiazine,
pyrimidine,
morpholine
piperazine
heterosystems,
benzothiazines,
pyrazole-benzothiazines,
morpholine-benzothiazines,
piperazine-benzothiazines
pyrimidine-benzothiazoles,
mainly
unique
structural
features,
enable
exhibit
number
biological
pharmacological
activities.
Due
novel
mode
action,
broad
spectrum
activity,
lesser
toxicity
towards
mammalian
cells,
suitable
profiles
humans
triggered
Sulphur
designing
synthesizing
derivatives
better
properties.
overall
objective
discuss
importance
biodynamic
structurally
diverse
interest:
morpholine,
piperazine,
pyrozole,
benothiazoles,
pyrimidobenzothiazoles,
4H-1,4-benzothiazines,
pyrazolyl-benzothiazines,
morpholinyl-benzothiazines
piperazinylbenzothiazines
order
access
commercial
molecules
search
future.
Journal of Medicinal Chemistry,
Journal Year:
2021,
Volume and Issue:
64(4), P. 1786 - 1815
Published: Feb. 11, 2021
Incorporation
of
heterocycles
into
drug
molecules
can
enhance
physical
properties
and
biological
activity.
A
variety
heterocyclic
groups
is
available
to
medicinal
chemists,
many
which
have
been
reviewed
in
detail
elsewhere.
Oxadiazoles
are
a
class
heterocycle
containing
one
oxygen
two
nitrogen
atoms,
three
isomeric
forms.
While
the
1,2,4-
1,3,4-oxadiazoles
seen
widespread
application
chemistry,
1,2,5-oxadiazoles
(furazans)
less
common.
This
Review
provides
summary
furazan-containing
chemistry
development
programs
from
analysis
both
patent
academic
literature.
Emphasis
placed
on
that
reached
clinical
or
preclinical
stages
development.
The
examples
provided
herein
describe
pharmacology
activity
furazan
derivatives
with
comparative
data
where
possible
for
other
pharmacophores
commonly
used
chemistry.
