Parsing Molecular and Behavioral Effects of Cocaine in Mitogen- and Stress-Activated Protein Kinase-1-Deficient Mice DOI Creative Commons
Karen Brami‐Cherrier, Emmanuel Valjent, Denis Hervé

et al.

Journal of Neuroscience, Journal Year: 2005, Volume and Issue: 25(49), P. 11444 - 11454

Published: Dec. 7, 2005

Although the induction of persistent behavioral alterations by drugs abuse requires regulation gene transcription, precise intracellular signaling pathways that are involved remain mainly unknown. Extracellular signal-regulated kinase (ERK) is critical for expression immediate-early genes in striatum response to cocaine and Δ9-tetrahydrocannabinol rewarding properties these drugs. Here we show mice a single injection (10 mg/kg) activates mitogen- stress-activated protein 1 (MSK1) dorsal nucleus accumbens. Cocaine-induced phosphorylation MSK1 threonine 581 cAMP element-binding (CREB) serine 133 (Ser ) were blocked SL327, drug prevents ERK activation. Cocaine increased acetylation histone H4 lysine 5 H3 Ser 10 , demonstrating existence drug-induced chromatin remodeling vivo . In knock-out (KO) CREB blocked, c-Fos dynorphin was prevented, whereas Egr-1 (early growth response-1)/zif268/Krox24 unaltered. MSK1-KO had no obvious neurological defect but displayed contrasted phenotype cocaine. Acute effects dopamine D or 2 agonists Sensitivity low doses, not high conditioned place preference paradigm, locomotor sensitization repeated injections decreased markedly. Our results major striatal kinase, downstream from ERK, responsible required specifically as well sensitization.

Language: Английский

The Physiology, Signaling, and Pharmacology of Dopamine Receptors DOI
Jean‐Martin Beaulieu, Raul R. Gainetdinov

Pharmacological Reviews, Journal Year: 2011, Volume and Issue: 63(1), P. 182 - 217

Published: Feb. 8, 2011

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions catecholaminergic neurotransmitter dopamine, ranging from voluntary movement reward to hormonal regulation hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in management several neurological psychiatric disorders, including Parkinson9s disease, schizophrenia, bipolar disorder, Huntington9s attention deficit hyperactivity disorder (ADHD1), Tourette9s syndrome. Numerous advances occurred understanding general structural, biochemical, functional properties that led development multiple pharmacologically active compounds directly target receptors, such as antiparkinson drugs antipsychotics. Recent progress complex biology receptor-related signal transduction mechanisms has revealed that, addition their primary action on cAMP-mediated signaling, can act through diverse signaling involve alternative protein coupling or protein-independent via interactions with ion channels proteins are characteristically implicated receptor desensitization, β-arrestins. One future directions managing dopamine-related pathologic conditions may a transition approaches affect function precise postreceptor intracellular modalities either ligand-biased pharmacology. In this comprehensive review, we discuss classification, basic structural genetic organization, distribution brain periphery, mechanisms. addition, abnormalities expression, function, documented human disorders current pharmacology emerging trends novel therapeutic at and/or related events.

Language: Английский

Citations

2484
Regulation of NMDA receptor trafficking by amyloid-β DOI
Eric M. Snyder,

Yi Nong,

Cláudia G. Almeida

et al.

Nature Neuroscience, Journal Year: 2005, Volume and Issue: 8(8), P. 1051 - 1058

Published: July 17, 2005

Language: Английский

Citations

1500
Identification and Functional Characterization of Brainstem Cannabinoid CB 2 Receptors DOI

Marja D. Van Sickle,

Marnie Duncan,

Philip J. Kingsley

et al.

Science, Journal Year: 2005, Volume and Issue: 310(5746), P. 329 - 332

Published: Oct. 13, 2005

The presence and function of CB 2 receptors in central nervous system (CNS) neurons are controversial. We report the expression receptor messenger RNA protein localization on brainstem neurons. These functional were activated by a agonist, 2-arachidonoylglycerol, elevated endogenous levels endocannabinoids, which also act at 1 receptors. represent an alternative site action endocannabinoids that opens possibility nonpsychotropic therapeutic interventions using enhanced endocannabinoid localized brain areas.

Language: Английский

Citations

1445
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types DOI Creative Commons
Myriam Heiman, Anne Schaefer, Shiaoching Gong

et al.

Cell, Journal Year: 2008, Volume and Issue: 135(4), P. 738 - 748

Published: Nov. 1, 2008

Language: Английский

Citations

1138
Molecular Mechanisms of Fear Learning and Memory DOI Creative Commons
Joshua P. Johansen, Christopher K. Cain, Linnaea Ostroff

et al.

Cell, Journal Year: 2011, Volume and Issue: 147(3), P. 509 - 524

Published: Oct. 1, 2011

Language: Английский

Citations

968
Dopamine: Functions, Signaling, and Association with Neurological Diseases DOI
Marianne Klein, Daniella S. Battagello, Ariel R. Cardoso

et al.

Cellular and Molecular Neurobiology, Journal Year: 2018, Volume and Issue: 39(1), P. 31 - 59

Published: Nov. 16, 2018

Language: Английский

Citations

804
Opposing Patterns of Signaling Activation in Dopamine D1and D2Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol DOI Creative Commons
Jesus Bertran‐Gonzalez, Clémentine Bosch‐Bouju, Matthieu Maroteaux

et al.

Journal of Neuroscience, Journal Year: 2008, Volume and Issue: 28(22), P. 5671 - 5685

Published: May 28, 2008

Psychostimulants and other drugs of abuse activate extracellular signal-regulated kinase (ERK) in the striatum, through combined stimulation dopamine D 1 receptors (D1Rs) glutamate NMDA receptors. Antipsychotic similar signaling proteins striatum by blocking 2 (D2Rs). However, neurons which these pathways are activated psychotropic not precisely identified. We used transgenic mice, enhanced green fluorescent protein (EGFP) expression was driven D1R promoter ( drd1a -EGFP) or D2R drd2 -EGFP). confirmed -EGFP striatonigral striatopallidal neurons. Drd2 also expressed cholinergic interneurons, whereas no either detected GABAergic interneurons. Acute cocaine treatment increased phosphorylation ERK its direct indirect nuclear targets, mitogen- stress-activated kinase-1 (MSK1) histone H3, exclusively D1R-expressing output dorsal nucleus accumbens. Cocaine-induced c-Fos Zif268 predominated but observed D2R-expressing One week after repeated administration, cocaine-induced responses were decreased, with exception striatum. The remained confined to In contrast, acute haloperidol injection ERK, MSK1, H3 only induced c-fos zif268 predominantly Our results demonstrate that specifically two completely segregated populations striatal neurons, providing evidence for selective mechanisms exert their long-term effects.

Language: Английский

Citations

586
Akt/GSK3 Signaling in the Action of Psychotropic Drugs DOI
Jean‐Martin Beaulieu, Raul R. Gainetdinov, Marc G. Caron

et al.

The Annual Review of Pharmacology and Toxicology, Journal Year: 2008, Volume and Issue: 49(1), P. 327 - 347

Published: Oct. 17, 2008

Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar disorder, Tourette syndrome, ADHD, and Alzheimer disease. Independent lines of research involving biochemical behavioral approaches in normal and/or genetically modified mice provide converging evidence an involvement the signaling molecules Akt glycogen synthase kinase-3 (GSK3) regulation behavior by dopamine serotonin (5-HT). These have also received attention their role actions psychoactive antidepressants, antipsychotics, lithium, other mood stabilizers. Furthermore, investigations mechanism which D2 receptors regulate Akt/GSK3 strongly support physiological relevance a new modality G protein-coupled receptor (GPCR) multifunctional scaffolding protein beta-arrestin 2. Elucidation contribution multiple pathways to action psychotropic may better biological understanding psychiatric disorders lead more efficient therapeutics.

Language: Английский

Citations

514
Dopamine Signaling in reward-related behaviors DOI Creative Commons
Ja‐Hyun Baik

Frontiers in Neural Circuits, Journal Year: 2013, Volume and Issue: 7

Published: Jan. 1, 2013

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DAmesolimbic neurotransmission have been found to modify behavioral responses various environmental stimuli associated with reward behaviors. Psychostimulants, drugs of abuse, natural rewards such as food can cause substantial synaptic modifications DA system. Recent studies using optogenetics DREADDs, together neuron-specific or circuit-specific genetic manipulations improved our understanding signaling circuit, provided a means identify neural substrates complex behaviors drug addiction eating disorders. This review focuses on role system motivation, an overview D1 D2 receptors control reward-associated

Language: Английский

Citations

467
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP DOI
John Lisman, Anthony A. Grace, Emrah Düzel

et al.

Trends in Neurosciences, Journal Year: 2011, Volume and Issue: 34(10), P. 536 - 547

Published: Aug. 18, 2011

Language: Английский

Citations

446