Transcriptional and epigenetic mechanisms of addiction

Nature reviews. Neuroscience, Journal Year: 2011, Volume and Issue: 12(11), P. 623 - 637

Published: Oct. 12, 2011

Language: Английский

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Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

Science, Journal Year: 2010, Volume and Issue: 330(6002), P. 385 - 390

Published: Oct. 14, 2010

BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs abuse. Different subpopulations projection neurons exhibit balanced but antagonistic influences on their downstream outputs behaviors. However, roles regulating reward behaviors remains unclear. Lobo et al. (p. 385 ) evaluated two subtypes neurons, those expressing dopamine D1 versus D2 receptors, cocaine reward. Deleting TrkB, receptor for brain-derived neurotrophic factor, selectively each cell type, controlling firing type using optogenetic techniques allowed confirmation that D1- D2-containing produced opposite

Language: Английский

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What does dopamine mean?

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(6), P. 787 - 793

Published: May 11, 2018

Language: Английский

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Functional Neuroanatomy of the Basal Ganglia

Cold Spring Harbor Perspectives in Medicine, Journal Year: 2012, Volume and Issue: 2(12), P. a009621 - a009621

Published: Oct. 15, 2012

The "basal ganglia" refers to a group of subcortical nuclei responsible primarily for motor control, as well other roles such learning, executive functions and behaviors, emotions. Proposed more than two decades ago, the classical basal ganglia model shows how information flows through back cortex pathways with opposing effects proper execution movement. Although much has remained, been modified amplified emergence new data. Furthermore, parallel circuits subserve engaging associative limbic territories. Disruption network forms basis several movement disorders. This article provides comprehensive account functional anatomy chemistry major pathophysiological changes underlying disorders We try answer three key questions related ganglia, follows: What are ganglia? they made of? How do work? Some insight on canonical is provided, together selection paradoxes some views over horizon in field.

Language: Английский

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Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens

Neuron, Journal Year: 2012, Volume and Issue: 76(4), P. 790 - 803

Published: Nov. 1, 2012

Language: Английский

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Addiction Circuitry in the Human Brain

The Annual Review of Pharmacology and Toxicology, Journal Year: 2011, Volume and Issue: 52(1), P. 321 - 336

Published: March 3, 2011

A major challenge in understanding substance-use disorders lies uncovering why some individuals become addicted when exposed to drugs, whereas others do not. Although genetic, developmental, and environmental factors are recognized as contributors a person's risk of becoming addicted, the neurobiological processes that underlie this vulnerability still poorly understood. Imaging studies suggest individual variations key dopamine-modulated brain circuits, including circuits involved reward, memory, executive function, motivation, contribute differences addiction vulnerability. better main affected by chronic drug use influence social stressors, developmental trajectories, genetic background on these is bound lead more effective strategies for prevention treatment disorders.

Language: Английский

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(3), P. 816 - 871

Published: June 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Language: Английский

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Epigenetic Mechanisms in Cognition

Neuron, Journal Year: 2011, Volume and Issue: 70(5), P. 813 - 829

Published: June 1, 2011

Language: Английский

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Dopamine receptors – IUPHAR Review 13

British Journal of Pharmacology, Journal Year: 2014, Volume and Issue: 172(1), P. 1 - 23

Published: Oct. 17, 2014

The variety of physiological functions controlled by dopamine in the brain and periphery is mediated D1, D2, D3, D4 D5 GPCRs. Drugs acting on receptors are significant tools for management several neuropsychiatric disorders including schizophrenia, bipolar disorder, depression Parkinson's disease. Recent investigations receptor signalling have shown that receptors, apart from their canonical action cAMP-mediated signalling, can regulate a myriad cellular responses to fine-tune expression dopamine-associated behaviours functions. Such mechanisms may involve alternate G protein coupling or non-G involving ion channels, tyrosine kinases proteins such as β-arrestins classically involved GPCR desensitization. Another level complexity growing appreciation roles played heteromers. Applications new vivo techniques significantly furthered understanding receptors. Here we provide an update current knowledge regarding complex biology, physiology pharmacology

Language: Английский

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Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(9), P. 1230 - 1232

Published: July 27, 2015

Language: Английский

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