A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(7), P. 869 - 880

Published: June 1, 2020

Language: Английский

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Natural environments and mental health

Advances in Integrative Medicine, Journal Year: 2015, Volume and Issue: 2(1), P. 5 - 12

Published: April 1, 2015

Language: Английский

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Effects of Light on Cognitive Brain Responses Depend on Circadian Phase and Sleep Homeostasis

Journal of Biological Rhythms, Journal Year: 2011, Volume and Issue: 26(3), P. 249 - 259

Published: May 31, 2011

Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct brain function as identified by neuroimaging. How the impact light varies with wavelength light, phase, sleep homeostasis, how this differs between individuals, largely unexplored area. Using functional MRI, we compared 1 minute low-intensity blue (473 nm) green (527 exposures responses to an auditory working memory task while varying phase status homeostat. Data were collected in 27 subjects genotyped for PER3 VNTR (12 5/5 15 4/4 ) whom it was previously shown that task, when conducted darkness, depend genotype. In morning after sleep, relative increased primarily ventrolateral dorsolateral prefrontal cortex intraparietal sulcus, but only individuals. By contrast, loss, left thalamofrontoparietal circuit larger extent than so evening wake maintenance zone following normal waking day, no differential effect versus observed either Comparison current results findings darkness indicates acts activating agent particularly under those circumstances which individuals jeopardized adverse high homeostatic pressure.

Language: Английский

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Neuroimaging, cognition, light and circadian rhythms

Frontiers in Systems Neuroscience, Journal Year: 2014, Volume and Issue: 8

Published: July 8, 2014

In humans, sleep and wakefulness the associated cognitive processes are regulated through interactions between homeostasis circadian system. Chronic disruption of rhythmicity is common in our society there a need for better understanding brain mechanisms regulating sleep, processes. This review summarizes recent investigations which provide first neural correlates combined influence on activity. Markers interindividual variations sleep-wake regulation, such as chronotype polymorphisms clock genes, with changes responses subcortical cortical areas response to manipulations cycle. also includes data showing that activity by light, powerful modulator cognition alertness directly impacts rhythmicity. The effect light varied age, psychiatric status, PERIOD3 genotype phase. These new insights into contribution demographic characteristics, cycle, functioning.

Language: Английский

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Blue Light Stimulates Cognitive Brain Activity in Visually Blind Individuals

Journal of Cognitive Neuroscience, Journal Year: 2013, Volume and Issue: 25(12), P. 2072 - 2085

Published: July 16, 2013

Abstract Light regulates multiple non-image-forming (or nonvisual) circadian, neuroendocrine, and neurobehavioral functions, via outputs from intrinsically photosensitive retinal ganglion cells (ipRGCs). Exposure to light directly enhances alertness performance, so is an important regulator of wakefulness cognition. The roles rods, cones, ipRGCs in the impact on cognitive brain functions remain unclear, however. A small percentage blind individuals retain photoreception offer a unique opportunity investigate impacts absence conscious vision, presumably through ipRGCs. Here, we show that three such patients were able choose nonrandomly about presence despite their complete lack sight. Furthermore, 2 sec blue modified EEG activity when administered simultaneously auditory stimulations. fMRI further showed that, during working memory task, less than minute triggered recruitment supplemental prefrontal thalamic regions involved cognition regulation as well key areas default mode network. These results, which have be considered proof concept, triggers some awareness for can more rapid human previously understood, if processing actively engaged. stimulates higher activity, independently engages perform ongoing process. To our knowledge, results constitute first indication ipRGC signaling may rapidly affect fundamental cerebral organization, it could potentially participate numerous aspects function.

Language: Английский

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Benefits and costs of artificial nighttime lighting of the environment

Environmental Reviews, Journal Year: 2014, Volume and Issue: 23(1), P. 14 - 23

Published: July 9, 2014

Artificial lighting has transformed the outdoor nighttime environment over large areas, modifying natural cycles of light in terms timing, wavelength, and distribution. This had widespread benefits costs to humankind, impacting on health wellbeing, vehicle accidents, crime, energy consumption carbon emissions, aesthetics, wildlife ecosystems. Here, we review these effects, particularly context ongoing developments extent artificial prevalent technologies being employed. The key issue that emerges is how best maximize whilst limiting costs. To do so, three main strategies are required. First, important knowledge gaps need be filled. Second, there an urgent connect research conducted different disciplines, which date been very disjointed. Third, it imperative much firmer well-developed links made between research, policy, practice.

Language: Английский

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Light therapy in the treatment of patients with bipolar depression: A meta-analytic study

European Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 26(6), P. 1037 - 1047

Published: March 9, 2016

Language: Английский

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Stress, the cortisol awakening response and cognitive function

International review of neurobiology, Journal Year: 2020, Volume and Issue: unknown, P. 187 - 217

Published: Jan. 1, 2020

Language: Английский

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Day and night light exposure are associated with psychiatric disorders: an objective light study in >85,000 people

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(11), P. 853 - 862

Published: Oct. 9, 2023

Language: Английский

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Light as a Modulator of Non-Image-Forming Brain Functions—Positive and Negative Impacts of Increasing Light Availability

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(1), P. 116 - 140

Published: March 17, 2023

Light use is rising steeply, mainly because of the advent light-emitting diode (LED) devices. LEDs are frequently blue-enriched light sources and may have different impacts on non-image forming (NIF) system, which maximally sensitive to blue-wavelength light. Most importantly, timing LED device widespread, leading novel exposure patterns NIF system. The goal this narrative review discuss multiple aspects that we think should be accounted for when attempting predict how situation will affect impact brain functions. We first cover both image-forming pathways brain. then detail our current understanding human cognition, sleep, alertness, mood. Finally, questions concerning adoption lighting screens, offer new opportunities improve well-being, but also raise concerns about increasing exposure, detrimental health, particularly in evening.

Language: Английский

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