Genomic signatures of evolutionary transitions from solitary to group living

Science, Journal Year: 2015, Volume and Issue: 348(6239), P. 1139 - 1143

Published: May 15, 2015

For bees, many roads lead to social harmony Eusociality, where workers sacrifice their reproductive rights support the colony, has evolved repeatedly and represents most form of evolution in insects. Kapheim et al. looked across genomes 10 bee species with varying degrees sociality determine underlying genomic contributions. No one path led eusociality, but similarities were seen features such as increases gene regulation methylation. It also seems that selection pressures relaxed after emergence complex sociality. Science , this issue p. 1139

Language: Английский

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Interplay between gene expression noise and regulatory network architecture

Trends in Genetics, Journal Year: 2012, Volume and Issue: 28(5), P. 221 - 232

Published: Feb. 25, 2012

Language: Английский

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Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(45), P. 13970 - 13975

Published: Oct. 19, 2015

Significance In eusocial insect societies, such as ants and some bees wasps, phenotypes are highly plastic, generating alternative (queens workers) from the same genome. The greatest plasticity is found in simple which individuals can switch between adults. genomic, transcriptional, epigenetic underpinnings of largely unknown. contrast to complex societies honeybee, we find that lack distinct transcriptional differentiation coherently patterned DNA methylomes. Instead, defined by subtle network organization. These traits may facilitate genomic plasticity. insights resources will stimulate new approaches hypotheses help unravel processes create phenotypic

Language: Английский

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A mutualistic symbiosis between a parasitic mite and a pathogenic virus undermines honey bee immunity and health

Proceedings of the National Academy of Sciences, Journal Year: 2016, Volume and Issue: 113(12), P. 3203 - 3208

Published: March 7, 2016

Significance The parasitic mite Varroa destructor and the deformed wing virus (DWV) are linked in a mutualistic symbiosis. acts as vector of viral pathogen, whereas DWV-induced immunosuppression honey bees favors feeding reproduction. This functional interaction underpins rapidly escalating immunosuppression, which can be primed and/or aggravated by wealth stress factors that co-trigger colony losses. Our experimental results explain pivotal role proposed for –DWV association induction bee Here we provide framework studying dynamics this multifactorial syndrome defining effective strategies to reduce its negative impact on beekeeping industry.

Language: Английский

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Population genomics of the honey bee reveals strong signatures of positive selection on worker traits

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(7), P. 2614 - 2619

Published: Jan. 31, 2014

Significance Most hypotheses explaining the evolution of sociality in insects assume that positive selection drives worker traits. Yet we know little about extent natural acting on social insects. We produced a map for honey bee through analysis 40 individual genomes. found strong evidence genes and regulatory sequences, discovered mutations worker-biased proteins tend to have greater fitness effects than queen-biased proteins. also many instances influence traits, suggesting phenotypes represent major vector adaptation

Language: Английский

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Eusocial insects as emerging models for behavioural epigenetics

Nature Reviews Genetics, Journal Year: 2014, Volume and Issue: 15(10), P. 677 - 688

Published: Sept. 9, 2014

Language: Английский

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Understanding the Relationship Between Brain Gene Expression and Social Behavior: Lessons from the Honey Bee

Annual Review of Genetics, Journal Year: 2012, Volume and Issue: 46(1), P. 591 - 615

Published: Sept. 20, 2012

Behavior is a complex phenotype that plastic and evolutionarily labile. The advent of genomics has revolutionized the field behavioral genetics by providing tools to quantify dynamic nature brain gene expression in relation output. honey bee Apis mellifera provides an excellent platform for investigating relationship between behavior given both remarkable repertoire expressed members its intricate society degree which influenced heredity social environment. Here, we review linked series studies assayed changes transcriptomes associated with natural experimentally induced state. These experiments demonstrate closely behavior, mediate association specific genes exists over multiple timescales, from physiological evolutionary.

Language: Английский

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Neuromolecular responses to social challenge: Common mechanisms across mouse, stickleback fish, and honey bee

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(50), P. 17929 - 17934

Published: Dec. 1, 2014

Significance In some cases similar molecular programs (i.e., conserved genes and gene networks) underlie the expression of phenotypic traits that evolve repeatedly across diverse species. We investigated this possibility in context social behavioral response, using a comparative genomics approach for three distantly related species: house mouse ( Mus musculus ), stickleback fish Gasterosteus aculeatus honey bee Apis mellifera ). An experience territory intrusion modulated brain functional processes species, including hormone-mediated signal transduction, neurodevelopment, chromosome organization, energy metabolism. Several homologous transcription factors also responded consistently to intrusion, suggesting shared neuronal effects may involve transcriptional cascades evolutionarily genes. These results indicate genetic “toolkits” are involved independent evolutions behavior.

Language: Английский

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Genetics of Aggression

Annual Review of Genetics, Journal Year: 2012, Volume and Issue: 46(1), P. 145 - 164

Published: Aug. 30, 2012

Aggression mediates competition for food, mating partners, and habitats and, among social animals, establishes stable dominance hierarchies. In humans, abnormal aggression is a hallmark of neuropsychiatric disorders can be elicited by environmental factors acting on an underlying genetic susceptibility. Identifying the architecture that predisposes to aggressive behavior in people challenging because difficulties quantifying phenotype, heterogeneity, uncontrolled conditions. Studies mice have identified single-gene mutations result hyperaggression, contingent background. These studies complemented systems genetics approaches Drosophila melanogaster, which mutational analyses together with genome-wide transcript analyses, artificial selection studies, analysis epistasis revealed large segment genome contributes manifestation widespread epistatic interactions. Comparative genomic based principle evolutionary conservation are needed enable complete dissection neurogenetic underpinnings this universal fitness trait.

Language: Английский

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Correspondence between Resting-State Activity and Brain Gene Expression

Neuron, Journal Year: 2015, Volume and Issue: 88(4), P. 659 - 666

Published: Nov. 1, 2015

The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent fMRI resting-state datasets to regional cortical a newly generated RNA-seq dataset additional obtain robust reproducible correlations. We find significantly more genes correlated with fALFF than expected chance specific imaging signals multiple default mode network. Together, these data support population-level steady-state activity.

Language: Английский

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