The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems DOI Creative Commons
Meet Zandawala,

Shi Tian,

Maurice R. Elphick

et al.

General and Comparative Endocrinology, Journal Year: 2017, Volume and Issue: 264, P. 64 - 77

Published: June 14, 2017

Gonadotropin-releasing hormone (GnRH) was first discovered in mammals on account of its effect triggering pituitary release gonadotropins and the importance this discovery recognized forty years ago award 1977 Nobel Prize for Physiology or Medicine. Investigation evolution GnRH revealed that GnRH-type signaling systems occur throughout chordates, including agnathans (e.g. lampreys) urochordates sea squirts). Furthermore, adipokinetic (AKH) is ligand a receptor arthropod Drosophila melanogaster provided evidence antiquity signaling. However, occurrence other AKH-like peptides arthropods, which include corazonin AKH/corazonin-related peptide (ACP), has complicated efforts to reconstruct evolutionary history family related neuropeptides. Genome/transcriptome sequencing both receptors corazonin-type lophotrochozoan protostomes (annelids, mollusks) deuterostomian invertebrates (cephalochordates, hemichordates, echinoderms). act as ligands have been identified mollusks. what lacking experimental distinct peptide-receptor pathways deuterostomes. Importantly, we recently reported identification two neuropeptides either an echinoderm species – common European starfish Asterias rubens. Discovery invertebrate demonstrated time evolutionarily origin these paralogous can be traced ancestor lineage-specific losses (in vertebrates, nematodes) duplication system arthropods (giving rise AKH ACP systems) quadruplication vertebrates (followed by duplications) accounts phylogenetic distribution GnRH/corazonin-type extant animals. Informed new insights, here review research neuropeptide propose standardized nomenclature wherein are named “GnRH” “corazonin”, with exception arisen gene lineage referred “AKH” (or red pigment concentrating hormone, “RCPH”, crustaceans) “ACP”.

Language: Английский

Molecular topography of an entire nervous system DOI Creative Commons
Seth R. Taylor, Gabriel Santpere, Alexis Weinreb

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4329 - 4347.e23

Published: July 7, 2021

Language: Английский

Citations

551
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior DOI
Dick R. Nässel, Meet Zandawala

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

Citations

307
From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system DOI
Detlev Arendt, Maria Antonietta Tosches, Heather Marlow

et al.

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 17(1), P. 61 - 72

Published: Dec. 17, 2015

Language: Английский

Citations

261
Evolution of neuropeptide signalling systems DOI Creative Commons
Maurice R. Elphick, Olivier Mirabeau, Dan Larhammar

et al.

Journal of Experimental Biology, Journal Year: 2018, Volume and Issue: 221(3)

Published: Feb. 1, 2018

ABSTRACT Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships evolutionary origins heterogeneous assemblage neuropeptides identified range phyla has presented huge challenge for comparative physiologists. Here, we review revolutionary insights into evolution neuropeptide have been obtained recently through analysis genome/transcriptome sequence data by ‘deorphanisation’ receptors. The at least 30 systems traced to common ancestor protostomes deuterostomes. Furthermore, two rounds genome duplication gave rise an expanded repertoire vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss additional or duplications generating complex patterns phylogenetic distribution paralogous systems. We entering new era research where it become feasible compare roles orthologous wide phyla. Moreover, ambitious mission reconstruct function animal kingdom now represents tangible future.

Language: Английский

Citations

250
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors DOI Creative Commons
Simon R. Foster, Alexander S. Hauser,

Line Vedel

et al.

Cell, Journal Year: 2019, Volume and Issue: 179(4), P. 895 - 908.e21

Published: Oct. 1, 2019

The peptidergic system is the most abundant network of ligand-receptor-mediated signaling in humans. However, physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). Here we report pairing cognate receptors. Integrating comparative genomics across 313 species bioinformatics on all protein sequences structures human class A GPCRs, identify universal characteristics that uncover additional potential systems. Using three orthogonal biochemical assays, pair 17 proposed endogenous ligands with five orphan GPCRs are associated diseases, including genetic, neoplastic, nervous reproductive disorders. We also nine recognized pathophysiological roles. This integrated computational multifaceted experimental approach expands peptide-GPCR opens way studies to elucidate these systems physiology disease.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJjMTgxN2U1NzM3NDczNDM2ODEzNzEyODI5NjI5ODYzNSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4OTY2ODg4fQ.Mw-9M-TkUK_8BM9HEx5liKVc3qqMRZAYnnoj_HmgWhIhhmpp19D5OQJn7R1yFhp35_YaKS4WTzgov3sM7XhWijlW2iJT5DseWco-3ZSibIksewyRrYFJfG-i1C8Ti0zXxzwV7YB7oqR4EUUR2SXkkCCGVOxninjXA5mqvhPrd85F4QSFypQtlIpN4n0wZzxuYg1wycpmB6Sb0VvAQvmHKNASaM9uBmn0ww5zPexIIuzRNI915OD2AvmWnNgLlJwxg9ceLm7H62FW5HfIFtxAk6f5Eb9qi3OXathS3qL2VRY5z5fyz9KketH65_DMaJSZcwaziw2wwR_nC8MUlLy7AQ(mp4, (34.57 MB) Download video

Language: Английский

Citations

223
Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila DOI Creative Commons
Michael Kunst, Michael E. Hughes, Davide Raccuglia

et al.

Current Biology, Journal Year: 2014, Volume and Issue: 24(22), P. 2652 - 2664

Published: Oct. 30, 2014

Language: Английский

Citations

200
System-wide mapping of peptide-GPCR interactions in C. elegans DOI Creative Commons
Isabel Beets,

Sven Zels,

Elke Vandewyer

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113058 - 113058

Published: Aug. 31, 2023

Neuropeptides and peptide hormones are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs). However, the organization of peptidergic network roles many peptides remain elusive, as our insight into peptide-receptor interactions is limited GPCRs still orphan receptors. Here we report genome-wide peptide-GPCR interaction map in Caenorhabditis elegans. By reverse pharmacology screening over 55,384 possible interactions, identify 461 cognate couples uncover with specific complex combinatorial encoded across within single genes. These provide insights functions evolution. Combining dataset phylogenetic analysis supports co-evolution conservation at least 14 bilaterian systems C. This resource lays foundation for system-wide network.

Language: Английский

Citations

76
Synaptic transmission parallels neuromodulation in a central food-intake circuit DOI Creative Commons
Philipp Schlegel, Michael J. Texada, Anton Miroschnikow

et al.

eLife, Journal Year: 2016, Volume and Issue: 5

Published: Nov. 15, 2016

NeuromedinU is a potent regulator of food intake and activity in mammals. In Drosophila , neurons producing the homologous neuropeptide hugin regulate feeding locomotion similar manner. Here, we use EM-based reconstruction to generate entire connectome hugin-producing larval CNS. We demonstrate that synaptic transmission addition peptidergic neuromodulation identify acetylcholine as key transmitter. Hugin are both necessary for regulatory effect on feeding. further show subtypes connect chemosensory endocrine system by combinations peptide-receptor connections. Targets include DH44, CRH-like peptide, insulin-like peptides. Homologs these peptides likewise downstream neuromedinU, revealing striking parallels flies propose part an ancient physiological control has been conserved at functional molecular level.

Language: Английский

Citations

145
The neuropeptide complement of the marine annelid Platynereis dumerilii DOI Creative Commons

Markus Conzelmann,

Elizabeth A. Williams, Karsten Krug

et al.

BMC Genomics, Journal Year: 2013, Volume and Issue: 14(1), P. 906 - 906

Published: Jan. 1, 2013

The marine annelid Platynereis dumerilii is emerging as a powerful lophotrochozoan experimental model for evolutionary developmental biology (evo-devo) and neurobiology. Recent studies revealed the presence of conserved neuropeptidergic signaling in Platynereis, including vasotocin/neurophysin, myoinhibitory peptide opioid peptidergic systems. Despite these advances, comprehensive peptidome resources have yet to be reported.The present work describes neuropeptidome Platynereis. We established large transcriptome resource, consisting stage-specific next-generation sequencing datasets 77,419 expressed sequence tags. Using this information combination bioinformatic searches mass spectrometry analyses, we increased known proneuropeptide (pNP) complement 98. Based on homology metazoan pNPs, pNPs were grouped into ancient eumetazoan, bilaterian, protostome, lophotrochozoan, families, only found Compared planarian Schmidtea mediterranea, other with large-scale pNP has remarkably full 53 belonging eumetazoan or bilaterian families. Our search strategy, combined analyses conservation, also allowed us define several novel map changes expression throughout life cycle.The repertoire highlights usefulness annelids comparative neuroendocrinology. This establishes reference dataset peptidomics lophotrochozoans provides basis future signaling.

Language: Английский

Citations

144
Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution DOI Creative Commons
Dean C. Semmens, Olivier Mirabeau, Ismail Moghul

et al.

Open Biology, Journal Year: 2016, Volume and Issue: 6(2), P. 150224 - 150224

Published: Feb. 1, 2016

Neuropeptides are evolutionarily ancient mediators of neuronal signalling in nervous systems. With recent advances genomics/transcriptomics, an increasingly wide range species has become accessible for molecular analysis. The deuterostomian invertebrates particular interest this regard because they occupy ‘intermediate' position animal phylogeny, bridging the gap between well-studied model protostomian (e.g. Drosophila melanogaster , Caenorhabditis elegans ) and vertebrates. Here we have identified 40 neuropeptide precursors starfish Asterias rubens a invertebrate from phylum Echinodermata . Importantly, these include kisspeptin-type melanin-concentrating hormone-type precursors, which first to be discovered non-chordate species. Starfish tachykinin-type, somatostatin-type, pigment-dispersing factor-type corticotropin-releasing echinoderm/ambulacrarian clade kingdom. Other vasopressin/oxytocin-type, gonadotropin-releasing hormone-type, thyrotropin-releasing calcitonin-type, cholecystokinin/gastrin-type, orexin-type, luqin-type, pedal peptide/orcokinin-type, glycoprotein bursicon-type, relaxin-type insulin-like growth precursors. This is most comprehensive identification precursor proteins echinoderm date, yielding new insights into evolution Furthermore, data provide basis experimental analysis function unique context decentralized, pentaradial bauplan.

Language: Английский

Citations

141