International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(20), P. 7660 - 7660
Published: Oct. 16, 2020
Alzheimer’s
disease
(AD)
is
an
irreversible,
age-related
progressive
neurological
disorder,
and
the
most
common
type
of
dementia
in
aged
people.
Neuropathological
lesions
AD
are
neurofibrillary
tangles
(NFTs),
senile
plaques
comprise
accumulated
amyloid-beta
(Aβ),
loaded
with
metal
ions
including
Cu,
Fe,
or
Zn.
Some
reports
have
identified
dyshomeostasis
as
a
neurotoxic
factor
AD,
among
which
Cu
seem
to
be
central
cationic
formation
plaque
soluble
oligomers,
essential
role
pathology.
Cu-Aβ
complex
catalyzes
generation
reactive
oxygen
species
(ROS)
results
oxidative
damage.
Several
studies
indicated
that
stress
plays
crucial
pathogenesis
AD.
The
connection
copper
levels
still
ambiguous,
some
researches
indicate
deficiency,
while
others
show
its
higher
content
therefore
there
need
increase
decrease
animal
models,
respectively,
study
one
cause.
For
more
than
twenty
years,
many
vitro
been
devoted
identifying
metals’
roles
Aβ
accumulation,
damage,
neurotoxicity.
Towards
end,
short
review
modern
therapeutic
approach
chelation
therapy,
main
focus
on
ions,
discussed.
Despite
lack
strong
proofs
clinical
advantage
so
far,
conjecture
using
chelator
effective
strategy
for
remains
popular.
However,
recent
genetic-regulating
transporters
models
shed
light
treating
this
refractory
disease.
This
aims
succinctly
present
better
understanding
ions’
current
status
several
features,
conflicting
herein.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(4), P. 2545 - 2647
Published: Feb. 5, 2021
Protein
misfolding
and
aggregation
is
observed
in
many
amyloidogenic
diseases
affecting
either
the
central
nervous
system
or
a
variety
of
peripheral
tissues.
Structural
dynamic
characterization
all
species
along
pathways
from
monomers
to
fibrils
challenging
by
experimental
computational
means
because
they
involve
intrinsically
disordered
proteins
most
diseases.
Yet
understanding
how
amyloid
become
toxic
challenge
developing
treatment
for
these
Here
we
review
what
computer,
vitro,
vivo,
pharmacological
experiments
tell
us
about
accumulation
deposition
oligomers
(Aβ,
tau),
α-synuclein,
IAPP,
superoxide
dismutase
1
proteins,
which
have
been
mainstream
concept
underlying
Alzheimer's
disease
(AD),
Parkinson's
(PD),
type
II
diabetes
(T2D),
amyotrophic
lateral
sclerosis
(ALS)
research,
respectively,
years.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(2), P. 1221 - 1322
Published: Aug. 10, 2018
Neurodegenerative
diseases
pose
a
substantial
socioeconomic
burden
on
society.
Unfortunately,
the
aging
world
population
and
lack
of
effective
cures
foreshadow
negative
outlook.
Although
large
amount
research
has
been
dedicated
to
elucidating
pathologies
neurodegenerative
diseases,
their
principal
causes
remain
elusive.
Metal
ion
dyshomeostasis,
proteopathy,
oxidative
stress,
neurotransmitter
deficiencies
are
pathological
features
shared
across
multiple
disorders.
In
addition,
these
factors
proposed
be
interrelated
upon
disease
progression.
Thus,
development
multifunctional
compounds
capable
simultaneously
interacting
with
several
components
suggested
as
solution
undertake
complex
diseases.
this
review,
we
outline
discuss
possible
therapeutic
targets
in
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis
molecules,
previously
designed
or
discovered
potential
drug
candidates
for
disorders
emphasis
multifunctionality.
underrepresented
areas
discussed
indicate
new
directions.
Chemical Society Reviews,
Journal Year:
2016,
Volume and Issue:
46(2), P. 310 - 323
Published: Nov. 23, 2016
This
review
illustrates
the
recent
understanding
of
amyloid-β
oligomers'
characteristics
and
toxicity-related
pathways,
along
with
inhibitors
against
Aβ
aggregation.
Journal of Agricultural and Food Chemistry,
Journal Year:
2019,
Volume and Issue:
67(4), P. 1029 - 1043
Published: Jan. 17, 2019
Tea,
leaf,
or
bud
from
the
plant
Camellia
sinensis,
make
up
some
of
beverages
popularly
consumed
in
different
parts
world
as
green
tea,
oolong
black
tea.
More
particularly,
a
nonfermented
tea
has
gained
more
renown
because
significant
health
benefits
assigned
to
its
rich
content
polyphenols.
As
main
constituent,
polyphenols
were
documented
for
their
antioxidant,
anti-inflammation,
anticancer,
anticardiovascular,
antimicrobial,
antihyperglycemic,
and
antiobesity
properties.
Recent
reports
demonstrate
that
may
exert
positive
effect
on
reduction
medical
chronic
conditions
such
cardiovascular
disease,
cancer,
Alzheimer's
Parkinson's
diabetes.
The
teas,
particular
EGCG,
are
widely
investigated,
these
effects
known
be
primarily
associated
with
structure
compositions
This
Review
focuses
diverse
constituents
molecular
mechanisms
perspective
potential
therapeutic
function.
advances
bioavailability,
bioaccessibility,
microbiota
also
summarized
this
article.
Dietary
supplementation
represents
an
attractive
alternative
toward
promoting
human
health.
Nutrients,
Journal Year:
2015,
Volume and Issue:
7(7), P. 5443 - 5468
Published: July 7, 2015
Obesity
and
being
overweight
are
linked
with
a
cluster
of
metabolic
vascular
disorders
that
have
been
termed
the
syndrome.
This
syndrome
promotes
incidence
cardiovascular
diseases
an
important
public
health
problem
because
they
represent
major
cause
death
worldwide.
Whereas
there
is
not
universally-accepted
set
diagnostic
criteria,
most
expert
groups
agree
this
defined
by
endothelial
dysfunction,
impaired
insulin
sensitivity
hyperglycemia,
dyslipidemia,
abdominal
obesity
hypertension.
Epidemiological
studies
suggest
beneficial
effects
diets
rich
in
green
tea
are,
part,
mediated
their
flavonoid
content,
particular
benefits
provided
members
family
such
as
epigallocatechin
gallate
(EGCG).
Although
bioavailability
discussed,
various
EGCG
modulates
cellular
molecular
mechanisms
symptoms
leading
to
Therefore,
according
vitro
vivo
model
data,
review
attempts
increase
our
understanding
about
properties
prevent
