FEMS Microbiology Reviews, Journal Year: 2015, Volume and Issue: 39(4), P. 567 - 591

Published: May 3, 2015

Blood in healthy organisms is seen as a 'sterile' environment: it lacks proliferating microbes. Dormant or not-immediately-culturable forms are not absent, however, intracellular dormancy well established. We highlight here that great many pathogens can survive blood and inside erythrocytes. 'Non-culturability', reflected by discrepancies between plate counts total counts, commonplace environmental microbiology. It overcome improved culturing methods, we asked how common this would be blood. A number of recent, sequence-based ultramicroscopic studies have uncovered an authentic microbiome non-communicable diseases. The chief origin these microbes the gut (especially when shifts composition to pathogenic state, known 'dysbiosis'). Another source translocated from oral cavity. 'Dysbiosis' also used describe translocation cells into other tissues. To avoid ambiguity, use term 'atopobiosis' for appear places than their normal location. Atopobiosis may contribute dynamics variety inflammatory Overall, seems more chronic, non-communicable, diseases microbial component presently considered, treatable using bactericidal antibiotics vaccines.

Language: Английский