Molecular mechanisms and physiological importance of circadian rhythms

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 21(2), P. 67 - 84

Published: Nov. 25, 2019

Language: Английский

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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment

Trends in cancer, Journal Year: 2019, Volume and Issue: 5(8), P. 475 - 494

Published: Aug. 1, 2019

Language: Английский

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Circadian clock genes and the transcriptional architecture of the clock mechanism

Journal of Molecular Endocrinology, Journal Year: 2019, Volume and Issue: 63(4), P. R93 - R102

Published: Sept. 26, 2019

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with of organism (such eating and sleeping) helps different tissue organ systems coordinate optimize their performance. full extent mechanisms by which cells maintain are still under investigation, but involve a core set genes that regulate large networks gene transcription both direct transcriptional activation/repression well recruitment proteins modify chromatin states more broadly.

Language: Английский

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Sleep and the athlete: narrative review and 2021 expert consensus recommendations

British Journal of Sports Medicine, Journal Year: 2020, Volume and Issue: 55(7), P. 356 - 368

Published: Nov. 3, 2020

Elite athletes are particularly susceptible to sleep inadequacies, characterised by habitual short (<7 hours/night) and poor quality (eg, fragmentation). Athletic performance is reduced a night or more without sleep, but the influence on of partial restriction over 1–3 nights, real-world scenario, remains unclear. Studies investigating in often suffer from inadequate experimental control, lack females questions concerning validity chosen assessment tools. Research only scratches surface how influences athlete health. wider population show that habitually sleeping <7 hours/night increases susceptibility respiratory infection. Fortunately, much known about salient risk factors for inadequacy athletes, enabling targeted interventions. For example, influenced sport-specific (relating training, travel competition) non-sport female gender, stress anxiety). This expert consensus culminates with toolbox practitioners covering education screening) mitigate these optimise sleep. A one-size-fits-all approach recommendations 7–9 unlikely ideal health performance. We recommend an individualised should consider athlete’s perceived needs. needed into benefits napping extension banking sleep).

Language: Английский

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Immune cell regulation of glia during CNS injury and disease

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 139 - 152

Published: Feb. 10, 2020

Language: Английский

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Medicine in the Fourth Dimension

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(2), P. 238 - 250

Published: Aug. 1, 2019

Language: Английский

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Cell-autonomous clock of astrocytes drives circadian behavior in mammals

Science, Journal Year: 2019, Volume and Issue: 363(6423), P. 187 - 192

Published: Jan. 11, 2019

Circadian (~24-hour) rhythms depend on intracellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular integration and thereby direct daily of behavior in animals is largely obscure. The suprachiasmatic nucleus (SCN) the fulcrum this pathway from gene to cell circuit mammals. We describe type-specific, functionally distinct TTFLs neurons astrocytes SCN show that, absence other clocks, cell-autonomous astrocytic TTFL alone can drive molecular oscillations circadian mice. Astrocytic by reinstating clock expression function via glutamatergic signals. Our results demonstrate that autonomously initiate sustain complex mammalian behavior.

Language: Английский

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Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(3), P. 456 - 467

Published: Feb. 17, 2020

Language: Английский

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Communicating clocks shape circadian homeostasis

Science, Journal Year: 2021, Volume and Issue: 371(6530)

Published: Feb. 11, 2021

Regulating multiple body clocks Circadian rhythms that affect tissues and organ systems are aligned with the dark-light cycle other external inputs such as feeding. But how is time keeping modulated throughout complex anatomical regions? Koronowski Sassone-Corsi reviewed central regulators in brain peripheral organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of rhythm modulation important understand behavior disease, because dysregulated associated metabolic syndrome cancer. Science , this issue p. eabd0951

Language: Английский

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Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 92 - 110.e4

Published: April 18, 2019

Language: Английский

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