Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption

Life Sciences, Journal Year: 2017, Volume and Issue: 173, P. 94 - 106

Published: Feb. 16, 2017

Language: Английский

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Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

Endocrine Reviews, Journal Year: 2016, Volume and Issue: 37(6), P. 584 - 608

Published: Oct. 20, 2016

Abstract Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior physiology in humans. Relatively recent changes to our environments, such as the introduction artificial lighting, can disorganize circadian system, from level molecular clocks that regulate cellular activities synchronization between daily cycles solar day. Sleep/wake are intertwined with global trends indicate these, too, increasingly subject disruption. A large proportion world's population is at increased risk environmentally driven rhythm sleep disruption, a minority individuals also genetically predisposed misalignment disorders. The consequences disruption system profound include myriad metabolic ramifications, some which may be compounded by adverse effects on dietary choices. If not addressed, deleterious will continue cause widespread health problems; therefore, implementation numerous behavioral pharmaceutical interventions help restore alignment enhance important.

Language: Английский

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Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies

Journal of the American Heart Association, Journal Year: 2017, Volume and Issue: 6(9)

Published: Sept. 10, 2017

Background Effects of extreme sleep duration on risk mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose‐response relationships with all‐cause mortality, total disease, coronary heart stroke. Methods Results PubMed Embase were systematically searched for prospective cohort studies published before December 1, 2016, that examined associations between at least 1 4 in generally healthy populations. U‐shaped indicated all outcomes, lowest observed ≈7‐hour per day, which was varied little by sex. For when <7 hours pooled relative (RR) 1.06 (95% CI , 1.04–1.07) 1‐hour reduction; >7 RR 1.13 1.11–1.15) increment. 1.03–1.08) reduction 1.12 1.08–1.16) increment duration. 1.07 1.03–1.12) 1.05 1.00–1.10) stroke, 1.01–1.09) 1.18 1.14–1.21) Conclusions Our findings indicate both short long is associated an increased events.

Language: Английский

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Association between circadian rhythms and neurodegenerative diseases

The Lancet Neurology, Journal Year: 2019, Volume and Issue: 18(3), P. 307 - 318

Published: Feb. 12, 2019

Language: Английский

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Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1234 - 1234

Published: May 30, 2019

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects

Language: Английский

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Environmental Determinants of Cardiovascular Disease

Circulation Research, Journal Year: 2017, Volume and Issue: 121(2), P. 162 - 180

Published: July 6, 2017

Many features of the environment have been found to exert an important influence on cardiovascular disease (CVD) risk, progression, and severity. Changes in because migration different geographic locations, modifications lifestyle choices, shifts social policies cultural practices alter CVD even absence genetic changes. Nevertheless, cumulative impact risk has difficult assess mechanisms by which some factors remain obscure. Human environments are complex, their natural, social, personal domains highly variable diversity human ecosystems, evolutionary histories, structures, individual choices. Accumulating evidence supports notion that ecological such as diurnal cycles light day, sunlight exposure, seasons, characteristics natural altitude, latitude, greenspaces determinants health risk. In developed societies, is moderated physical built pollution, well socioeconomic status networks. These attributes shape choices significantly modify An understanding how environment, individually collectively, affect could lead a better appraisal aid development new preventive therapeutic strategies limit increasingly high global burden heart stroke.

Language: Английский

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The aging clock: circadian rhythms and later life

Journal of Clinical Investigation, Journal Year: 2017, Volume and Issue: 127(2), P. 437 - 446

Published: Jan. 31, 2017

Circadian rhythms play an influential role in nearly all aspects of physiology and behavior the vast majority species on Earth. The biological clockwork that regulates these is dynamic over lifespan: rhythmic activities such as sleep/wake patterns change markedly we age, many cases they become increasingly fragmented. Given prolonged disruptions normal are highly detrimental to health, deeper knowledge how our clocks with age may create valuable opportunities improve health longevity for aging global population. In this Review, synthesize key findings from study circadian later life, identify documented date, review potential physiological mechanisms underlie changes.

Language: Английский

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Bile Acid Metabolism in Liver Pathobiology

Gene Expression, Journal Year: 2018, Volume and Issue: 18(2), P. 71 - 87

Published: Jan. 12, 2018

Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver other tissues cells from toxicity. metabolism tightly regulated by synthesis in the biotransformation intestine. are endogenous ligands that activate a complex network of nuclear receptor farnesoid X membrane G protein-coupled receptor-1 regulate hepatic lipid glucose metabolic homeostasis energy metabolism. The gut-to-liver axis plays critical role regulation enterohepatic circulation acids, pool size, composition. control gut bacteria overgrowth, metabolize host Alteration high-fat diets, sleep disruption, alcohol, drugs reshapes microbiome causes dysbiosis, obesity, disorders. Gender differences metabolism, FXR signaling, microbiota have been linked higher prevalence fatty disease hepatocellular carcinoma males. contributes cholestatic diseases, inflammatory diseases digestive system, diabetes. acid-activated receptors potential therapeutic targets developing treat

Language: Английский

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Role of the circadian system in cardiovascular disease

Journal of Clinical Investigation, Journal Year: 2018, Volume and Issue: 128(6), P. 2157 - 2167

Published: May 31, 2018

All species organize behaviors to optimally match daily changes in the environment, leading pronounced activity/rest cycles that track light/dark cycle. Endogenous, approximately 24-hour circadian rhythms brain, autonomic nervous system, heart, and vasculature prepare cardiovascular system for optimal function during these anticipated behavioral cycles. Cardiovascular rhythms, however, may be a double-edged sword. The normal amplified responses morning aid transition from sleep activity, but such exaggerated are potentially perilous individuals susceptible adverse events. Indeed, occurrence of stroke, myocardial infarction, sudden cardiac death all have patterns, striking most frequently morning. Furthermore, chronic disruptions clock, as with night-shift work, contribute increased risk. Here we highlight importance disease, identify opportunities optimizing timing medications disease.

Language: Английский

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Later circadian timing of food intake is associated with increased body fat

American Journal of Clinical Nutrition, Journal Year: 2017, Volume and Issue: 106(5), P. 1213 - 1219

Published: Sept. 7, 2017

Language: Английский

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